Summary: International Kidney Cancer Symposium

Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found athttp://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO1, FoxO3, FoxO4 and FoxO6. FoxO1/3/4 are regulated by PI3K– AKT signaling. Inhibits cell survival and proliferation.  Promotes apoptosis and cell cycle arrest in mammalian cell culture systems, putative tumor suppressor role.  In mouse models somatic deletion of TSC1 leads to the development of polycystic kidney and renal tumor.  Dual inactivation of FoxO and TSC1 dramatically drives renal tumor progression.  FoxOs are extinguished in the majority of human renal tumor samples.  Broad somatic deletion of all 3 FoxOs was shown to engender a cancer-prone condition dominated by hemangiomas and lymphomas. Myc signaling is the key downstream effector of FoxOs in the regulation of renal tumorigenesis. A combination therapy to target both mTOR and FoxO is suggested in human RCC.  mTORC1:  hyperactivation...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

Related Links:

We report a rare case of 74-year-old female of primary hyperparathyroidism caused by parathyroid carcinoma (PC) and coexisting multiple parathyroid adenomas. She was referred to our hospital for primary hyperparathyroidism and a suspected thyroid tumor. She had no family history of malignant tumor. Computed tomography (CT) and ultrasonography of the neck revealed some masses posterior to both thyroid lobes. Those masses were believed to be parathyroid lesions. However, another mass located posterior to the right upper thyroid lobe seemed to be heterogeneous, which indicated a malignant thyroid tumor as well as parathyroid ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
We describe a unique, complex case of a man resulted affected by both APS-2 and MEN-2a. The patient developed Hashimoto's thyroiditis, diabetes mellitus type 1 and AAD, despite testing negative for adrenal cortex autoantibodies (ACA) and steroid 21-hydroxylase autoantibodies (21-OHAb). Moreover, he had also a family history for MEN-2a and he first developed medullay thyroid cancer, then bilateral pheochromocytoma on the adrenal substrate of an AAD. On adrenal histology we found complete bilateral cortical atrophy in the presence of a lymphocytic infiltration and fibrosis, confirming an ACA and 21-OHAb-negative AAD. This da...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
CONCLUSIONS: The ATA risk stratification system is a reliable predictor of short-term outcomes in patients with DTC in real-world clinical settings characterized by center heterogeneity in terms of size, location, level of care, local management strategies, and resource availability. PMID: 32475305 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
In conclusion, we suggest that in the presence of intolerance or resistance to colchicine, interleukin (IL)-1 inhibition could suppress peritoneal inflammation and prevent MSTs. PMID: 32477360 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Front Immunol Source Type: research
CONCLUSION: Inpatient consultations is very useful to the patient and managing physician. Although a better knowledge in the identification of common ophthalmic conditions can help to reduce the number of inpatient consults from other medical specialties. PMID: 32476114 [PubMed - in process]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: West Afr J Med Source Type: research
Authors: Chuling F, Qian Z, Na W, Xiaoyan J, Zuojun X Abstract Background: Pulmonary sarcoidosis patients who get disease progression despite corticosteroid treatment or can't tolerate corticosteroid required second-line drug. Methotrexate (MTX) is the most widely used in our clinical practice. Data on its safety and efficacy at different doses are still limited, especially for those without folic acid supplements. Objective: To report effectiveness of different MTX dosages and tolerability of MTX in pulmonary sarcoidosis without folic acid supplements. Methods: A retrospective study on pulmonary sarcoidosi...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
Conclusions: MPO-ANCA-positive patients with ILD do not show the typical UIP pattern as seen in patients with idiopathic pulmonary fibrosis on surgical lung biopsy. PMID: 32476954 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
Conclusions: According to this study, ventilatory limitation, pulmonary involvement, and deconditioning are the main causes of activity limitations in sarcoidosis patients. PMID: 32476953 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
Conclusion: Addition of rhTM to CS, and a low initial CS maintenance dose (0.5 mg/kg), were associated with better 3-month survival in patients with AE-IPF. PMID: 32476952 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research
Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found at http://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
More News: Allergy & Immunology | Alopecia | Anaphylactic Shock | Anemia | Anorexia | Anxiety | Avastin | Beta-Blockers | Biology | Bleeding | Calcium | Cancer | Cancer & Oncology | Cancer Therapy | Carcinoma | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chronic Kidney Disease | Chronic Obstructive Pulmonary | Chronic Pain | Clinical Trials | Corticosteroid Therapy | CT Scan | Dermatology | Diabetes | Diabetes Mellitus | Diabetes Type 1 | Diets | Diphenoxylate | Eating Disorders & Weight Management | Education | Emergency Medicine | Endocrinology | Environmental Health | Epidemiology | Fortamet | Genetics | Heart | Heart Attack | Heart Failure | Hemangioma | Hemorrhagic Stroke | Hypertension | Immunotherapy | Imodium | Intensive Care | Ischemic Stroke | Kidney Cancer | Laparoscopy | Loperamide | Lymphoma | Metformin | Minimally Invasive Surgery | Molecular Biology | Nephrectomy | Netherlands Health | Nurses | Nursing | Nutrition | Onychomycosis | Oral Cancer | Pain | Pain Management | Pancreas | Pancreatic Cancer | Pathology | PET Scan | Pneumothorax | Polycystic Kidney Disease | Probiotics | Renal Cell Carcinoma | Skin | Skin Biopsy | Smokers | Sodium | Stroke | Study | Tarceva | Thrombocytopenia | Thyroid | Thyroid Cancer | Toxicology | Universities & Medical Training | Ureter and Renal Pelvis Cancer | Urology & Nephrology