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Total 94 results found since Jan 2013.

Study Shows Value of Calcium Scan in Predicting Heart Attack and Stroke Among Those Considered at Either Low or High Risk - 12/23/13
A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person’s risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery.
Source: Johns Hopkins Medicine News - December 23, 2013 Category: Research Source Type: news

Study shows value of calcium scan in predicting heart attack, stroke among those considered at risk
A new study shows that coronary artery calcium (CAC) screening, an assessment tool that is not currently recommended for people considered at low risk, should play a more prominent role in helping determine a person's risk for heart attack and heart disease-related death, as well as the need for angioplasty or bypass surgery. CAC screening provides a direct measure of calcium deposits in heart arteries and is easily obtained on a computed tomography (CT) scan."We showed that by using only the traditional risk factors, we miss a significant percentage of individuals at high risk.
Source: Health News from Medical News Today - December 27, 2013 Category: Consumer Health News Tags: Cardiovascular / Cardiology Source Type: news

Voltage Gated Calcium Channels Antibody-Associated Autoimmune Encephalitis (P5.228)
ConclusionThis case demonstrates a correlation between a high titer of VGCC antibodies and autoimmune encephalitis. Our patient's initial improvement with steroids and plasma exchange in the face of a negative CT and PET suggests a primary autoimmune process rather than a paraneoplastic etiology, though we admit that it is premature to rule out remission and we will continue to follow herDisclosure: Dr. Alwaki has nothing to disclose. Dr. Lugo has nothing to disclose. Dr. Goshgarian has nothing to disclose. Dr. Ahmad has nothing to disclose. Dr. Hefzy has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alwaki, A., Lugo, A., Goshgarian, C., Ahmad, O., Hefzy, H., Mitsias, P. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Creutzfeldt-Jakob Disease and Subacute Encephalopathies Source Type: research

Volumetric analysis of central body fat accurately predicts incidence of diabetes and hypertension in adults
Conclusions Central body fat and BMI equally and highly predict incidence of hypertension and type 2 diabetes.
Source: BMC Obesity - February 25, 2015 Category: Eating Disorders and Weight Management Source Type: research

New Insights from Major Prospective Cohort Studies with Cardiovascular Magnetic Resonance (CMR)
Abstract Since 1948, epidemiology studies played an important role in understanding cardiovascular disease and afforded an opportunity to learn about newer diagnostic tests. In 2000, the MESA Study incorporated several advanced cardiovascular imaging modalities including cardiac magnetic resonance imaging (MRI) and coronary artery calcium scans. The decade of follow-up enabled prognosis studies, an important step beyond association studies. In brief, left ventricular hypertrophy by cardiac MRI predicted incident heart failure and stroke. In the MESA Study, coronary artery calcium was a better predictor of coronar...
Source: Current Cardiology Reports - May 5, 2015 Category: Cardiology Source Type: research

Therapeutic hypothermia for acute brain injuries
Therapeutic hypothermia, recently termed target temperature management (TTM), is the cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years of basic and clinical evidence support its therapeutic value. Although hypothermia decreases the metabolic rate to restore the supply and demand of O2, it has other tissue-specific effects, such as decreasing excitotoxicity, limiting inflammation, preventing ATP depletion, reducing free radical production and also intracellular calcium overload to avoid apoptosis. Currently, mild hypothermia (33°C) has become a standard in post-resuscitative care...
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - June 5, 2015 Category: Emergency Medicine Authors: Max AndresenJose GazmuriArnaldo MarínTomas RegueiraMaximiliano Rovegno Source Type: research

Sleep Problems May Hint At Future Heart Disease Risk
By Kathryn Doyle (Reuters Health) - Adults who get too much or too little sleep may have the beginnings of “hardening" of the arteries, which can be an early sign of heart disease, according to a new study. “Many people, up to one third or one fourth of the general population, suffer from inadequate sleep – either insufficient duration of sleep or poor quality of sleep,” said co-lead author Dr. Chan-Won Kim of Kangbuk Samsung Hospital of Sungkyunkwan University School of Medicine in Seoul, South Korea. Several studies have linked inadequate sleep with an increased risk of heart attack and stroke, bu...
Source: Healthy Living - The Huffington Post - September 10, 2015 Category: Consumer Health News Source Type: news

Combining patient proteomics and in vitro cardiomyocyte phenotype testing to identify potential mediators of heart failure with preserved ejection fraction
Conclusions: Platelets may harbor proteins associated with HFpEF. S100A8 is present in the platelets of subjects with HFpEF and increased in the plasma of the same subjects. We further established a bedside-to-bench translational system that can be utilized as a secondary screen to ascertain whether the biomarkers may be an associated finding or causal to the disease process. S100A8 has been linked with other cardiovascular disease such as atherosclerosis and risk for myocardial infarction, stroke, or death. This is the first report on association of S100A8 with HFpEF.
Source: Journal of Translational Medicine - January 20, 2016 Category: Research Authors: Roseanne RaphaelDiana PurushothamCourtney GastonguayMarla ChesnikWai-Meng KwokHsiang-En WuSanjiv ShahShama MirzaJennifer Strande Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function.  >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news

Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus.
This study was to reveal the mechanisms by which baicalin protected hippocampal neurons and improved learning and memory impairment after global cerebral ischemia/reperfusion in gerbil. In the present study, the Morris water maze test showed that baicalin significantly improved learning and memory impairment after global cerebral ischemia/reperfusion in gerbils. Laser scanning confocal fluorescence microscope examination showed that baicalin suppressed OGD-induced augmentation of intracellular calcium concentration. Western blotting analysis indicated that baicalin suppressed ischemia-caused elevated phosphorylation level ...
Source: Brain Research - March 21, 2016 Category: Neurology Authors: Wang P, Cao Y, Yu J, Liu R, Bai B, Qi H, Zhang Q, Guo W, Zhu H, Qu L Tags: Brain Res Source Type: research

Cost-effectiveness analysis of new generation coronary CT scanners for difficult-to-image patients
ConclusionThe use of NGCCT might be considered cost-effective in both populations since it is cost-saving compared to ICA and generates similar effects.
Source: The European Journal of Health Economics - September 19, 2016 Category: Health Management Source Type: research

Visual estimate of coronary artery calcium predicts cardiovascular disease in COPD
Conclusions A simple visual score for CAC performs well in predicting prevalent CAD and incident CVD in smokers with and without COPD.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Bhatt, S., Kazerooni, E., Newell, J., Hokanson, J., Budoff, M., Dass, C., Bodduluri, S., Jacobson, F., Yen, A., Dransfield, M., Fuhrman, C., Tashjian, J., Nath, H. Tags: 1.12 Clinical Problems - COPD Source Type: research

Extracranial internal carotid artery calcium volume measurement using computer tomography.
CONCLUSIONS: Compared to automated method, the semi-automated method for calcium volume is acceptable and closer to manual strategy for calcium volume. Further work evaluating and confirming the performance of our semi-automated protocol is now warranted. PMID: 28541017 [PubMed - as supplied by publisher]
Source: International Angiology - May 26, 2017 Category: Cardiology Tags: Int Angiol Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question ...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news

The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine.
Abstract It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. This project will examine the effect of microneedle rollers on the transport of DH and PE across pig ear skin. The use of the transcutaneous route of administration reduces and in sometimes eliminates the trau...
Source: Current Drug Delivery - July 30, 2018 Category: Drugs & Pharmacology Authors: Luu E, Ita KB, Morra MJ, Popova IE Tags: Curr Drug Deliv Source Type: research