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Total 3586 results found since Jan 2013.

NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway
Diabetes increases the risk of stroke, exacerbates neurological deficits, and increases mortality. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is a powerful neuroprotective factor that is also regarded as a metabolic regulator. The present study aimed to investigate the effect of nmFGF1 on the improvement of functional recovery in a mouse model of type 2 diabetic (T2D) stroke. We established a mouse model of T2D stroke by photothrombosis in mice that were fed a high-fat diet and injected with streptozotocin (STZ). We found that nmFGF1 reduced the size of the infarct and attenuated neurobehavioral deficits in our mous...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research

Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke
Biomed Pharmacother. 2022 May 20;151:113125. doi: 10.1016/j.biopha.2022.113125. Online ahead of print.ABSTRACTGlutamate-mediated excitotoxicity is an important mechanism leading to post ischemic stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most initially followed by ion transport protein dysfunction and disruption of ion homeostasis, which in turn leads to impaired glutamate release, reuptake, and excessive N-methyl-D-aspartate receptor (NMDAR) activation, promoting neuronal death. Despite extensive evidence from preclinical studies suggesting that excessive NMDAR stimulation during isc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 24, 2022 Category: Drugs & Pharmacology Authors: Zihuan Shen Mi Xiang Chen Chen Fan Ding Yuling Wang Chang Shang Laiyun Xin Yang Zhang Xiangning Cui Source Type: research

Detection of acute ischemic stroke and backtracking stroke onset time via machine learning analysis of metabolomics
Biomed Pharmacother. 2022 Sep 8;155:113641. doi: 10.1016/j.biopha.2022.113641. Online ahead of print.ABSTRACTThe time window from stroke onset is critical for the treatment decision. However, in unknown onset stroke, it is often difficult to determine the exact onset time because of the lack of assessment methods, which can result in controversial and random treatment decisions. Previous studies have shown that serum biomarkers, in addition to imaging assessment, are useful for determining the stroke onset time. However, as yet there are no specific biomarkers or corresponding methodologies that are accurate and effective ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2022 Category: Drugs & Pharmacology Authors: Yiheng Zhang Dayu Zhu Tao Li Xiaoya Wang Lili Zhao Xiaofei Yang Meijuan Dang Ye Li Yulun Wu Ziwei Lu Jialiang Lu Yating Jian Heying Wang Lei Zhang Xiaoyun Lu Ziyu Shen Hong Fan Wenshan Cai Guilian Zhang Source Type: research

Vital real-world experience regarding Naoshuantong capsules for unselected ischemic stroke (VENUS): Rationale, design, and baseline of a prospective, multicenter, observational study
Conclusion: The VENUS registry is designed to comprehensively document medical data regarding NC treatment for ischemic stroke in real-world settings. The findings of this study will provide valuable insights into the clinical management of patients with ischemic stroke and the subsequent outcomes of the use of NC when included in the best clinical practice.Study registration: This study was registered with the Chinese Clinical Trial Registry (URL: http://www.chictr.org.cn/index.aspx, Unique identifier: ChiCTR1900025053).
Source: Frontiers in Pharmacology - October 5, 2022 Category: Drugs & Pharmacology Source Type: research

Traditional Chinese medicine in treating ischemic stroke by modulating mitochondria: A comprehensive overview of experimental studies
Ischemic stroke has been a prominent focus of scientific investigation owing to its high prevalence, complex pathogenesis, and difficulties in treatment. Mitochondria play an important role in cellular energy homeostasis and are involved in neuronal death following ischemic stroke. Hence, maintaining mitochondrial function is critical for neuronal survival and neurological improvement in ischemic stroke, and mitochondria are key therapeutic targets in cerebral stroke research. With the benefits of high efficacy, low cost, and high safety, traditional Chinese medicine (TCM) has great advantages in preventing and treating is...
Source: Frontiers in Pharmacology - March 22, 2023 Category: Drugs & Pharmacology Source Type: research

The Role of Blood-Brain Barrier Transporters in Pathophysiology and Pharmacotherapy of Stroke.
Abstract Cerebral ischemia is one of the major causes of disability worldwide. In cerebral ischemic stroke, occlusion of a major cerebral artery by an embolus or local thrombosis can result in transient or permanent reduction of cerebral blood flow to a portion of the brain, resulting in deprivation of glucose and oxygen. Since the brain relies on a continuous supply of nutrients and ions via mostly carrier mediated processes across the blood-brain barrier (BBB), any irregularity in these transport mechanisms dramatically affects neuronal function and outcome after acute and chronic stroke. Despite numerous encour...
Source: Current Pharmaceutical Design - June 19, 2013 Category: Drugs & Pharmacology Authors: Shah K, Abbruscato T Tags: Curr Pharm Des Source Type: research

Venlafaxine treatment after endothelin-1-induced cortical stroke modulates growth factor expression and reduces tissue damage in rats.
Abstract Neuromodulators, such as antidepressants, may contribute to neuroprotection by modulating growth factor expression to exert anti-inflammatory effects and to support neuronal plasticity after stroke. Our objective was to study whether early treatment with venlafaxine, a serotonin-norepinephrine reuptake inhibitor, modulates growth factor expression and positively contributes to reducing the volume of infarcted brain tissue resulting in increased functional recovery. We studied the expression of BDNF, FGF2 and TGF-β1 by examining their mRNA and protein levels and cellular distribution using quantitative co...
Source: Neuropharmacology - March 7, 2016 Category: Drugs & Pharmacology Authors: Zepeda R, Contreras V, Pissani C, Stack K, Vargas M, Owen GI, Lazo OM, Bronfman FC Tags: Neuropharmacology Source Type: research

Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke.
This study evaluated the value of ALA as adjunctive therapy for stroke recovery by comparing whether oral or intravenous supplementation of ALA best support recovery from ischemia. Motor and cognitive deficits were assessed using rotarod, pole and Morris water maze tests. ALA supplementation in diet was better than intravenous treatment in improving motor coordination, but this improvement was not due to a neuroprotective effect since infarct size was not reduced. Both types of ALA supplementation improved spatial learning and memory after stroke. This cognitive improvement correlated with higher survival of hippocampal ne...
Source: Neuropharmacology - April 27, 2016 Category: Drugs & Pharmacology Authors: Bourourou M, Heurteaux C, Blondeau N Tags: Neuropharmacology Source Type: research

Stroke in a Young Woman as a Presenting Manifestation of Membranous Nephropathy
Stroke is one of the most severe complications of nephrotic syndrome (NS), only a few cases have been reported in previous literature. Some of those cases are not clear about whether the stroke was purely caused by NS because they also had other risk factors for stroke, such as old age, hypertension. A recent study showed that serum albumin less than 2.8 g/dL is a risk factor for thromboembolic events (venous thromboembolic events). Anticoagulation is suggested for patients with NS with low albumin by KIDIGO guideline 2012. Here, we describe a case in which a young patient presented with stroke as an initial symptom of mem...
Source: American Journal of Therapeutics - May 1, 2016 Category: Drugs & Pharmacology Tags: Case Reports Source Type: research

Atrial fibrillation burden and atrial fibrillation type: Clinical significance and impact on the risk of stroke and decision making for long-term anticoagulation.
Abstract Atrial fibrillation (AF) is a common arrhythmia increasing the risk of morbidity and adverse outcomes (stroke, heart failure, death). AF is found in 1-2% of the general population, with increasing prevalence with aging. Its exact epidemiological profile is incomplete and underestimated, because 10-40% of AF patients (particularly the elderly) can be asymptomatic ("clinically silent or subclinical AF"), with occasional electrocardiographic diagnosis. The research interest on silent AF has increased by the evidence that its outcome is no less severe, in terms of risks of stroke and death, than that for symp...
Source: Vascular Pharmacology - May 15, 2016 Category: Drugs & Pharmacology Authors: Boriani G, Pettorelli D Tags: Vascul Pharmacol Source Type: research

Effect of Chinese herbal medicine on stroke patients with type 2 diabetes
Conclusion The use of CHM as adjunctive therapy may improve the overall survival (OS) of stroke patients with T2D. The list of the comprehensive herbal medicines that they used might be useful in future large-scale, randomized clinical investigations of agent effectiveness, safety, and potential interactions with conventional treatments in stroke patients with T2D. Graphical abstract
Source: Journal of Ethnopharmacology - February 19, 2017 Category: Drugs & Pharmacology Source Type: research

Clinical study on anti-epileptic drug with B vitamins for the treatment of epilepsy after stroke.
CONCLUSIONS: Anti-epilepsy drugs combined with B vitamins can improve epilepsy control after stroke and reduce new stroke occurrence. This effect may be associated with stability of plasma ADMA levels. Vitamin B12 may be better than vitamin B complex in the treatment of epilepsy after stroke. PMID: 28770947 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - August 6, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Advances in stroke pharmacology
Publication date: Available online 25 May 2018 Source:Pharmacology & Therapeutics Author(s): Zhenhua Zhou, Jianfei Lu, Wen-Wu Liu, Anatol Manaenko, Xianhua Hou, Qiyong Mei, Jun-Long Huang, Jiping Tang, John H. Zhang, Honghong Yao, Qin Hu Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause of death and adult disability worldwide. Various pharmacological agents have been developed for the treatment of stroke either through interrupting the molecular pathways leading to neuronal death or enhancing neuronal survival and regeneration. Except for rtPA, few of these agents have su...
Source: Pharmacology and Therapeutics - May 26, 2018 Category: Drugs & Pharmacology Source Type: research

Colchicine for Stroke Prevention: A Systematic Review and Meta-Analysis.
Abstract PURPOSE: There has been recent interest in the role of colchicine in cardiovascular diseases, given the implication of inflammation in the pathogenesis of atherothrombosis. This systematic review assessed the role of colchicine in preventing primary or secondary stroke/transient ischemic attack (TIA) in an adult population. METHODS: Four databases were electronically searched: MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), and OpenGrey. Studies were eligible if they reported stroke or TIA incidence as a primary/secondary end point, or as an adverse event. Only case-control...
Source: Clinical Therapeutics - February 27, 2019 Category: Drugs & Pharmacology Authors: Khandkar C, Vaidya K, Patel S Tags: Clin Ther Source Type: research