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Effects of total saponins from Trillium tschonoskii rhizome on grey and white matter injury evaluated by quantitative multiparametric MRI in a rat model of ischemic stroke
Conclusion Our results suggested the potential protective and repair-promoting effects of TSTT on grey and white matter from damage induced by ischemia. This study provides a modern pharmacological basis for the application of TSTT in managing ischemic stroke. Graphical abstract
Source: Journal of Ethnopharmacology - January 12, 2018 Category: Drugs & Pharmacology Source Type: research

Thrombolysis in acute stroke without angiographically documented occlusion.
CONCLUSIONS: IAT using UK can be a safe and efficacious therapy for the treatment of acute ischemic stroke in patients without angiographic occlusion. Approximately 75% of these patients had a favorable clinical outcome and thrombolysis-related symptomatic hemorrhage was low. PMID: 28429356 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - April 22, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Stimulation of angiotensin II receptor 2 preserves cognitive function and is associated with an enhanced cerebral vascular density after stroke
In conclusion, C21 prevented cognitive impairment after stroke, likely through a mechanism involving vascular protection and restoration.PMID:34481068 | DOI:10.1016/j.vph.2021.106904
Source: Vascular Pharmacology - September 4, 2021 Category: Drugs & Pharmacology Authors: Wael Eldahshan Mohammed A Sayed Mohamed E Awad Heba A Ahmed Ellen Gillis Waleed Althomali Bindu Pillai Abdulkarim Alshammari Ladonya Jackson Guangkuo Dong Jennifer C Sullivan Marion A Cooley Mohammed Elsalanty Adviye Ergul Susan C Fagan Source Type: research

Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after thalamic hemorrhage: A case report.
Authors: Morinaga Y, Nii K, Sakamoto K, Inoue R, Mitsutake T, Hanada H Abstract Paroxysmal sympathetic hyperactivity (PSH) is a clinical condition characterized by abnormal paroxysmal surges in sympathetic nervous system activity. PSH is known to occur after severe head injury and hypoxic encephalopathy. Cases of PSH that develop after stroke have been reported worldwide; however, PSH is not commonly reported in the field of stroke research in Japan. Some studies have suggested that gabapentin may improve the symptoms of PSH. To our knowledge, this is the first case report demonstrating the efficacy of trazodone fo...
Source: Drug Discoveries and Therapeutics - July 23, 2019 Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research

Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient.
Abstract Cobb Syndrome (Spinal Arteriovenous Metameric Syndrome 1-31 (SAMS 1-31)) is a rare, non-hereditary disorder. Approximately 100 cases of CS have been described to date. The actual incidence may be much higher since only symptomatic patients were documented. In particular, post mortem studies suggest a possibly higher incidence of this syndrome. The main clinical manifestations of this syndrome include skin stains of vascular nature on the torso, in combination with spinal vascular malformations localized in one and the same metameric or spinal segment. A rare diagnosis of this syndrome in patients over 18 ...
Source: CNS and Neurological Disorders Drug Targets - February 17, 2021 Category: Drugs & Pharmacology Authors: Putilina M, Teplova N, Dvornikov A Tags: CNS Neurol Disord Drug Targets Source Type: research

Cutaneomeningospinal Angiomatosis (Cobb Syndrome) in a Young Patient
CNS Neurol Disord Drug Targets. 2021 Feb 17. doi: 10.2174/1871527320666210218083550. Online ahead of print.ABSTRACTCobb Syndrome (Spinal Arteriovenous Metameric Syndrome 1-31 (SAMS 1-31)) is a rare, non-hereditary disorder. Approximately 100 cases of CS have been described to date. The actual incidence may be much higher since only symptomatic patients were documented. In particular, post mortem studies suggest a possibly higher incidence of this syndrome. The main clinical manifestations of this syndrome include skin stains of vascular nature on the torso, in combination with spinal vascular malformations localized in one...
Source: CNS and Neurological Disorders Drug Targets - February 19, 2021 Category: Drugs & Pharmacology Authors: Marina Putilina Nataliya Teplova Anton Dvornikov Source Type: research

Epicardial Coronary Spasm in Women With Angina Pectoris and Unobstructed Coronary Arteries Is Linked With a Positive Family History: An Observational Study.
Abstract PURPOSE: Coronary spasm is frequently found in patients with angina and unobstructed coronaries. The pathophysiology is incompletely understood, although sex differences have been described. Often a positive family history (PFH) is encountered. We assessed the relationship between sex, coronary spasm, and a PFH for cardiovascular disease. METHODS: This single-center observational study recruited 415 stable angina patients with unobstructed coronaries (no stenosis >50%) between 2008 and 2011 (mean [SD] age, 62 [10] years; 38% men). Patients were referred for angiography because of signs and symptom...
Source: Clinical Therapeutics - August 16, 2018 Category: Drugs & Pharmacology Authors: Ong P, Pirozzolo G, Athanasiadis A, Sechtem U Tags: Clin Ther Source Type: research

Current Perspectives in Facilitated Angioplasty
Conclusions: With the current increased burden of acute coronary syndromes and the lack of immediate primary PCI facilities for all patients with STEMI, facilitated angioplasty seems a feasible therapeutic option. Another benefit of facilitated angioplasty may be represented by a major contribution of thrombolytic therapy in re-establishing microvascular myocardial blood flow.
Source: American Journal of Therapeutics - March 1, 2019 Category: Drugs & Pharmacology Tags: Systematic Reviews Source Type: research

Secondary Prevention Medical Therapy and Outcomes in Patients With Myocardial Infarction With Non-Obstructive Coronary Artery Disease
ConclusionThis prospective study suggests that RAAS inhibitor therapy provides mid-term beneficial effects on outcomes in MINOCA patients; in contrast, dual antiplatelet, β-blocker and statin therapy had no effects on mortality and MACE. These results should be considered preliminary and warrant confirmation from larger studies.
Source: Frontiers in Pharmacology - January 30, 2020 Category: Drugs & Pharmacology Source Type: research

A literature review of hypertensive retinopathy: systemic correlations and new technologies
CONCLUSIONS: The eye is the only organ in the human body where changes in the blood vessels due to systemic hypertension can be studied in vivo. All doctors should be familiar with this disease because it has been largely demonstrated that signs of HR are correlated to patient's health and mortality. Researchers should develop a new common, standardized, and objective method to assess hypertensive retinal changes; new technologies may have a significant role in this field. This review takes most of the literature published so far, including the OCTA studies in order to stimulate new points of reference to standardize param...
Source: Pharmacological Reviews - October 5, 2022 Category: Drugs & Pharmacology Authors: E Di Marco F Aiello M Lombardo M Di Marino F Missiroli R Mancino F Ricci C Nucci A Noce N Di Daniele M Cesareo Source Type: research

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