Protective effects of corticosteroids in coronary artery bypass graft surgery alone or combined with valvular surgery: an updated and comprehensive meta-analysis and systematic review

This systematic review with meta-analysis sought to determine the protective effects of corticosteroids on clinical outcomes following coronary artery bypass grafting (CABG). Medline, Embase, Elsevier and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The effect sizes measured were odds ratio (OR) for categorical variables and weighted mean difference with 95% confidence interval (CI) for calculating differences between mean values of duration of hospitalization in intervention and control groups. Values of P < 0.1 for Q-test or I2 > 50% indicated significant heterogeneity between the studies. The literature search of all major databases retrieved 3735 studies. After screening, a total of 45 trials were identified that reported outcomes. Pooled analysis was performed on incidence of atrial fibrillation (OR of 0.71; 95% CI: 0.59–0.86; P = 0.000), stroke (OR of 1.61; 95% CI: 0.63–4.1; P = 0.3), infection (OR of 1.03; 95% CI: 0.68–1.5; P = 0.8), re-infarction (OR of 0.88; 95% CI: 0.47–1.63; P = 0.6), length of ventilation time [weighted mean difference (WMD) of 0.257; 95% CI: 0.10–0.41; P = 0.00], length of hospital stay (WMD of –0.48; 95% CI: –0.66 to –0.3; P = 0.000), amount of blood loss (WMD of –124.05; 95% CI: –147.72 to –100.38; P = 0.00), re-exploration (OR of 1.25; 95% CI: 0.66–2.35; P = 0.4) and morta...
Source: Interactive CardioVascular and Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Cardiac - pharmacology, Coronary disease Adult Cardiac Source Type: research