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Report of cold agglutinins in a patient with acute ischemic stroke
Conclusion: We report here the first case of cerebral infarction probably due to the cold agglutinin disease. The underlying mechanism of cold agglutinins in the pathogenesis of acute ischemic stroke needs to be investigated further.
Source: BMC Neurology - October 30, 2015 Category: Neurology Authors: Haiqiang JinWei SunYongan SunYining HuangYunchuang Sun Source Type: research

Rituximab in treatment-resistant CIDP with antibodies against paranodal proteins
Conclusions: Rituximab treatment is an option for patients with CIDP with IgG4 anti-CNTN1/NF155 antibodies who are resistant to conventional therapies. Classification of evidence: This study provides Class IV evidence that rituximab is effective for patients with treatment-resistant CIDP with IgG4 anti-CNTN1 or anti-NF155 antibodies.
Source: Neurology Neuroimmunology and Neuroinflammation - September 3, 2015 Category: Neurology Authors: Querol, L., Rojas-Garcia, R., Diaz-Manera, J., Barcena, J., Pardo, J., Ortega-Moreno, A., Sedano, M. J., Sero-Ballesteros, L., Carvajal, A., Ortiz, N., Gallardo, E., Illa, I. Tags: Class IV, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research

P-006 evaluation of baseline ct aspects and admission neutrophil-lymphocyte ratio in perfusion-guided selected ica/mca stroke patients for endovascular reperfusion therapy
ConclusionsIn our cohort, baseline CT ASPECTS inversely correlated with admission NLR in anterior circulation AIS patients who had favorable perfusion imaging profile for IA reperfusion therapy. Additionally, in this subgroup of patients, NLR of 5 or less discriminated favorable from unfavorable ASPECTS.DisclosuresA. Honarmand: None. A. Shaibani: None. F. Syed: None. A. Elmokadem: None. M. Hurley: None. S. Ansari: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Honarmand, A., Shaibani, A., Syed, F., Elmokadem, A., Hurley, M., Ansari, S. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research

Refractory status epilepticus due to SMART syndrome
Conclusions Taking into account clinical evolution and ictal neuroimaging studies, status epilepticus could explain the origin of these episodes in SMART syndrome. Although most patients have reversible symptoms, in some cases, aggressive treatment to avoid sequelae is needed. This article is part of a Special Issue entitled “Status Epilepticus”.
Source: Epilepsy and Behavior - June 12, 2015 Category: Neurology Source Type: research

Refractory status epilepticus due to SMART syndrome.
CONCLUSIONS: Taking into account clinical evolution and ictal neuroimaging studies, status epilepticus could explain the origin of these episodes in SMART syndrome. Although most patients have reversible symptoms, in some cases, aggressive treatment to avoid sequelae is needed. This article is part of a Special Issue entitled "Status Epilepticus". PMID: 26071996 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - June 11, 2015 Category: Neurology Authors: Jaraba S, Puig O, Miró J, Velasco R, Castañer S, Rodríguez L, Izquierdo C, Simó M, Veciana M, Falip M Tags: Epilepsy Behav Source Type: research

Protective effects of corticosteroids in coronary artery bypass graft surgery alone or combined with valvular surgery: an updated and comprehensive meta-analysis and systematic review
This systematic review with meta-analysis sought to determine the protective effects of corticosteroids on clinical outcomes following coronary artery bypass grafting (CABG). Medline, Embase, Elsevier and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The effect sizes measured were odds ratio (OR) for categorical variables and weighted mean difference with 95% confidence interval (CI) for calculating differences between mean values of duration of hospitalization in intervention and control groups. Values of P < 0.1 for Q-test o...
Source: Interactive CardioVascular and Thoracic Surgery - May 28, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Ali-Hassan-Sayegh, S., Mirhosseini, S. J., Haddad, F., Karimi-bondarabadi, A. A., Shahidzadeh, A., Weymann, A., Popov, A.-F., Sabashnikov, A. Tags: Cardiac - pharmacology, Coronary disease Adult Cardiac Source Type: research

Clinical Outcomes of Metastatic Intra-cerebral Hemorrhage and Role of Acute Radiotherapy (P3.077)
CONCLUSIONS: Early recognition of metastatic disease as the etiology of ICH is important, particularly when it is the presenting manifestation. Despite the overall poor prognosis of metastatic cancer, early radiotherapy may increase survival and offer quality of life in selected group of patients. A larger case series is needed.Disclosure: Dr. Afzal has nothing to disclose. Dr. Mendoza has nothing to disclose. Dr. Latorre has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Afzal, U., Mendoza, M., Latorre, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhagic and Ischemic Stroke Source Type: research

Carotid plaque thickness is positively associated with decreased bone mineral density (P2.264)
CONCLUSIONS: This study showed that increased maximum carotid IMT/plaque value is significantly associated with decreased BMD after controlling for the effects of age, gender, and BMI in acute stroke patients. Study Supported by: NoneDisclosure: Dr. Han has nothing to disclose. Dr. Park has nothing to disclose. Dr. Park has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Han, S. W., Park, J. H., Park, J. H., Lee, J. Y., Lee, K.-Y. Tags: Cerebrovascular Disease and Interventional Neurology: Carotid Disease and IMT Source Type: research

Spinal Cord Infarction as the Initial Presentation of Systemic Lupus Erythematosus (P2.077)
CONCLUSIONS:Aggressive therapy with high dose corticosteroids and intravenous cyclophosphamide followed by oral therapy may be a successful therapeutic approach to spinal cord infarcts secondary to systemic lupus erythematosus. Study Supported by: N/ADisclosure: Dr. Michael has nothing to disclose. Dr. Hayat has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Michael, A., Hayat, G. Tags: Neurological Consequences of Autoimmune Disease Source Type: research

Disease activity in rheumatoid arthritis and the risk of cardiovascular events
Conclusions: Reduced time‐averaged disease activity in RA is associated with fewer CV events. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: D.H. Solomon, G Reed, J.M. Kremer, J.R. Curtis, M.E. Farkouh, L.R. Harrold, M.C. Hochberg, P Tsao, J Greenberg Tags: Full Length Source Type: research

Protective effects of corticosteroids in coronary artery bypass graft surgery alone or combined with valvular surgery: an updated and comprehensive meta-analysis and systematic review.
Abstract This systematic review with meta-analysis sought to determine the protective effects of corticosteroids on clinical outcomes following coronary artery bypass grafting (CABG). Medline, Embase, Elsevier and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The effect sizes measured were odds ratio (OR) for categorical variables and weighted mean difference with 95% confidence interval (CI) for calculating differences between mean values of duration of hospitalization in intervention and control groups. Values of P <...
Source: Hand Surgery - March 3, 2015 Category: Surgery Authors: Ali-Hassan-Sayegh S, Mirhosseini SJ, Haddad F, Karimi-Bondarabadi AA, Shahidzadeh A, Weymann A, Popov AF, Sabashnikov A Tags: Interact Cardiovasc Thorac Surg Source Type: research

Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement
Conclusion This study shows that MRI brain damage in SLE patients progresses independently from NP involvement as an effect of potentially modifiable risk factors and it is associated with increased risk of new NP events.
Source: Autoimmunity Reviews - January 27, 2015 Category: Allergy & Immunology Source Type: research

Aggressive Medical Care in Young Chinese Patients with Ischemic Stroke of Undetermined Etiology: A Retrospective Study
This study aimed to investigate the clinical and angiographic characteristics of ischemic stroke of undetermined etiology in young Chinese adults and to observe the effects of medication on their long-term outcomes. Methods: A total of 179 consecutive young patients with ischemic stroke of undetermined etiology were retrospectively analyzed for clinical and angiographic characteristics, laboratory tests, the choice of drug treatment, and follow-up outcomes. Any predictive power for recurrent stroke and new lesions or aggravated stenosis was analyzed. Results: 170 patients were clinically followed up for a median of 25 mont...
Source: Interventional Neurology - December 8, 2014 Category: Neurology Source Type: research

Incidence, risk factors, and outcomes of stroke post‐transplantation in patients receiving a steroid sparing immunosuppression protocol
This study has identified subgroups of patients who are at increased risk of CVA post‐transplant in patients otherwise receiving a steroid sparing immunosuppression protocol.
Source: Clinical Transplantation - November 19, 2014 Category: Transplant Surgery Authors: Michelle Willicombe, Nicola Kumar, Dawn Goodall, Candice Clarke, Adam G. McLean, Albert Power, David Taube Tags: Original Article Source Type: research

In search of a treatment for radiation-induced optic neuropathy
Opinion statement Radiation-induced optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss in one or both eyes within the months to years following radiation therapy. Posterior RON is a rare but devastating toxicity of radiation applied to the visual pathways to treat paranasal sinus and skull base tumors. Anterior RON is an unavoidable consequence of proton beam irradiation or ophthalmic plaque treatment of orbital, choroidal, or retinal tumors. Various treatments aimed at stabilizing and ideally reversing vision loss have been investigated but only in small cases serie...
Source: Current Treatment Options in Neurology - November 8, 2014 Category: Neurology Source Type: research

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