Summary: International Kidney Cancer Symposium

Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found athttp://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO1, FoxO3, FoxO4 and FoxO6. FoxO1/3/4 are regulated by PI3K– AKT signaling. Inhibits cell survival and proliferation.  Promotes apoptosis and cell cycle arrest in mammalian cell culture systems, putative tumor suppressor role.  In mouse models somatic deletion of TSC1 leads to the development of polycystic kidney and renal tumor.  Dual inactivation of FoxO and TSC1 dramatically drives renal tumor progression.  FoxOs are extinguished in the majority of human renal tumor samples.  Broad somatic deletion of all 3 FoxOs was shown to engender a cancer-prone condition dominated by hemangiomas and lymphomas. Myc signaling is the key downstream effector of FoxOs in the regulation of renal tumorigenesis. A combination therapy to target both mTOR and FoxO is suggested in human RCC.  mTORC1:  hyperactivation...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news

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Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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We describe the most highly recommended generic and disease-specific PRO tools in SCD and discuss the challenges of incorporating them in clinical practice. EXPERT OPINION: PRO measures are essential to incorporate into SCD clinical trials either as primary or secondary outcomes. The use of PRO measures in SCD facilitates a patient-centered approach, which is likely to lead to improved outcomes. Significant challenges remain in adapting PRO tools to routine clinical use and in developing countries. PMID: 33034214 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
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Conclusions VHL/PBRM1 mutations confirmed 3rd subtype identified and under review but appears to be mis-classified tumors.  Shows value of molecular methods rather than new mechanistic insights. Integration with survival outcome—suggests molecular detailing can be prognostic Full integrative analysis in process Preliminary data can be found at http://tcga-data.nci.hih.gov/tcga/ FoxO Transcription Factors in mTORC1- Activated Renal Tumorigenesis:  Implications for the RCC Treatment Boyi Gan, MD Anderson Cancer Center FoxO Family Transcription Factors:  mammals possess FoxO...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
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