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Nutrition: Antidoxidants

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Total 1078 results found since Jan 2013.

Tyrosol as a neuroprotector: strong effects of a "weak" antioxidant.
Abstract The use of neuroprotective agents for stroke is pathogenetically justified, but the translation of results of preclinical studies of neuroprotectors into clinical practice has been a noticeable failure. One of the leading reasons for these failures is the one-target mechanism of their activity. p-Tyrosol (Tyr), a biophenol, is present in a variety of natural sources, mainly in foods, such as olive oil and wine. Tyr has a wide spectrum of biological activity: antioxidant, stress-protective, anti-inflammatory, anticancer, cardioprotective, neuroprotective and many others. This review analyzes data on the ne...
Source: Current Neuropharmacology - May 5, 2020 Category: Drugs & Pharmacology Authors: Plotnikov MB, Plotnikova TM Tags: Curr Neuropharmacol Source Type: research

Promotion of Momordica Charantia polysaccharides on neural stem cell proliferation by increasing SIRT1 activity after cerebral ischemia/reperfusion in rats
Brain Res Bull. 2021 Feb 26:S0361-9230(21)00058-7. doi: 10.1016/j.brainresbull.2021.02.016. Online ahead of print.ABSTRACTThe deacetylase SIRT1 has been reported to play a critical role in regulating neurogenesis, which may be an adaptive processes contributing to recovery after stroke. Our previous work showed that the antioxidant capacity of Momordica charantia polysaccharides (MCPs) could protect against cerebral ischemia/reperfusion (I/R) after stroke. However, whether the protective effect of MCPs on I/R injury is related to NSCs proliferation remains unclear. In the present study, we designed in vivo and in vitro exp...
Source: Brain Research Bulletin - March 1, 2021 Category: Neurology Authors: Juyun Ma Haidi Fan Heng Cai Zhaoli Hu Xiaoling Zhou Fengying Li Hansen Chen Jiangang Shen Suhua Qi Source Type: research

Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1 α, NF-κB, and VEGF pathways
ConclusionThese findings suggest that acteoside possess potent anti-stroke activity through modulation of HIF-1 α, NF-κB, and VEGF pathway along with its potent antioxidant activity.Graphic abstract
Source: Inflammopharmacology - August 7, 2021 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of wild lowbush blueberry (Vaccinium angustifolium) on global cerebral ischemia/reperfusion injury in rats: Downregulation of iNOS/TNF- α and upregulation of miR-146a/miR-21 expression
This study aims to investigate the neuroprotective effect of wild lowbush blueberry on CIRI in rats. Accordingly, CIRI and reperfusion were induced in rats for 60 min and 24 h, respectively. Then, the mechanisms of the neuroprotective effects of BBE were investigated in the injury through evaluating miR-146a, miR-21, and their targets in a CIRI rat model. After that, the BBE (30, 60, and 120 mg/kg b.wt) was intraperitoneally injected for 14 days, then CIRI was induced by BCCAO for 60 min for ischemic stroke and reperfusion for 24 h. Several parameters including the oxidative stress levels in the hippocampus and serum were ...
Source: Cell Research - September 28, 2021 Category: Cytology Authors: Zahra Moradi Zahra Rabiei Maryam Anjomshoa Zeinab Amini-Farsani Vahid Massahzadeh Samira Asgharzade Source Type: research

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery
Behav Neurol. 2022 Apr 16;2022:4825472. doi: 10.1155/2022/4825472. eCollection 2022.ABSTRACTStroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) ...
Source: Behavioural Neurology - April 26, 2022 Category: Neurology Authors: Bahareh Jafari Mahmoud Gharbavi Yasamin Baghdadchi Hamidreza Kheiri Manjili Javad Mahmoudi Iraj Jafari-Anarkoli Shayan Amiri Mir-Jamal Hosseini Source Type: research

Antihypertension effect of astragaloside  IV during cerebral ischemia reperfusion in rats
In conclusion, astragaloside IV may alleviate CIR injury partially by lowering systemic blood pressure.PMID:36331022 | DOI:10.3892/mmr.2022.12890
Source: Molecular Medicine - November 4, 2022 Category: Molecular Biology Authors: Fengyan Shen Yong Meng Yuhai He Bowan Huang Jinxin Huang Lu Wang Source Type: research

Tetramethylpyrazine alleviates mitochondrial abnormality in models of cerebral ischemia and oxygen/glucose deprivation Reoxygenation
Exp Neurol. 2023 Jun 10:114468. doi: 10.1016/j.expneurol.2023.114468. Online ahead of print.ABSTRACTTraditional herbal medicine Ligusticum wallichii Franchat (Chuan Xiong) is frequently prescribed and highly recommended to patients with stroke. Rodent studies have demonstrated the neuroprotective effects of its active component tetramethylpyrazine against post-stroke brain injury and highlighted its role in antioxidant, anti-inflammation, and anti-apoptosis activity. Using permanent cerebral ischemia in rats and oxygen/glucose deprivation and reoxygenation (OGDR) in rat primary neuron/glia cultures, this study sheds light ...
Source: Experimental Neurology - June 12, 2023 Category: Neurology Authors: Cheng-Yi Chang Chih-Cheng Wu Pin-Ho Pan Ya-Yu Wang Shih-Yi Lin Su-Lan Liao Wen-Ying Chen Yu-Hsiang Kuan Chun-Jung Chen Source Type: research

Gastrodin Alleviates Cerebral Ischemic Damage in Mice by Improving Anti-oxidant and Anti-inflammation Activities and Inhibiting Apoptosis Pathway.
Abstract Gastrodin (GAS), an active constituent of the Chinese herbal medicine Tianma, has anti-oxidant and anti-inflammation activities but its protective effect to the prevention of neurotoxicity induced by ischemic stroke is unclear. In the present study, middle cerebral artery occlusion (MCAO) was used to establish a mice ischemic stroke model. Infarct volume ratio and neurobehavioral score were evaluated, Nissl staining was performed and the expression of cleaved Caspase 3, Bax and B cell lymphoma 2 (Bcl-2) were assessed at 24 h or 7 days after reperfusion. In addition, the total superoxide dismutase (SOD) ...
Source: Neurochemical Research - January 13, 2015 Category: Neuroscience Authors: Peng Z, Wang S, Chen G, Cai M, Liu R, Deng J, Liu J, Zhang T, Tan Q, Hai C Tags: Neurochem Res Source Type: research