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Smoking and drinking influence the advancing of ischemic stroke disease by targeting PTGS2 and TNFAIP3.
Authors: Miao Z, Guo M, Zhou S, Sun X, Wang F, Lu H, Cui Z Abstract In the present study, we explored the influence of cigarette smoking and alcohol drinking on gene expression level and related functions and pathways on the development of ischemic stroke (IS) disease. The gene expression profile of E-GEOD-22255 was obtained from 20 IS samples (7 patients without smoking or drinking history and 13 patients with smoking or drinking history) and 20 controls (9 normal controls without smoking or drinking history and 11 controls with smoking or drinking history). The correlation degree between gene expression and group...
Source: Experimental and Therapeutic Medicine - July 8, 2018 Category: General Medicine Tags: Exp Ther Med Source Type: research

AHA News: Flu Shot May Help Protect Vulnerable Hospital Patients From Heart Attack, Mini-Stroke
MONDAY, July 27, 2020 (American Heart Association News) -- Hospital patients at high risk for influenza had lower rates of death, heart attack, mini-stroke and cardiac arrest if they were vaccinated against flu during their hospital stay, a new...
Source: Drugs.com - Daily MedNews - July 27, 2020 Category: General Medicine Source Type: news

AHA News: Flu and COVID-19 Are Bad Enough, But They Also Can Raise Stroke Risk
WEDNESDAY, Oct. 14, 2020 (American Heart Association News) -- It ' s flu season. In the middle of a coronavirus pandemic. Is this any time to be thinking about your risk of stroke? Yes, researchers say. Having either influenza or the coronavirus seems...
Source: Drugs.com - Daily MedNews - October 14, 2020 Category: General Medicine Source Type: news

BA1 Bivalent COVID-19 Vaccine Use and Stroke in England
This study investigates the association between bivalent COVID-19 vaccines and ischemic stroke, as well as the effect of simultaneous influenza vaccination on the association.
Source: JAMA - Journal of the American Medical Association - June 15, 2023 Category: General Medicine Source Type: research

PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease.
CONCLUSIONS: The evidence for the clinical endpoint effects of  evolocumab and alirocumab were graded as high. There is a strong evidence base to prescribe PCSK9 monoclonal antibodies to people who might not be eligible for other lipid-lowering drugs, or to people who cannot meet their lipid goals on more traditional therapies, which was the main patient population of the available trials.  The evidence base of PCSK9 inhibitors compared with active treatment is much weaker (low very- to low-certainty evidence) and it is unclear whether evolocumab or alirocumab might be effectively used as replacement therapies. Related...
Source: Cochrane Database of Systematic Reviews - October 20, 2020 Category: General Medicine Authors: Schmidt AF, Carter JL, Pearce LS, Wilkins JT, Overington JP, Hingorani AD, Casas JP Tags: Cochrane Database Syst Rev Source Type: research

Age-dependent and sex-dependent differences in mortality from influenza-associated cardiovascular diseases among older adults in Shanghai, China: a population-based study
Conclusions Excess mortality rates for CVDs associated with influenza increased with age in older adults. The risk for influenza-associated IHD mortality was significantly higher in older women than men. Our findings will help implement targeted health strategies, including the promotion of influenza vaccination and early therapeutic intervention for the older population with CVD, to curb the influenza burden effectively.
Source: BMJ Open - September 19, 2022 Category: General Medicine Authors: Jin, S., Jiang, C., Xia, T., Gu, Z., Yu, H., Li, J., Zheng, Y., Pan, H., Qiao, J., Cai, R., Wu, H., Wang, C. Tags: Open access, Epidemiology Source Type: research

Effectiveness of the influenza vaccine in preventing admission to hospital and death in people with type 2 diabetes.
Authors: Vamos EP, Pape UJ, Curcin V, Harris MJ, Valabhji J, Majeed A, Millett C Abstract BACKGROUND: The health burden caused by seasonal influenza is substantial. We sought to examine the effectiveness of influenza vaccination against admission to hospital for acute cardiovascular and respiratory conditions and all-cause death in people with type 2 diabetes. METHODS: We conducted a retrospective cohort study using primary and secondary care data from the Clinical Practice Research Datalink in England, over a 7-year period between 2003/04 and 2009/10. We enrolled 124 503 adults with type 2 diabetes. Outcome me...
Source: Canadian Medical Association Journal - July 28, 2016 Category: Journals (General) Tags: CMAJ Source Type: research

Relationship between seasonal influenza rates and hospitalization and mortality rates due to acute cardiovascular diseases in a Spanish region.
CONCLUSIONS: The rates of hospitalisation and in-hospital mortality due to ACVD in the period 2001-2015 increased in relation to infection rates due to the influenza virus. PMID: 30738617 [PubMed - as supplied by publisher]
Source: Medicina Clinica - February 12, 2019 Category: General Medicine Tags: Med Clin (Barc) Source Type: research

Top medicine articles for April 2014
A collection of some interesting medical articles published recently:A Big Bet on Gluten-Free: 11% of households reporting purchases of gluten-free foods in 2013 (doubled in 3 yrs). 30% of the public says it would like to cut back on the amount of gluten it’s eating. "There is a growing population of people who have somehow heard that gluten-free is healthier or think of it as fashionable, and when they remove gluten from their diet, they’re inadvertently taking out a lot of processed foods and are really feeling the benefits of eating healthier foods.” http://buff.ly/1mt9phmNew nomenclature and classifications are p...
Source: Clinical Cases and Images - April 23, 2014 Category: Journals (General) Tags: Health News of the Day Source Type: news

Infant Deaths and Mortality from Gun Violence: Causal or Casual?
CONCLUSIONS: In NYC, non-Hispanic black IM declined significantly despite increasing income inequality and was strongly correlated with gun-related assault mortality and other major causes of death. These data are compatible with the hypothesis that activities related to overall population health, including those pertaining to gun-related homicide, may provide clues to reducing IM. Analytic epidemiological studies are needed to test these and other hypotheses formulated from these descriptive data. PMID: 29173931 [PubMed - in process]
Source: Journal of the National Medical Association - November 28, 2017 Category: General Medicine Tags: J Natl Med Assoc Source Type: research

Flu Can Have Dangerous Domino Effect on Older Adults
SUNDAY, Dec. 3, 2017 -- Even months after recovering from the flu, older people remain at increased risk for a heart attack, stroke or disability, a doctor who specializes in infectious diseases warns. " We all know about the illness influenza...
Source: Drugs.com - Daily MedNews - December 3, 2017 Category: General Medicine Source Type: news

Complications of influenza in 272 adult and pediatric patients in a  German university hospital during the seasonal epidemic 2017–2018
ConclusionPatients with influenza should be monitored for secondary pneumonia and myocardial infarction, and vaccination should be enforced especially in patients with coronary heart disease and cardiac insufficiency.
Source: Wiener Medizinische Wochenschrift - September 28, 2021 Category: General Medicine Source Type: research

COVID-19 vs Influenza for Risk of Thrombotic Events in Hospitalized Patients —Reply
In Reply We appreciate the interest in our recent study and the opportunity to share our responses to the comments by Dr Yii and colleagues. We sought to assess whether the risk of arterial and venous thromboembolism among patients hospitalized with COVID-19 differed from those hospitalized with another respiratory viral infection. Patients with influenza in 2018-2019 were selected as the comparator because this pathogen also causes pandemics, results in hospitalization when severe, and is associated with increased risk of acute myocardial infarction, ischemic stroke, and venous thromboembolism. Evaluating outcomes of COVI...
Source: JAMA - December 27, 2022 Category: General Medicine Source Type: research