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Total 265 results found since Jan 2013.

Exercise 'most proven method' to prevent return of breast cancer
Conclusion This was a helpful summary of recent research into how lifestyle changes impact on the risk of breast cancer returning, but it does have some limitations. Researching lifestyle factors separately is always difficult as they tend to clump together, making it difficult to pick apart individual factors. For example, people who are more physically active tend to have a healthier diet and are less likely to drink excessive amounts of alcohol or smoke. While the researchers say many studies attempt to make adjustments for these confounding factors, it is difficult to know which studies did this and how successful they...
Source: NHS News Feed - February 22, 2017 Category: Consumer Health News Tags: Cancer QA articles Lifestyle/exercise Source Type: news

Predictors of venous thromboembolism recurrence and the bleeding events identified using a Japanese healthcare database.
CONCLUSIONS: These findings obtained from healthcare database suggest predictors either for recurrent VTE and bleeding that should be considered when selecting treatment to reduce the risk of recurrent VTE and mitigate bleeding. PMID: 28245956 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - February 24, 2017 Category: Cardiology Authors: Nakamura M, Yamada N, Oda E, Matsubayashi D, Ota K, Kobayashi M, Matsushita Y, Kaburagi J, Ibusuki K, Takita A, Iwashita M, Yamaguchi T Tags: J Cardiol Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Intra-arterial chemotherapy for retinoblastoma: Two-year results from tertiary eye-care center in India
Conclusions: IAC is an effective therapy for globe preservation in eyes with intraocular RB, in the setting of a developing country like India. Larger studies with longer follow-up are required to validate these results.
Source: Indian Journal of Ophthalmology - May 17, 2017 Category: Opthalmology Authors: Pukhraj Rishi Tarun Sharma Minal Sharma Aditya Maitray Abhinav Dhami Vishvesh Aggarwal Saravanan Munusamy R Ravikumar Satheesh Ramamurthy Source Type: research

MassDevice.com +5 | The top 5 medtech stories for May 19, 2017
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. The key components of a well-designed wearable: Sense, analyze, act One of the earliest uses of a wearable technology was recorded during Emperor Nero’s rule over the Roman Empire from 54 to 68 AD. A brutal leader, the empero...
Source: Mass Device - May 19, 2017 Category: Medical Devices Authors: MassDevice Tags: News Well Plus 5 Source Type: news

The Global End-Diastolic Volume (GEDV) Could Be More Appropiate to Fluid Management Than Central Venous Pressure (CVP) During Closed Hyperthermic Intrabdominal Chemotherapy with CO2 Circulation.
CONCLUSIONS: Closed intrabdominal chemotherapy with CO2 circulation model may be a safe model for HIPEC by means of a gas exchanger. GEDV and its changes significantly correlated to CI, and not observed for CVP. GEDV values may be more appropriate for monitoring cardiac preload, blood loss limitation and to predict changes in intravascular volume status during intraperitoneal chemotherapy. PMID: 28557569 [PubMed - as supplied by publisher]
Source: Journal of Investigative Surgery - June 1, 2017 Category: Surgery Tags: J Invest Surg Source Type: research

Change in pulmonary function and cardiorespiratory fitness following chemotherapy in testicular cancer patients - a pilot study
Conclusions: There was a substantial reduction in VO2max after BEP corresponding to three decades of physiological aging. This reduction may reflect a decrease in the patients’ cardiac function and oxygen carrying capacity, and not to reduced DLco.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Edvardsen, E., Larsen, K.-O., Fossa, S. D., Ikdahl, T., Loge, J. H., Thorsen, L. Tags: Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

New-Onset Cardiovascular Morbidity in Older Adults With Stage I to III Colorectal Cancer.
Conclusion Older patients with colorectal cancer are at increased risk of developing CVD and CHF. Diabetes and hypertension interact with chemotherapy to increase the risk of cardiovascular morbidity. Future studies should assess the potential for personalized therapeutic options for those with preexisting morbidities and for structured monitoring for patients with a history of exposure to chemotherapy regimens, as well as explore the management of preexisting comorbidities to address long-term cardiovascular morbidity. PMID: 29337636 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - January 16, 2018 Category: Cancer & Oncology Authors: Kenzik KM, Balentine C, Richman J, Kilgore M, Bhatia S, Williams GR Tags: J Clin Oncol Source Type: research

New Insights from Studies of Clonal Hematopoiesis.
Abstract Clonal hematopoiesis (CH) describes an asymptomatic expansion of blood cells descended from a single hematopoietic stem cell. Recent studies have shown that CH increases in frequency with aging, and is often driven by somatic mutations in genes that are recurrently mutated in hematologic malignancies. When CH is associated with a mutation in a leukemia-associated gene at a variant allele frequency of 0.02 or greater, it is termed "clonal hematopoiesis of indeterminate potential" (CHIP).  CHIP has a 0.5-1% risk per year of progression to hematological neoplasia, and increases both all-cause mortality and ...
Source: Clinical Cancer Research - April 27, 2018 Category: Cancer & Oncology Authors: Gibson CJ, Steensma DP Tags: Clin Cancer Res Source Type: research

Changes in Hepatic Blood Flow and Liver Function during Closed Abdominal Hyperthermic Intraperitoneal Chemotherapy following Cytoreduction Surgery.
Conclusion: Despite optimizing intravenous fluids during closed abdominal HIPEC, we observed a marked decrease in HBF and liver function. Both effects were transient and limited to the period of HIPEC but could influence the choice between closed or open abdominal cavity procedure for HIPEC and should be considered in similar clinical situations of increased IAP. PMID: 29721013 [PubMed]
Source: Gastroenterology Research and Practice - May 4, 2018 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Cardiac output response to exercise in patients before allogenic hematopoietic stem cell transplantation
ConclusionThese findings suggest that cardiac output response to exercise indicates exercise intolerance, which may not be detected by 6MD in patients before HSCT.
Source: International Journal of Clinical Oncology - July 5, 2018 Category: Cancer & Oncology Source Type: research

Outcomes of Takotsubo cardiomyopathy in hospitalized cancer patients
ConclusionsOutcomes are significantly worse in patients with TCM and malignancy. Hence, this patient population must be regarded as high-risk and early diagnostic consideration for TCM is warranted. Early intervention may help lower mortality, decrease resource utilization and reduce the health care costs in these patients.
Source: Journal of Cancer Research and Clinical Oncology - July 13, 2018 Category: Cancer & Oncology Source Type: research

The prognostic value of Red cell distribution width(RDW) in acute pulmonary thromboembolism
Conclusion: High RDW level is associated with higher 30 and 90 days mortality rate in acute PT patients. This marker could be considered as a valuable prognostic factor in acute PE.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Parsa, S., Hosseinvand, N., Peiman, S. Tags: Pulmonary embolism Source Type: research

Medical Conditions Among Survivors of Adolescent and Young Adult Non-Hodgkin Lymphoma (NHL), Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)
Conclusion: This study found that sociodemographic factors were associated with the risk of developing medical conditions in AYA NHL, ALL and AML survivors. As expected, the risk of medical conditions varied by cancer type and treatment, with those undergoing SCT having a higher risk of medical conditions regardless of cancer type. NHL and ALL survivors who were uninsured or publicly insured were at a consistently higher risk of developing medical conditions, as were Hispanic ALL survivors and Black AML survivors. Our findings highlight the higher burden of medical conditions in subgroups of cancer survivors that may relat...
Source: Blood - November 21, 2018 Category: Hematology Authors: Keegan, T. H. M., Muffly, L. S., Li, Q., Alvarez, E., Brunson, A. M., Malogolowkin, M., Wun, T. Tags: 904. Outcomes Research-Malignant Conditions: Real World Outcomes Source Type: research

Acute Neurotoxicity during ALL Therapy Is Associated with Treatment Intensity, Age and Female Sex - an Analysis of SAE Reports from the UKALL 2003 Trial
Discussion:This large study identifies treatment intensity as the main risk factor for developing acute neurotoxicity with female sex, age and CNS status having a significant modifying effect. CNS status may reflect increased intrathecal therapy given to non-CNS-1 patients. Females are more vulnerable to cranial radiotherapy induced neurotoxicity but this is the first report of female sex as a risk factor on contemporary chemotherapy treatment protocols. Reassuringly, the occurrence of acute neurotoxicity did not influence survival rates. These data provide an important benchmark for ongoing international deep phenotyping ...
Source: Blood - November 21, 2018 Category: Hematology Authors: Wahid, Q.-u.-A., Hamadeh, L., McGowan, S., Hough, R., Vora, A., Moorman, A. V., Halsey, C. Tags: 612. Acute Lymphoblastic Leukemia: Clinical Studies: Poster I Source Type: research