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Total 104 results found since Jan 2013.

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Recombinant Human Milk Fat Globule-Epidermal Growth Factor 8 Attenuates Microthrombosis after Subarachnoid Hemorrhage in Rats
This study investigated the effects of recombinant human milk fat globule-epidermal growth factor 8 on microthrombosis and neurological function after subarachnoid hemorrhage.
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2019 Category: Neurology Authors: Jikai Wang, Yuchun Zuo, Kai Zhuang, Kui Luo, Xiaoxin Yan, Jianming Li, John H. Zhang, Fei Liu Source Type: research

Association of cardiovascular diseases with milk intake among general Chinese adults.
CONCLUSIONS: Daily milk intake was associated with lower risk of CVD incidence and mortality in a linear inverse relationship. The findings provide new evidence for dietary recommendations in CVD prevention among Chinese adults and people with similar dietary pattern in other countries. PMID: 32304403 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - April 14, 2020 Category: General Medicine Authors: Wang XY, Liu FC, Yang XL, Li JX, Cao J, Lu XF, Huang JF, Li Y, Chen JC, Zhao LC, Shen C, Hu DS, Zhao YX, Yu L, Liu XQ, Wu XP, Gu DF Tags: Chin Med J (Engl) Source Type: research

Featured Review: Taxation of the fat content of foods for reducing their consumption and preventing obesity or other adverse health outcomes
ConclusionsWe did not find enough reliable evidence to find out whether a tax on the fat content of foods resulted in people eating less fat, or less saturated fat.We did not find any evidence about how a tax on the fat content of foods affected obesity or overweight.The results of our review will change when further evidence becomes available.Discussing the findings of this review, lead author Stefan Lhachimi said, “A tax on saturated fats could be in principle a good approach to reduce the consumption of so-called junk foods, a group of food products which is fiendishly tricky to define in legal terms. By taxing a main...
Source: Cochrane News and Events - September 7, 2020 Category: Information Technology Authors: Rachel Klabunde Source Type: news

Nutritional Status and Risks of Cognitive Decline and Incident Neurocognitive Disorders: Singapore Longitudinal Ageing Studies
ConclusionThe ENIGMA measure of global malnutrition risk predicts cognitive decline and incident neurocognitive disorders, suggesting the feasibility of identifying vulnerable subpopulations of older adults for correction of malnutrition risk to prevent neurocognitive disorders.
Source: The Journal of Nutrition, Health and Aging - February 16, 2021 Category: Nutrition Source Type: research

Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

New Analyses Suggest Favorable Results for STELARA ® (ustekinumab) When Used as a First-Line Therapy for Bio-Naïve Patients with Moderately to Severely Active Crohn’s Disease and Ulcerative Colitis
SPRING HOUSE, PENNSYLVANIA, October 25, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced data from two new analyses of STELARA® (ustekinumab) for the treatment of adults with moderately to severely active Crohn’s disease (CD) and ulcerative colitis (UC).1,2 In a modelled analysisa focused on treatment sequencing using data from randomized controlled trials, network meta-analysis and literature, results showed patient time spent in clinical remission or response was highest when STELARA was used as a first-line advanced therapy for bio-naïve patients with moderately to severely acti...
Source: Johnson and Johnson - October 25, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Fibonacci ’ s Tree – Winner of Hysteria 2013
Fibonacci’s Tree by Tracy Fells ‘Here I am!’ I jab a finger, one of the few that still works, at the notebook page. ‘Right at the bottom of the tree.’ Tanya is adding too much milk to my tea. She doesn’t think I’m looking when she shoves a custard cream into her mouth. It disappears whole like an envelope propelled through a gaping letterbox. Crumbs splutter across the back of my useless left hand as she chants, ‘Teatime, Ellie. Sorry, we’re out of custard creams, but I’ve saved you a Bourbon. They’re your favourites.’ I can hear the words inside my head. They are crisp and clear like Mum’s be...
Source: The Hysterectomy Association - December 5, 2013 Category: OBGYN Authors: Linda Parkinson-Hardman Tags: Hysteria hysteria 2 hysteria 2013 hysteria winners short story Source Type: news

Drinking Black Tea May Lower Mortality Risk, Study Suggests
While green tea has a long-standing reputation for health benefits, research has been much more mixed on black tea. One problem, says Maki Inoue-Choi, an epidemiologist at the National Cancer Institute, is that large observational studies on tea and mortality have focused on countries like Japan or China—places where green tea is more popular. To fill this gap, Inoue-Choi and her colleagues analyzed data in the United Kingdom, where black tea drinking is common. After surveying about 500,000 people and following them for a median of 11 years, the results, published Aug. 29 in the journal Annals of Internal Medicine, ...
Source: TIME: Health - August 29, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

How to Lower Your Cholesterol Naturally
In the years following World War II, physicians in the U.S. and Europe noticed a surprising phenomenon: rates of heart attack and stroke fell dramatically in many places. Autopsies from this period also revealed reduced rates of atherosclerosis, which is a buildup of fatty arterial plaques that causes cardiovascular disease. At first, experts were perplexed. But as time passed, many concluded that wartime food deprivations and the forced shifts in people’s diets—namely, big reductions in the consumption of red meat and other animal products—contributed to the heart-health improvements. Later work, particu...
Source: TIME: Health - August 30, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

Milk Bad, Cheese Not? Dairy Products Tied to Different CVD Risks Milk Bad, Cheese Not? Dairy Products Tied to Different CVD Risks
In patients with angina, higher dairy and milk intake were linked to elevated risk of stroke and death, butter a higher risk for AMI, but cheese was tied to lower AMI risk, in an observational study.Medscape Medical News
Source: Medscape Pulmonary Medicine Headlines - October 24, 2022 Category: Respiratory Medicine Tags: Cardiology News Source Type: news

Too Little Sleep Destroys DNA?
I talk to my patients about the danger of not sleeping all the time. Unfortunately, it’s a common problem that affects 75 million Americans. People who don’t sleep, or sleep poorly, have up to 400% more accidents that those who get a good night’s rest. Not getting enough sleep also increases your risk of developing chronic diseases. Studies, including a large meta-analysis of 470,000 adults, found that those who slept less than six hours developed a:1,2,3,4,5 48% increase in the incidence of coronary heart disease 30% increased risk of dementia 15% increase in the incidence of stroke 50% cancer risk 17% higher risk ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news