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Janssen to Present the Strength and Promise of its Hematologic Malignancies Portfolio and Pipeline at ASH 2021
RARITAN, N.J., November 4, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than 45 company-sponsored abstracts, including 11 oral presentations, plus more than 35 investigator-initiated studies will be featured at the American Society of Hematology (ASH) Annual Meeting and Exposition. ASH is taking place at the Georgia World Congress Center in Atlanta and virtually from December 11-14, 2021.“We are committed to advancing the science and treatment of hematologic malignancies and look forward to presenting the latest research from our robust portfolio and pipeline during ASH...
Source: Johnson and Johnson - November 5, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Review of Plants and Their Constituents in the Therapy of Cerebral Ischemia
Cerebral ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. This leads to cerebral hypoxia and thus to the death of neuronal cells or stroke. The limited number of medicines currently available for patients following ischemic stroke and insufficient data on efficiency of these chemicals in the treatment of stroke led us to the search for novel therapeutic approaches. Recent studies have focused on the possible capacity of natural compounds extracted from vegetables and fruits, to prevent human disabilities caused by cerebral ischemia. In this review, we will discuss som...
Source: Phytotherapy Research - June 11, 2014 Category: Biochemistry Authors: Effat Behravan, Bibi Marjan Razavi, Hossein Hosseinzadeh Tags: Review Source Type: research

Cornel iridoid glycoside reduces infarct size measured by magnetic resonance imaging and improves neurological function after focal cerebral ischemia in rats
Conclusion CIG treatment, starting from 6 h after MCAO, reduced infarct size in the brain as measured by MRI and improved neurological function 2–28 days after focal cerebral ischemia in rats, suggesting that CIG could be a clinical application in improving stroke treatment.
Source: Chinese Journal of Integrative Medicine - August 11, 2015 Category: Internal Medicine Source Type: research

Americans Are Still Eating Too Much Salt
According to a new report from the Centers for Disease Control and Prevention (CDC), Americans are still eating too much salt. The CDC says that 9 in 10 Americans, or 90 percent, consume more sodium than the recommended amount. In the Western diet, most of the sodium we consume comes from the salt. This news is alarming because as everyone should know by now, too much salt in our diets raises our risk for heart disease and leads to potentially life-threatening conditions including high blood pressure, heart attack and stroke. The report says that more than 90 percent of children and 89 percent of adults in the United State...
Source: Healthy Living - The Huffington Post - January 12, 2016 Category: Consumer Health News Source Type: news

Study on cerebroprotective actions of Clerodendron glandulosumleaves extract against long term bilateral common carotid artery occlusion in rats
Publication date: May 2016 Source:Biomedicine & Pharmacotherapy, Volume 80 Author(s): Saritha Surapaneni, T. Prakash, MdAsif Ansari, PM. Manjunath, D. Kotresha, Divakar Goli Stroke is a major cause of death and disability worldwide. The resulting burden on the society continues to grow, with increase in the incidence of stroke. Oxidative stress has been involved in the pathogenesis of several neurological diseases including acute stroke.Focal and global cerebral ischemia represents diseases that are common in the human population.In recent years much attention is being paid towards the exploration of herbal...
Source: Biomedicine and Pharmacotherapy - March 19, 2016 Category: Drugs & Pharmacology Source Type: research

Study on cerebroprotective actions of Clerodendron glandulosumleaves extract against long term bilateral common carotid artery occlusion in rats.
Abstract Stroke is a major cause of death and disability worldwide. The resulting burden on the society continues to grow, with increase in the incidence of stroke. Oxidative stress has been involved in the pathogenesis of several neurological diseases including acute stroke.Focal and global cerebral ischemia represents diseases that are common in the human population.In recent years much attention is being paid towards the exploration of herbal preparation, antioxidant agents and combination therapies including COX-2 inhibitors in experimental model of stroke.Possible effect of a hydroalcoholic leaf extract of Cl...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 30, 2016 Category: Drugs & Pharmacology Authors: Surapaneni S, Prakash T, Ansari M, Manjunath P, Kotresha D, Goli D Tags: Biomed Pharmacother Source Type: research

Long-term consumption of fermented rooibos herbal tea offers neuroprotection against ischemic brain injury in rats.
In this study, we investigated the effects of long-term consumption of fermented rooibos herbal tea (FRHT) on ischemia/reperfusion (I/R)-induced brain injury in adult male Wistar rats. FRHT was administered to the animals ad libitum for 7 weeks prior to the induction of ischemic injury via a 20-minute bilateral occlusion of the common carotid arteries (BCCAO) followed by reperfusion for 24, 96 and 168 hours respectively. Neurobehavioural deficits, brain oedema, blood-brain barrier (BBB) damage, apoptosis, lipid peroxidation and total antioxidant capacity were subsequently evaluated using standard methods. Our results showe...
Source: Acta Neurobiologiae Experimentalis - April 6, 2017 Category: Neurology Authors: Akinrinmade O, Omoruyi S, Dietrich D, Ekpo O Tags: Acta Neurobiol Exp (Wars) Source Type: research

Standardization of rehabilitation program for post-apoplectic limb spasm treated by Tongjing Tiaoxing tuina and scalp acupuncture with physical therapy
Discussion: The Randomized Controlled Trial (RCT) mainly aim to evaluate the effectiveness and safety of traditional Chinese medicine rehabilitation program, by comparing the treatment of ZSTX with the PT for the treatment of limb spasm after stroke. Trial registration: Chinese Clinical Trial Registry: ChiCTR 1900024255. Registered on July 3, 2019.
Source: Medicine - May 1, 2020 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research

Anti-inflammatory effects of powdered product of Bu Yang Huan Wu decoction: Possible role in protecting against Transient Focal Cerebral Ischemia.
Authors: Chen KY, Wu KC, Hueng DY, Huang KF, Pang CY Abstract Bu Yang Huan Wu decoction (BYHW) is a traditional Chinese medicine (TCM) that consists of several herbs and has been used in patients with ischemic stroke for centuries. Although powdered formula of BYHW has widely been prescribed in clinic nowadays, evidence-based effectiveness and mechanism of action of BYHW powdered product in stroke remain to be characterized. Adult male Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) for 90 min followed by reperfusion for 24 h (ischemia/reperfusion; I/R) or sham surgery. After I/R, the ...
Source: International Journal of Medical Sciences - July 28, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury.
In this study, middle cerebral artery occlusion (MCAO) was induced in rats with thrombi generated by thread and subsequently treated with PN. After that, staining with 2,3,5-triphenyltetrazolium chloride was employed to evaluate the infarcted area, and electron microscopy was used to assess ultrastructural changes of the neurovascular unit. RNA-Seq was performed to determine the differential expressed genes (DEGs) which were then verified by qPCR. In total, 817 DEGs were identified to be related to the therapeutic effect of PN on stroke recovery. Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes an...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

The efficacy of Chinese herbal medicine Buyang Huanwu Decoction combined with acupuncture to treat sequela of apoplexy: A protocol for systematic review and meta-analysis
Conclusion: Buyang Huanwu Decoction combined with acupuncture seems to be an effective therapy to ameliorate the clinical symptoms of stroke sequelae. In order to further determine the effectiveness and safety of Buyang Huanwu Decoction combined with acupuncture in treating stroke sequelae, more multicenter and prospective randomized controlled trials must be carried out.
Source: Medicine - November 5, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

A Systematic Review and Meta-Analysis of the Effects of Herbal Medicine Buyang Huanwu Tang in Patients with Poststroke Fatigue
Evid Based Complement Alternat Med. 2021 Dec 14;2021:4835488. doi: 10.1155/2021/4835488. eCollection 2021.ABSTRACTPoststroke fatigue (PSF) is reported to occur in 30%-72% of all patients with stroke. PSF not only is a symptom of stroke but has also been reported to adversely affect the prognosis of patients with stroke. However, no treatment has had a significant effect on PSF. In East Asian countries, several herbal medicines have been used to treat stroke, with Buyang Huanwu Tang (BHT) being the most common. This review aimed to evaluate the efficacy and safety of BHT for PSF. A literature search was conducted on MEDLINE...
Source: Evidence-based Complementary and Alternative Medicine - December 24, 2021 Category: Complementary Medicine Authors: Chul Jin Seungwon Kwon Seung-Yeon Cho Seong-Uk Park Woo-Sang Jung Sang-Kwan Moon Jung-Mi Park Chang-Nam Ko Ki-Ho Cho Source Type: research