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Total 265 results found since Jan 2013.

Parenteral anticoagulation in ambulatory patients with cancer.
CONCLUSIONS: Heparin may have a small effect on mortality at 12 months and 24 months. It is associated with a reduction in venous thromboembolism and a likely increase in minor bleeding. Future research should further investigate the survival benefit of different types of anticoagulants in patients with different types and stages of cancer. The decision for a patient with cancer to start heparin therapy for survival benefit should balance the benefits and downsides, and should integrate the patient's values and preferences. PMID: 25491949 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - December 10, 2014 Category: Journals (General) Authors: Akl EA, Kahale LA, Ballout RA, Barba M, Yosuico VE, van Doormaal FF, Middeldorp S, Bryant A, Schünemann H Tags: Cochrane Database Syst Rev Source Type: research

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy.
CONCLUSION: More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs. PMID: 25559803 [PubMed - as supplied by publisher]
Source: Clinical Genitourinary Cancer - January 5, 2015 Category: Cancer & Oncology Authors: Koppelmans V, Vernooij MW, Boogerd W, Seynaeve C, Ikram MA, Breteler MM, Schagen SB Tags: J Clin Oncol Source Type: research

Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy Breast Cancer
Conclusion More CMBs were found in the aRCeBCS group than in the population-based controls. These vascular lesions potentially mark cerebrovascular frailty that could partially explain the well-documented association between chemotherapy and cognitive dysfunction. No support was found for a radiotherapy-related origin of CMBs.
Source: Journal of Clinical Oncology - February 18, 2015 Category: Cancer & Oncology Authors: Koppelmans, Vernooij, Boogerd, Seynaeve, Ikram, Breteler, Schagen Tags: Radiation, Chemotherapy Breast Cancer Source Type: research

Seizure reduction in a low-grade glioma: more than a beneficial side effect of temozolomide
Conclusions TMZ may contribute to an important reduction in seizure frequency in patients with LGG. Seizure reduction following TMZ treatment has prognostic significance and may serve as an important clinical outcome measure in patients with LGG.
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2015 Category: Neurosurgery Authors: Koekkoek, J. A. F., Dirven, L., Heimans, J. J., Postma, T. J., Vos, M. J., Reijneveld, J. C., Taphoorn, M. J. B. Tags: Epilepsy and seizures, Neurooncology, Stroke, CNS cancer Neuro-oncology Source Type: research

Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases
This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - April 3, 2015 Category: Molecular Biology Source Type: research

Effects of Acupuncture on Neuropathic Pain: A Systematic Review and Meta-analysis (P3.306)
CONCLUSIONS: The majority of trials demonstrate a positive effect of acupuncture over control condition in the treatment of neuropathy. Further more rigorously designed studies are needed to better characterize this effect.Disclosure: Dr. Dimitrova has nothing to disclose. Dr. Murchison has received research support from the National Institute for Neurological Disorders and Stroke. Dr. Oken has received personal compensation for activities with Dr. Willmar Schwabe Pharmaceuticals as a speaker.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Dimitrova, A., Murchison, C., Oken, B. Tags: Pain and Palliative Care Source Type: research

The effect of on body composition: A double blind randomized placebo-controlled trial among Iranian postmenopausal women
This study aimed to investigate whether Black cumin powder exerts beneficial effects on body composition among postmenopausal women. In this randomized, double blind, placebo controlled trial 61 menopausal women aged 45–65 years (at least one year after amenorrhea history) who living in Yasuj were recruited. They should not have history of induced menopause following chemotherapy, radiotherapy or surgery; diagnosed cancers; take hormones or anti hypertensive, antihyperlipidemic or diabetic drugs; history of uncontrolled hypertension, myocardial infarction, stroke or have undiagnosed malignancies.
Source: Maturitas - April 21, 2015 Category: Primary Care Authors: Saadat Parhizkar, Mehdi Akbartabar Toori, Esfandiar Afshoon Tags: P10 Source Type: research

Intraabdominal pressure, cardiac index and vascular resistance during hyperthermic intraperitoneal chemotherapy - a prospective observational study.
CONCLUSIONS: Increased intraabdominal pressure during HIPEC was comparable to pneumoperitoneum. Haemodynamic changes however were opposed with a decrease in SVRI and a compensative increase in CI. Current guidelines for anaesthetic management in patients undergoing HIPEC are mainly based on findings from laparoscopic surgery and should therefore be reconsidered critically. PMID: 25971283 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - May 16, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Subclinical Myocardial Impairment Occurred in Septal and Anterior LV Wall Segments After Anthracycline-Embedded Chemotherapy and did not Worsen During Adjuvant Trastuzumab Treatment in Breast Cancer Patients.
Abstract In a previous study of breast cancer patients, we found changes in cardiac function and size during the early stages of adjuvant trastuzumab (Herceptin(®)) therapy. Here we present a subgroup analysis of this patient cohort. This subgroup received a anthracycline-embedded chemotherapy followed by at least 3 months up to 6 months of adjuvant Herceptin(®) therapy. Twenty-seven female breast cancer patients with Her-2/-neu overexpression were studied using conventional echocardiography and 2D speckle tracking. These methods were done before anthracycline-embedded chemotherapy, before adjuvant trastuzumab...
Source: Cardiovascular Toxicology - May 29, 2015 Category: Cardiology Authors: Lange SA, Jung J, Jaeck A, Hitschold T, Ebner B Tags: Cardiovasc Toxicol Source Type: research

E-011 the key role of the blood-brain barrier in the endovascular treatment of brain tumors and how to by-pass it: new methods
ConclusionIA chemotherapy has been reported to be a promising new therapy; clinical studies are necessary to correlate this technique to the new ways of altering the BBB. Furthermore, these new methods could also be used in future scenarios before infusion of stem cells after stroke or brain trauma.DisclosuresS. Peschillo: 2; C; Penumbra. F. Diana: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Peschillo, S., Diana, F. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Dementia Risk in Irradiated Patients With Head and Neck Cancer
This study estimated the dementia risk associated with different treatment modalities in a head and neck cancer population with long-term follow-up. Taiwan's National Health Insurance claims database and a cancer registry database from the Collaboration Center of Health Information Application were linked for the present analysis. Patients with head and neck cancer, treated from January 1, 2002 to December 31, 2010, were included in the study. The follow-up duration was the period from the index date to December 31, 2012. Inclusion criteria were head and neck cancer; an age>20 years; and having undergone surgery, CT, concu...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Patient preference and decision-making for initiating metastatic colorectal cancer medical treatment
Conclusions Variations in patients’ willingness to tolerate different treatment-related adverse events underscore the need for improved communications between physicians and patients about the risks and benefits of their medical treatment, which helps make a more personalized decision for metastatic CRC treatment.
Source: Journal of Cancer Research and Clinical Oncology - November 18, 2015 Category: Cancer & Oncology Source Type: research

Patient preference and decision-making for initiating metastatic colorectal cancer medical treatment.
CONCLUSIONS: Variations in patients' willingness to tolerate different treatment-related adverse events underscore the need for improved communications between physicians and patients about the risks and benefits of their medical treatment, which helps make a more personalized decision for metastatic CRC treatment. PMID: 26577827 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - November 18, 2015 Category: Cancer & Oncology Authors: Fu AZ, Graves KD, Jensen RE, Marshall JL, Formoso M, Potosky AL Tags: J Cancer Res Clin Oncol Source Type: research

Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the tra...
Source: Trials - November 23, 2015 Category: Journals (General) Authors: Sylvain ChantepieJean-Baptiste MearLydia GuittetBenoît DervauxJean-Pierre MarolleauFabrice JardinJean-Jacques DutheilJean-Jacques ParientiJean-Pierre VilqueOumedaly Reman Source Type: research

Medical Research: The Best Investment We Can Make in Our Future
While the cure for cancer has been elusive, President Obama's National Cancer Moonshot initiative offers renewed hope that we could see breakthroughs in prevention, detection, and treatment for a disease that affects millions of Americans and their families. The cancer moonshot is the latest demonstration that Washington understands the potential for medical research to change lives and improve the health of all Americans. It builds on the bipartisan support we saw last fall when House and Senate negotiators agreed on a $2 billion budget increase for medical research through the National Institutes of Health (NIH). Today,...
Source: Science - The Huffington Post - February 18, 2016 Category: Science Source Type: news