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Molecules, Vol. 27, Pages 3099: The Signaling Pathways and Targets of Natural Compounds from Traditional Chinese Medicine in Treating Ischemic Stroke
This study aims to update and summarize the signaling pathways and targets of natural compounds in the treatment of IS, and provide a base of information for the future development of effective treatments for IS.
Source: Molecules - May 12, 2022 Category: Chemistry Authors: Xing-Hua Li Feng-Ting Yin Xiao-Hang Zhou Ai-Hua Zhang Hui Sun Guang-Li Yan Xi-Jun Wang Tags: Review Source Type: research
Mechanism of < em > Salvia miltiorrhiza Bge < /em > . for the Treatment of Ischemic Stroke Based on Bioinformatics and Network Pharmacology
In this study, SymMap was used to screen the 50 bioactive scored components and 65 putative targets of Salvia miltiorrhiza Bge., and their targets were standardized using the UniProt platform. The disease targets related to stroke were collected by comparative toxicogenomics database (CTD), GeneCards, and quantitative structure-activity relationships-TargetNet (QSAR-TargetNet). Thereafter, the protein-protein interaction (PPI) network was constructed using the STRING platform and visualized by Cytoscape (3.8.2) software. Then, the Metascape platform was used to analyze the Gene Ontology (GO) enrichment analysis and Kyoto E...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2022 Category: Complementary Medicine Authors: Jiaqi Wu Ming Li Ang Li Xunming Ji Source Type: research
Effect of tonifying liver and kidney-essence herbs on expression of Nogo-A and p75(NTR) in cerebral ischemic stroke rats model.
CONCLUSION: Suppressing the expression of Nogo-A and p75(NTR) is possibly one of the mechanisms underlying the ability of tonifying liver and kidney-essence herbs to promote recovery of the injured central nervous system.
PMID: 23427407 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - December 1, 2012 Category: Complementary Medicine Authors: Yan Y, Li T, Liu L, Zhou H Tags: J Tradit Chin Med Source Type: research
An Analysis of the Combination Frequencies of Constituent Medicinal Herbs in Prescriptions for the Treatment of Stroke in Korean Medicine: Determination of a Group of Candidate Prescriptions for Universal Use.
Authors: Yun BC, Pae SB, Han YK, Choi MJ, Choi BT, Shin HK, Baek JU
Abstract
In contrast to Western medicine, which typically prescribes one medicine to treat a specific disease, traditional East Asian medicine uses any one of a large number of different prescriptions (mixtures of medicinal herbs), according to the patient's characteristics. Although this can be considered an advantage, the lack of a universal prescription for a specific disease is considered a drawback of traditional East Asian medicine. The establishment of universally applicable prescriptions for specific diseases is therefore required. As a bas...
Source: Evidence-based Complementary and Alternative Medicine - April 20, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice
Conclusions: These results demonstrate therapeutic properties of MLC901, in addition to those previously described, in stimulating revascularization, neuroprotection and repair of the neurovascular unit after ischemic stroke.Cerebrovasc Dis 2016;42:139-154
Source: Cerebrovascular Diseases - April 21, 2016 Category: Neurology Source Type: research
Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury
AbstractNeuronal apoptotic cell death plays an important role in many neurological disorders, including Alzheimer ’s disease, Parkinson’s disease, and ischemic stroke. Spatholobi Caulis (SC) has been widely used in traditional herbal medicine for the treatment of cancer, inflammation, viral infection, and anemia. However, the protective effects of SC extract (SCE) against apoptotic cell death in the brain h ave not been reported. We investigated the protective effects of SCE against neuronal injury etoposide-induced neurotoxicity and in rats subjected to focal transient ischemic stroke middle cerebral artery occlusion ...
Source: Molecular Neurobiology - July 13, 2017 Category: Neurology Source Type: research
Gingko biloba may boost memory after stroke, study shows
Herbal extract may protect against nerve cell death Related items fromOnMedica Scan suspected stroke patients within 1 hour, says RCP Blood-thinning drugs appear to protect against dementia in AF patients Big improvements in stroke care Rising use of antithrombotics linked to subdural haematoma RCGP defends ‘under-prescription’ of stroke medicines by GPs
Source: OnMedica Latest News - December 19, 2017 Category: UK Health Source Type: news
Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke
Conclusion Our study firstly demonstrates that SSS extraction is an angiogenic switch. Due to suppressed VEGFR2/Notch1 cascades and activated AKT/mTOR and ERK1/2 signals in BMECs, a feedback loop of angiogenic homeostasis is established. Furthermore, the comprehensive mediations of SDF-1α/CXCR4 axis, AKT/mTOR/HIF-α, ERK1/2 and Notch1 pathways in penumbra contribute to the improvements of neurological function, survival rate and infarct volume post-stroke. Graphical abstract
Source: Phytomedicine - April 10, 2018 Category: Drugs & Pharmacology Source Type: research
Adjunctive herbal medicine treatment for patients with acute ischemic stroke: A systematic review and meta-analysis.
CONCLUSION: The treatment can induce neurological improvements without side effects. However, concrete conclusions cannot be made due to the methodological problems of the included studies.
PMID: 30396610 [PubMed - in process]
Source: Complementary Therapies in Clinical Practice - November 1, 2018 Category: Complementary Medicine Authors: Han CH, Kim M, Cho SY, Jung WS, Moon SK, Park JM, Ko CN, Cho KH, Kwon S Tags: Complement Ther Clin Pract Source Type: research
Neuroprotective effect of Sanqi Tongshuan Tablets on sequelae post-stroke in rats
Conclusion: SQTS showed therapeutic benefits on sequelae post-stroke in rats, which might be through the pathway of regeneration or neuroplasticity.
Source: Chinese Herbal Medicines - December 7, 2018 Category: Complementary Medicine Source Type: research
Effectiveness and safety of Injinoryung-San-Gagambang (Yinchen Wuling powder) decoction on stroke patients with elevated serum liver enzymes: Three case reports
We present 3 cases of hepatic dysfunction caused by polypharmacy, one of which was a 51-year-old man with cerebellum infarction and pneumonia as a complication of stroke. He took multiple medications because of baseline diseases. After recurrence of pneumonia, his laboratory tests showed abnormal aminotransferase levels. Another patient was an 81-year-old woman with cerebral infarction at the right-middle cerebral artery. She was also taking>5 medications. Her laboratory tests conducted on admission showed abnormally elevated aminotransferase levels. The last patient was 77-year-old man with cerebral infarction at the left...
Source: Medicine - December 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network
The objective of this review is to provide comprehensive insight on the effects of Chinese herbal medicines on angiogenesis by regulating HIF-1 pathways in both cancer and ischemic stroke.
Source: Frontiers in Pharmacology - June 25, 2019 Category: Drugs & Pharmacology Source Type: research
Buyang Huanwu Tang (Boyang Hwano Tang) for the treatment of post-stroke fatigue: Protocol for a systematic review of randomized controlled trials
Conclusion:
The conclusion of our systematic review will provide evidence to judge whether BHT is an effective intervention for patients with PSF.
Ethics and dissemination:
Ethical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print.
Trial registration number:
PROSPERO CRD42019130178.
Source: Medicine - September 1, 2019 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Neuroprotective Effect of Daidzein Extracted From Pueraria lobate Radix in a Stroke Model Via the Akt/mTOR/BDNF Channel
Daidzein is a plant isoflavonoid primarily isolated from Pueraria lobate Radix as the dry root of P. lobata (Wild.) Ohwi, have long been used as nutraceutical and medicinal herb in China. Despite the report that daidzein can prevent neuronal damage and improve outcome in experimental stroke, the mechanisms of this neuroprotective action have been not fully elucidated. The aim of this study was to determine whether the daidzein elicits beneficial actions in a stroke model, namely, cerebral ischemia/reperfusion (I/R) injury, and to reveal the underlying neuroprotective mechanisms associated with the regulation of Akt/mTOR/BD...
Source: Frontiers in Pharmacology - January 14, 2022 Category: Drugs & Pharmacology Source Type: research
IJERPH, Vol. 19, Pages 1754: Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Lim
Post-stroke insomnia (PSI) is a highly prevalent complication after stroke. Current evidence of psychotropic drug use for PSI management is scarce and indicates harmful adverse events (AEs). Traditional East Asian herbal medicine is a widely used traditional remedy for insomnia. However, so far, no study has systematically reviewed the efficacy and safety of traditional east asian herbal medicine (HM) for PSI. Therefore, we perform meta-analysis to evaluate the effectiveness and safety of HM for PSI. After a comprehensive electronic search of 15 databases, we review the randomized controlled trials (RCTs) of HM use...
Source: International Journal of Environmental Research and Public Health - February 3, 2022 Category: Environmental Health Authors: Sang-Ho Kim Jung-Hwa Lim Tags: Systematic Review Source Type: research
