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Improving Microcirculatory Reperfusion Reduces Parenchymal Oxygen Radical Formation and Provides Neuroprotection Basic Sciences
Conclusions—Promoting microvascular reperfusion by protecting vasculature can secondarily reduce parenchymal ROS formation and provide neuroprotection. The model presented can be used to directly assess pharmacological end points postulated in brain parenchyma and vasculature in vivo.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Aslihan Taskiran-Sag, Muge Yemisci, Yasemin Gursoy-Ozdemir, Sefik Evren Erdener, Hulya Karatas, Deniz Yuce, Turgay Dalkara Tags: Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Impact of hydroxytyrosol on stroke: tracking therapy response on neuroinflammation and cerebrovascular parameters using PET-MR imaging and on functional outcomes
Conclusion: An HT-enriched diet significantly increased the number of Iba-1+ microglia/macrophages in the post-ischemic area, inducing higher expression of anti-inflammatory markers while no clear-cut effect was observed. Also, HT did not affect recovery of the cerebrovascular parameters, including ADC and CBF.Altogether, our data indicated that a prolonged dietary intervention with HT, as a single component of the Mediterranean diet, induces molecular changes that may improve stroke outcomes. Therefore, we support the use of the Mediterranean diet as a multicomponent therapy approach after stroke.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Cristina Barca, Maximilian Wiesmann, Jes ú s Calahorra, Lydia Wachsmuth, Christian D ö ring, Claudia Foray, Ali Heiradi, Sven Hermann, Maria Á ngeles Peinado, Eva Siles, Cornelius Faber, Michael Sch ä fers, Amanda J Kiliaan, Andreas H. Jacobs, Bastian Tags: Research Paper Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject.Graphical abstract
Source: Biomedicine and Pharmacotherapy - February 4, 2020 Category: Drugs & Pharmacology Source Type: research

Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization.
In conclusion, our study indicated the cerebral protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to its potential to the reduction of neuroinflammatory response in a stroke subject. PMID: 32028240 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 2, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Xiao G, He S, Liu X, Zhu L, Yang X, Zhang Y, Orgah J, Feng Y, Wang X, Zhang B, Zhu Y Tags: Biomed Pharmacother Source Type: research

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?
This study demonstrated unaltered vascular conductance in response to lumbar sympathetic stimulation in CIH-exposed rats. Aortic compliance was increased and estimated blood volume was unchanged in CIH-exposed rats. Increased blood pressure was related to an increase in cardiac output, which was confirmed by echocardiography (Lucking et al., 2014). It is suggested therefore that hypertension in the CIH model can be evoked by over-excitation of the cardiac arm of sympathetic nervous system (SNS), even before mechanisms of enhanced peripheral vasoconstriction and endothelial dysfunction are initiated (Naghshin et al., 2009)....
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Oxidation ‑reduction potential parameters worsen following intraarterial therapy in patients with reduced collateral circulation and middle cerebral artery occlusions
In conclusion, upon patient admission, the ORP parameters were not significantly different between the collateral circulation status groups for MCA occlusions. The ORP parameters worsened after IAT regardless of the collateral circulation status; however, after IAT, on day 2, patients with good collaterals experienced less oxidative stress (sORP) and had higher antioxidant reserves (cORP) than patients with reduced collaterals.PMID:37229324 | PMC:PMC10203750 | DOI:10.3892/etm.2023.11994
Source: Experimental and Therapeutic Medicine - May 25, 2023 Category: General Medicine Authors: Benjamin Atchie Stephanie Jarvis Richard Bellon Trevor Barton Lauren Disalvo Kristin Salottolo Raphael Bar-Or David Bar-Or Source Type: research

Clinical and Basic Evaluation of the Prognostic Value of Uric Acid in Traumatic Brain Injury.
Conclusions: UA acted to attenuate neuronal loss, cerebral perfusion impairment and neurological deficits in TBI mice through suppression of neuronal and vascular oxidative stress. Following TBI, active antioxidant defense in the brain may result in consumption of UA in the serum, and thus, a decreased serum UA level could be predictive of good clinical recovery. PMID: 30013449 [PubMed - in process]
Source: International Journal of Medical Sciences - July 18, 2018 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function
AbstractMitochondrial dysfunction has a recognised role in the progression of Alzheimer's disease (AD) pathophysiology. Cerebral perfusion becomes increasingly inefficient throughout ageing, leading to unbalanced mitochondrial dynamics. This effect is exaggerated by amyloid β (Aβ) and phosphorylated tau, two hallmark proteins of AD pathology. A neuroprotective role for the adipose‐derived hormone, leptin, has been demonstrated in neuronal cells. However, its effects with relation to mitochondrial function in AD remain largely unknown. To address this question, we h ave used both a glucose‐serum deprived (CGSD) model ...
Source: Journal of Neurochemistry - March 13, 2020 Category: Neuroscience Authors: Ying Cheng, Matthew Buchan, Karina Vitanova, Laura Aitken, Frank J Gunn ‐Moore, Rona R. Ramsay, Gayle Doherty Tags: ORIGINAL ARTICLE Source Type: research