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Total 269 results found since Jan 2013.

The interneuron energy hypothesis: implications for brain disease.
Abstract Fast-spiking, inhibitory interneurons - prototype is the parvalbumin-positive (PV+) basket cell - generate action potentials at high frequency and synchronize the activity of numerous excitatory principal neurons, such as pyramidal cells, during fast network oscillations by rhythmic inhibition. For this purpose, fast-spiking, PV+ interneurons have unique electrophysiological characteristics regarding action potential kinetics and ion conductances, which are associated with high energy expenditure. This is reflected in the neural ultrastructure by enrichment with mitochondria and cytochrome c oxidase, indi...
Source: Neurobiology of Disease - August 15, 2015 Category: Neurology Authors: Kann O Tags: Neurobiol Dis Source Type: research

Sweet and brittle — Diabetes mellitus and the skeleton
Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a medical mass phenomenon in many parts of the world. Unrestricted access to a high-carbohydrate/high-fat diet in combination with considerably higher energy uptake compared to expenditure has led to a pandemic of the metabolic syndrome and T2DM in many countries. Vascular complications resulting from T2DM include nephropathy, neuropathy and retinopathy as well as ischemic heart disease, peripheral vascular disease and stroke.
Source: Bone - September 9, 2015 Category: Orthopaedics Authors: Lorenz C. Hofbauer, Beata Lecka-Czernik, Markus J. Seibel Tags: Editorial Source Type: research

Impact On Italian National Health Service Expenditure For The Treatment Of Venous Thromboembolism With Rivaroxaban
This study aims to evaluate the economic impact of the use of rivaroxaban for preventing DVT and PE in Italy.
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: A Roggeri, DP Roggeri, V Pengo Source Type: research

Health Outcomes Evaluation Of New Technologies In Clinical Practice: The Case Of The Minimally Invasive Insertable Cardiac Monitor
The Medical Devices Committee (MDC) of the Maggiore Policlinico Hospital in Milan, Italy, approved the use of a minimally invasive insertable cardiac monitor (ICM). ICMs are leadless subcutaneous devices that continuously monitor the heart rhythm and record events, allowing for the diagnosis of infrequent rhythm abnormalities that can be the cause of palpitations, syncope and stroke. Given the limited available literature and foreseen increase in expenditure, the MDC established an outcome monitoring process in order to test the effectiveness of the device in real practice in detecting abnormal heart rhythms and therefore ...
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: F Venturini, MR Magrì, F Ambrosini, MC, Politano C Lodi, F Lombardi Source Type: research

Sensors, Vol. 16, Pages 18: Inertial Sensor Technology for Elite Swimming Performance Analysis: A Systematic Review
Technical evaluation of swimming performance is an essential factor of elite athletic preparation. Novel methods of analysis, incorporating body worn inertial sensors (i.e., Microelectromechanical systems, or MEMS, accelerometers and gyroscopes), have received much attention recently from both research and commercial communities as an alternative to video-based approaches. This technology may allow for improved analysis of stroke mechanics, race performance and energy expenditure, as well as real-time feedback to the coach, potentially enabling more efficient, competitive and quantitative coaching. The aim of this paper is...
Source: Sensors - December 25, 2015 Category: Biotechnology Authors: Robert MooneyGavin CorleyAlan GodfreyLeo QuinlanGearóid ÓLaighin Tags: Review Source Type: research

Increased Resting Energy Expenditure after Endovascular Coiling for Subarachnoid Hemorrhage
Appropriate nutritional care from the acute stage is essential for improved functional outcomes and reduced mortality in patients with subarachnoid hemorrhage (SAH). Although endovascular coiling is increasingly being used as an alternative to neurosurgical clipping and craniotomy for ruptured aneurysms, the resting energy expenditure (REE) of patients treated with this new technique has not been systemically evaluated.
Source: Journal of Stroke and Cerebrovascular Diseases - January 18, 2016 Category: Neurology Authors: Ayano Nagano, Yoshitaka Yamada, Hiroji Miyake, Kazuhisa Domen, Tetsuo Koyama Source Type: research

Update on atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and accounts for one-third of hospitalizations for rhythm disorders in the United States [1]. Atrial fibrillation is of public health importance and profoundly increases morbidity, mortality, and health-related expenditures. Morbidities include outcomes such as heart failure, stroke and the deleterious effects on quality of life (QOL), functional status, and cognition. In the United States and Western Europe, the aging population and the accompanying rise in the prevalence of AF have magnified its toll on morbidity and healthcare costs.
Source: Trends in Cardiovascular Medicine - June 21, 2016 Category: Cardiology Authors: Amanulla Khaji, Peter R. Kowey Source Type: research

Exome sequencing in Thai patients with familial obesity.
Abstract Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have identified several genes associated with obesity, including LEP, LEPR, POMC, PCSK1, FTO, MC3R, MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B, SIM1, and TNKS/MSRA. However, most of these variants are found in t...
Source: Genetics and Molecular Research - July 16, 2016 Category: Genetics & Stem Cells Authors: Kaewsutthi S, Santiprabhob J, Phonrat B, Tungtrongchitr A, Lertrit P, Tungtrongchitr R Tags: Genet Mol Res Source Type: research

Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
Publication date: Available online 27 June 2016 Source:Japanese Dental Science Review Author(s): Yosuke Yamawaki, Kana Oue, Satomi Shirawachi, Satoshi Asano, Kae Harada, Takashi Kanematsu Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with ch...
Source: Japanese Dental Science Review - July 27, 2016 Category: Dentistry Source Type: research

Update on atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia and accounts for one-third of hospitalizations for rhythm disorders in the United States [1]. Atrial fibrillation is of public health importance and profoundly increases morbidity, mortality, and health-related expenditures. Morbidities include outcomes such as heart failure, stroke and the deleterious effects on quality of life (QOL), functional status, and cognition. In the United States and Western Europe, the aging population and the accompanying rise in the prevalence of AF have magnified its toll on morbidity and healthcare costs.
Source: Trends in Cardiovascular Medicine - June 21, 2016 Category: Cardiology Authors: Amanulla Khaji, Peter R. Kowey Source Type: research

One Hour of Exercise Can Offset Prolonged Sitting
A typical day for many people includes at least 8 hours of sitting - driving to work, sitting in an office, driving home, and watching TV. An international study of more than 1 million people shows that one hour of moderate physical activity can eliminate the health risks associated with sedentary behavior. The study forms the first part of a four-paper series published by The Lancet that provides an overview and update of worldwide trends of physical activity and the global impact of physical inactivity. The first series observing physical activity was released in 2012 ahead of the Summer Olympic Games. The study autho...
Source: Healthy Living - The Huffington Post - July 29, 2016 Category: Consumer Health News Source Type: news

EP 84. Motor control and learning strategy for efficient neurorehabilitation
Parkinson ’s, stroke, and other neurological diseases may significantly affect the control of voluntary, ballistic-like movements that normally are performed automatically and optimally as regards position accuracy, energy expenditure and movement execution time. The control functions (neural signals to mus cles) are to be re-learnt and re-optimised with respect to these performance indices. In our study, a natural approach for efficient motor learning in goal-directed motion tasks, incl. walking is proposed.
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: D. Despotova, P. Kiriazov Tags: ePoster Presentations – Free Topics Source Type: research

How to Maximize Your Yoga Calorie Burn
By Kristen Domonell for Life by Daily Burn Photo: Pond5 When considering a yoga class, the benefits of stress relief and stretching probably come to mind, more so than sweating and torching calories. But you can say Namaste to a serious heart-pumping workout with just a few tweaks to your flow. In fact, new research from the American College of Sports Medicine proves that sun salutations can count as your vigorous exercise for the week — as long as you push yourself through some powerful poses and add in a little strength training. Learn what actually counts as high-intensity exercise and why it's so important to ...
Source: Healthy Living - The Huffington Post - August 15, 2016 Category: Consumer Health News Source Type: news

A Perfect Match: health, Hippocrates and lifestyle medicine
Amid the frustration and despair associated with rising premiums, healthcare costs and obesity prevalence, is a trend that is slowly infiltrating the healthcare industry. Although some of the most notable trends (in fitness and nutrition) tend to come and go as quickly as a fastball (World Series, anyone?), this particular trend has an immense amount of staying power based on current scientific research. This immense power has little to do with pharmacological interventions and prescription refills and much more to do with our feet, forks, fingers and minds. This trend, as written in a recent article by the influential and...
Source: Healthy Living - The Huffington Post - November 3, 2016 Category: Consumer Health News Source Type: news

Cardiovascular Drift during Training for Fitness in Patients with Metabolic Syndrome
Purpose: The health benefits of a training program are largely influenced by the exercise dose and intensity. We sought to determine whether during a training bout of continuous versus interval exercise the workload needs to be reduced to maintain the prescribed target heart rate (HR). Methods: Fourteen obese (31 ± 4 kg·m−2) middle-age (57 ± 8 yr) individuals with metabolic syndrome, underwent two exercise training bouts matched by energy expenditure (i.e., 70 ± 5 min of continuous exercise [CE] or 45 min of interval exercise, high-intensity interval training [HIIT]). All subjects completed both trials in a randomiz...
Source: Medicine and Science in Sports and Exercise - February 18, 2017 Category: Sports Medicine Tags: Applied Sciences Source Type: research