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Exploring heterogeneities of cardiovascular efficacy and effectiveness of SGLT2 inhibitors in patients with type 2 diabetes: an umbrella review of evidence from randomized clinical trials versus real-world observational studies
ConclusionOS presented significant benefits of SGLT2 inhibitors both on primary and secondary preventions of MACE, MI, stroke, ACM, CVM, and HHF; RCTs did not. Given the spectrum of T2D patient characteristics and the strength of overall evidence, our review underscored the importance of constant integration of all available information and critical interpretation of all inconsistencies to optimize evidence-based diabetes care.
Source: European Journal of Clinical Pharmacology - July 27, 2022 Category: Drugs & Pharmacology Source Type: research
Grading of Japanese Diet Intakes by 24-Hour Urine Analysis of Taurine and Soy Isoflavones in Relation to Cardiovascular Risks
In conclusion, the higher the J score, which corresponds to Japanese dietary habits, the lower the BMI and cholesterol levels, as well as mortality rate from coronary heart disease, but the higher the average life expectancy among the Japanese. However, these higher J scorings were associated with high-salt intake and high Na/K ratios; therefore, they contributed to high blood pressure and high mortality rate caused by stroke in Japan. These results indicate that low-salt intake should be recommended to the Japanese who are consuming seafood and soy regularly in order to maintain lower blood pressure and to extend healthy ...
Source: Advances in Experimental Medicine and Biology - July 26, 2022 Category: Research Authors: Mari Mori Miki Sagara Hideki Mori Yukio Yamori Source Type: research
People With Diabetes Are More Vulnerable to Heart Disease. How to Reduce the Risk
If you’ve been diagnosed with diabetes, know that you’ve got plenty of company. The American Diabetes Association (ADA) reports that in 2019, the most recent year for which data is available, 37.3 million adults in the U.S.—about 11.3% of the population—had the chronic condition, and that number continues to grow.
Type 1 diabetes develops when the body isn’t able to produce insulin, and Type 2 occurs when the body doesn’t use insulin correctly. Type 2 is the most common form of diabetes, and when it’s uncontrolled, a person’s blood sugar can jump to dangerous levels that requ...
Source: TIME: Health - July 20, 2022 Category: Consumer Health News Authors: Elaine K. Howley Tags: Uncategorized Disease freelance healthscienceclimate Source Type: news
How Heat Waves Could Have Long-Term Impacts on Your Health
Health officials from the U.S., the U.K., Europe, and Japan have been warning residents to stay out of the sun as the northern hemisphere experiences some of the highest early summer temperatures ever recorded. It’s not just to prevent heat-stroke, but to prevent the long-term consequences as well. As climate change drives summer temperatures even higher than usual, medical researchers are starting to find links between sustained heat exposure and chronic health conditions ranging from diabetes to kidney stones, cardiovascular disease and even obesity. “While increased risk for heat stroke is an obvious manifes...
Source: TIME: Health - July 13, 2022 Category: Consumer Health News Authors: Aryn Baker Tags: Uncategorized climate change Climate Is Everything Evergreen healthscienceclimate Londontime overnight Source Type: news
GLP1RA versus SGLT2i tended to have more favorable ischemic outcomes including stroke?
In Kim and colleagues' article [1] reporting a retrospective cohort study aiming to assess the cardiorenal benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) versus glucagon-like peptide-1 receptor agonists (GLP1RA) in patients with type 2 diabetes mellitus (T2DM), one main conclusion is that GLP1RA tended to have more favorable ischemic outcomes. To some extent, this conclusion is exaggerated because GLP1RA and SGLT2i had the similar risks of coronary revascularization and stroke according to the main results of this article.
Source: International Journal of Cardiology - July 12, 2022 Category: Cardiology Authors: Lixin Du, Yu Zhang, Pan Wang, Zhigang Li, Yunhui Zhao, Jianpeng Yuan Tags: Letter to the Editor Source Type: research
Determination of 23 related analytes in bone marrow fluid and hippocampus of C57BL/6 mice on cerebral ischemia-reperfusion injury by HPLC-FLD
Biomed Chromatogr. 2022 Jun 28:e5435. doi: 10.1002/bmc.5435. Online ahead of print.ABSTRACTThe study of brain diseases has long been of interest to researchers worldwide, and stroke is the third leading cause of death that threatens human health. At the same time, a cerebral ischemia-reperfusion injury is closely associated with high rates of disability and mortality. The conditions of the 6-Aminoquinolyl N-hydroxysccinimidyl carbamate (AQC) method for the derivatization of amino acids in the bone marrow fluid and hippocampus of C57BL/6 mice with cerebral ischemia/reperfusion injury were explored and optimized, such as the...
Source: Biomedical Chromatography : BMC - June 28, 2022 Category: Biomedical Science Authors: Jing Zhang Junqing Yang Ying Luo Jiansha Li Tao Gong Suqiong Huang Yan Xiong Xinhui Jiang Source Type: research
New Therapeutic Options for Type 2 Diabetes Mellitus and Their Impact Against Ischemic Heart Disease
Type 2 diabetes mellitus (T2DM) greatly increases risk for cardiovascular disease, including ischemic heart disease and myocardial infarction. With the completion of several cardiovascular outcomes trials (CVOTs) for new glucose-lowering therapies, including the sodium-glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 receptor (GLP-1R) agonists, we now have strong evidence alluding to the cardioprotective nature of these agents in people with T2DM. These agents have frequently been observed to reduce rates for 3-point major adverse cardiovascular events, which encompass death from cardiovascular causes...
Source: Frontiers in Physiology - June 27, 2022 Category: Physiology Source Type: research
Impaired renal function and mortalities in acute heart failure with different phenotypes
ConclusionsOn-admission IRF was independently predictive of long-term mortality in patients hospitalized for HF, irrespective of HF phenotypes. Furthermore, IRF was also associated with short-term mortality in HFrEF and HFmrEF, but not in HFpEF.
Source: ESC Heart Failure - June 17, 2022 Category: Cardiology Authors: Wei ‐Ming Huang,
Hao‐Chih Chang,
Ching‐Wei Lee,
Chi‐Jung Huang,
Wen‐Chung Yu,
Hao‐Min Cheng,
Chao‐Yu Guo,
Chern‐En Chiang,
Chen‐Huan Chen,
Shih‐Hsien Sung Tags: Original Article Source Type: research
Predictive role of modifiable factors in stroke: an umbrella review
Discussion
Diet with rich macronutrients and micronutrients, healthy dietary patterns and favourable physical, emotional health and environmental management should be promoted to decrease the burden of stroke.
PROSPERO registration number
CRD42021249921.
Source: BMJ Open - June 16, 2022 Category: General Medicine Authors: Wang, X., Liang, M., Zeng, F., Wang, Y., Yang, Y., Nie, F., Shang, M., Ta, N., Wen, L., Ou, L., Yang, Z., Liu, W. Tags: Open access, Neurology Source Type: research
Exploring heterogeneities of cardiovascular efficacy and effectiveness of SGLT2 inhibitors in patients with type 2 diabetes: an umbrella review of evidence from randomized clinical trials versus real-world observational studies
ConclusionOS presented significant benefits of SGLT2 inhibitors both on primary and secondary preventions of MACE, MI, stroke, ACM, CVM, and HHF; RCTs did not. Given the spectrum of T2D patient characteristics and the strength of overall evidence, our review underscored the importance of constant integration of all available information and critical interpretation of all inconsistencies to optimize evidence-based diabetes care.
Source: European Journal of Clinical Pharmacology - June 7, 2022 Category: Drugs & Pharmacology Source Type: research
Treatment of diabetes mellitus has borne much fruit in the prevention of cardiovascular disease
ABSTRACTCardiovascular (CV) disease is the most alarming complication of diabetes mellitus (DM), and a strategy aiming at CV event prevention in DM has long been debated. Large landmark clinical trials have shown CV benefits of intensive glycemic control as a “legacy effect” in newly diagnosed type 2 DM (T2DM). In contrast, we have learned that excessive intervention aimed at strong glycemic control could cause unexpected CV death in patients who are resistant to treatments against hyperglycemia. It has also been shown that the comprehensive multifac torial intervention for CV risk factors that was advocated in the cur...
Source: Journal of Diabetes Investigation - May 31, 2022 Category: Endocrinology Authors: Hiroaki Yagyu,
Hitoshi Shimano Tags: REVIEW ARTICLE Source Type: research
Predictive Capability of Metabolic Panels for Postoperative Atrial Fibrillation in Cardiac Surgery Patients
Postoperative atrial fibrillation (POAF) occurs in up to 65% of cardiac surgery patients and is associated with an increased risk for stroke and mortality. Electrolyte disturbances in sodium (Na+), potassium (K+), total calcium (Ca2+), chloride (Cl −), and magnesium (Mg2+) are predisposing factors for POAF, but these imbalances are yet to be used to predict POAF. The purpose of this study is to determine whether the development of POAF can be predicted by blood plasma ionic composition.
Source: Journal of Surgical Research - May 26, 2022 Category: Surgery Authors: Steve S. Qian, Ian Crandell, Alexandra Hanlon, Mark Joseph, Steven Poelzing Tags: Cardiac Surgery Source Type: research
New Data From Two Large Studies Reinforce Effectiveness of Dual Pathway Inhibition (DPI) with XARELTO ® (rivaroxaban) Plus Aspirin in Patients with Coronary Artery Disease (CAD) and/or Peripheral Artery Disease (PAD)
RARITAN, N.J., May 23, 2022 – Findings from the XARELTO® (rivaroxaban) Phase 3 COMPASS Long-Term Open Label Extension (LTOLE) study and the XARELTO® in Combination with Acetylsalicylic Acid (XATOA) registry have been published in the European Society of Cardiology’s (ESC) European Heart Journal, Cardiovascular Pharmacotherapy. Additionally, the XATOA registry was presented at the American Congress of Cardiology’s 71st Annual Scientific Session (ACC.22). These studies provide further evidence supporting the role of dual pathway inhibition (DPI) with the XARELTO® vascular dose (2.5 mg twice daily plus aspirin 100 mg...
Source: Johnson and Johnson - May 23, 2022 Category: Pharmaceuticals Source Type: news
