Filtered By:
Education: Study
Nutrition: Iron

This page shows you your search results in order of relevance. This is page number 8.

Order by Relevance | Date

Total 290 results found since Jan 2013.

Associations between Ambient Fine Particulate Oxidative Potential and Cardiorespiratory Emergency Department Visits
Conclusions: Lag 0–2 OPDTT was associated with ED visits for multiple cardiorespiratory outcomes, providing support for the utility of OPDTT as a measure of fine particle toxicity. https://doi.org/10.1289/EHP1545 Received: 23 December 2016 Revised: 4 August 2017 Accepted: 12 August 2017 Published: 26 October 2017 Please address correspondence to J.Y. Abrams, Centers for Disease Control and Prevention, NCEZID/DHCPP, 1600 Clifton Rd. NE, CDC Mailstop A30, Atlanta, GA 30333 USA. Telephone: (404) 639-5121. Email: jabrams@cdc.gov Supplemental Material is available online (https://doi.org/10.1289/EHP1545). The authors ...
Source: EHP Research - October 26, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Publication date: 5 October 2017 Source:Cell, Volume 171, Issue 2 Author(s): Brent R. Stockwell, José Pedro Friedmann Angeli, Hülya Bayir, Ashley I. Bush, Marcus Conrad, Scott J. Dixon, Simone Fulda, Sergio Gascón, Stavroula K. Hatzios, Valerian E. Kagan, Kay Noel, Xuejun Jiang, Andreas Linkermann, Maureen E. Murphy, Michael Overholtzer, Atsushi Oyagi, Gabriela C. Pagnussat, Jason Park, Qitao Ran, Craig S. Rosenfeld, Konstantin Salnikow, Daolin Tang, Frank M. Torti, Suzy V. Torti, Shinya Toyokuni, K.A. Woerpel, Donna D. Zhang Ferroptosis is a form of regulated cell death characterized by the iron-dependent accumulation...
Source: Cell - October 29, 2017 Category: Cytology Source Type: research

Degree of anemia, indirect markers of hemolysis, and vascular complications of sickle cell disease in Africa
In conclusion, severe anemia at steady state in SCD patients living in West and Central Africa is associated with elevated TRV, microalbuminuria, and leg ulcers, but these vascular complications are not independently associated with indirect markers of increased hemolysis. Other mechanisms leading to anemia, including malnutrition and infectious diseases, may also play a role in the development of SCD vasculopathy.
Source: Blood - November 16, 2017 Category: Hematology Authors: Dubert, M., Elion, J., Tolo, A., Diallo, D. A., Diop, S., Diagne, I., Sanogo, I., Belinga, S., Guifo, O., Wamba, G., Ngo Sack, F., Boidy, K., Kamara, I., Traore, Y., Diakite, C. O., Gbonon, V., Faye, B. F., Seck, M., Deme Ly, I., Chelo, D., NGuetta, R., D Tags: Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis Source Type: research

Prevalence and Natural History of Superficial Siderosis Clinical Sciences
This study aimed to report the prevalence and natural history of SS in a population-based study.Methods—Brain magnetic resonance imaging scans from the MCSA (Mayo Clinic Study of Aging), a population-based study of residents 50 to 89 years of age in Olmsted County, Minnesota, were reviewed. Participants with imaging consistent with SS were identified from 2011 through 2016. An inverse probability weighting approach was used to convert our observed frequencies to population prevalence of SS. Additional data abstracted included amyloid positron emission tomography, Apolipoprotein E genotype, coexisting cerebral microbleeds...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Michael Pichler, Prashanthi Vemuri, Alejandro A. Rabinstein, Jeremiah Aakre, Kelly D. Flemming, Robert D. Brown Jr, Neeraj Kumar, Kejal Kantarci, Walter Kremers, Michelle M. Mielke, David S. Knopman, Clifford R. Jack Jr, Ronald C. Petersen, Val Lowe, Jona Tags: Magnetic Resonance Imaging (MRI), Cerebrovascular Malformations, Intracranial Hemorrhage Original Contributions Source Type: research

InspireMD touts 2-year CGuard EPS results
InspireMD (NYSE:NSPR) this week released two-year results from the Paradigm 101 clinical study of its CGuard embolic protection system. Results from the trial were initially presented at the 2017 VEITH Symposium in New York last month. In the investigator-led study, researchers examined the use of the CGuard EPS system in 101 patients with symptomatic or high-risk asymptomatic carotid artery stenosis. Data from the study indicated that there were no deaths, major stroke or myocardial infarctions as a result of periprocedural or postprocedural interventions at at two years. InspireMD said that the results were consistent w...
Source: Mass Device - December 6, 2017 Category: Medical Devices Authors: Fink Densford Tags: Clinical Trials Neurological InspireMD Source Type: news

Urine Arsenic and Arsenic Metabolites in U.S. Adults and Biomarkers of Inflammation, Oxidative Stress, and Endothelial Dysfunction: A Cross-Sectional Study
Conclusion: In a cross-sectional study of U.S. adults, we observed some positive associations of uAs and toenail As concentrations with biomarkers potentially relevant to CVD pathogenesis and inflammation, and evidence of a higher capacity to metabolize inorganic As was negatively associated with a marker of oxidative stress. https://doi.org/10.1289/EHP2062 Received: 14 April 2017 Revised: 13 November 2017 Accepted: 15 November 2017 Published: 15 December 2017 Address correspondence to S.F. Farzan, 2001 N. Soto St., Los Angeles, CA, 90032. Telephone: (323)-442-5101; Email: sffarzan@usc.edu Supplemental Material is ava...
Source: EHP Research - December 16, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Carotid Atheroma From Men Has Significantly Higher Levels of Inflammation and Iron Metabolism Enabled by Macrophages Clinical Sciences
Conclusions—Male patients with carotid atheroma had more advanced and ruptured lesions associated with significantly higher levels of inflammatory macrophage infiltration and high iron stores in the blood and in their plaques. These findings help to understand sex differences and iron metabolism in atherosclerosis and factors related to atheroma progression.
Source: Stroke - January 22, 2018 Category: Neurology Authors: Xi-Ming Yuan, Liam J. Ward, Claes Forssell, Nabeel Siraj, Wei Li Tags: Inflammation, Oxidant Stress, Pathophysiology, Proteomics, Atherosclerosis Original Contributions Source Type: research

Minocycline Effects on Intracerebral Hemorrhage-Induced Iron Overload in Aged Rats Basic Sciences
This study quantified brain iron levels after ICH with magnetic resonance imaging R2* mapping. The effect of minocycline on iron overload and ICH-induced brain injury in aged rats was also determined.Methods—Aged (18 months old) male Fischer 344 rats had an intracerebral injection of autologous blood or saline, and brain iron levels were measured by magnetic resonance imaging R2* mapping. Some ICH rats were treated with minocycline or vehicle. The rats were euthanized at days 7 and 28 after ICH, and brains were used for immunohistochemistry and Western blot analyses. Magnetic resonance imaging (T2-weighted, T2* gradient-...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Shenglong Cao, Ya Hua, Richard F. Keep, Neeraj Chaudhary, Guohua Xi Tags: Basic Science Research, Intracranial Hemorrhage Original Contributions Source Type: research

Automated RBC exchange compared to manual exchange transfusion for children with sickle cell disease is cost-effective and reduces iron overload.
CONCLUSION: Erythrocytapheresis reduces iron overload and allows a longer interval between procedures without a higher RBC requirement from the second year on aRBX. The cost did not increase as estimated in our Belgian Health Care System. PMID: 29574950 [PubMed - as supplied by publisher]
Source: Transfusion - March 25, 2018 Category: Hematology Authors: Dedeken L, Lê PQ, Rozen L, El Kenz H, Huybrechts S, Devalck C, Diallo S, Heijmans C, Ferster A Tags: Transfusion Source Type: research

Beneficial Role of Neutrophils Through Function of Lactoferrin After Intracerebral Hemorrhage Basic Sciences
Conclusions—LTF delivered to the ICH-affected brain by infiltrating PMNs may assist in hematoma detoxification and represent a powerful potential target for the treatment of ICH.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Xiurong Zhao, Shun–Ming Ting, Guanghua Sun, Meaghan Roy–O’Reilly, Alexis S. Mobley, Jesus Bautista Garrido, Xueping Zheng, Lidiya Obertas, Joo Eun Jung, Marian Kruzel, Jaroslaw Aronowski Tags: Translational Studies Original Contributions Source Type: research

Imaging vulnerable plaques by targeting inflammation in atherosclerosis using fluorescent-labeled dual-ligand microparticles of iron oxide and magnetic resonance imaging
This study characterized inflammation in atherosclerosis using dual-targeted microparticles of iron oxide (DT-MPIO) as a magnetic resonance imaging (MRI) probe.
Source: Journal of Vascular Surgery - June 23, 2017 Category: Surgery Authors: Joyce M.S. Chan, Claudia Monaco, Marzena Wylezinska-Arridge, Jordi L. Tremoleda, Jennifer E. Cole, Michael Goddard, Maggie S.H. Cheung, Kishore K. Bhakoo, Richard G.J. Gibbs Tags: From bench to bedside Source Type: research

Minocycline attenuates brain injury and iron overload after intracerebral hemorrhage in aged female rats.
Abstract Brain iron overload is involved in brain injury after intracerebral hemorrhage (ICH). There is evidence that systemic administration of minocycline reduces brain iron level and improves neurological outcome in experimental models of hemorrhagic and ischemic stroke. However, there is evidence in cerebral ischemia that minocycline is not protective in aged female animals. Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at different time points (1 to 28 days) in aged (18-month old) female Fischer 344 rat ICH model and to investig...
Source: Neurobiology of Disease - June 4, 2018 Category: Neurology Authors: Dai S, Hua Y, Keep RF, Novakovic N, Fei Z, Xi G Tags: Neurobiol Dis Source Type: research

Edaravone Reduces Iron-Mediated Hydrocephalus and Behavioral Disorder in Rat by Activating the Nrf2/HO-1 Pathway
Our previous studies have demonstrated that hemorrhage-derived iron has a key role in causing brain injury after intraventricular hemorrhage (IVH). Based on this finding, we hypothesized that edaravone, a free-radical scavenger, has the potential to alleviate hydrocephalus and neurological deficits post-IVH by suppressing iron-induced oxidative stress. Thus, this study aimed to investigate the efficacy of edaravone for rats with FeCl3 injection, as well as to explore the related molecular mechanism.
Source: Journal of Stroke and Cerebrovascular Diseases - September 8, 2018 Category: Neurology Authors: Jianbo Zhang, Xia Shi, Zhi Chen, Junjun Geng, Yuelong Wang, Hua Feng, Gang Zhu, Qianwei Chen Source Type: research

Brain Ceruloplasmin Expression After Experimental Intracerebral Hemorrhage and Protection Against Iron-Induced Brain Injury
This study had two parts: first, rats had injection of autologous blood into the right basal ganglia and the time course of CP expression in the brain examined (protein and mRNA). Second, rats had an injection of either Fe2+ in saline, Fe2+ plus CP in saline, or saline alone into the right basal ganglia. All rats in the second part had T2-weighted magnetic resonance imaging, and behavioral tests before the brains were harvested for immunohistochemistry and Western blotting. We found that CP was expressed on neurons and astrocytes in both cortex and basal ganglia after ICH. The time course showed that ICH induced CP express...
Source: Translational Stroke Research - October 12, 2018 Category: Neurology Source Type: research

Predictive value of iron parameters in neurocritically ill patients
ConclusionsSerum ferritin level at admission could be used as an independent predictor of short ‐term mortality and long‐term functional outcome in neurocritically ill patients with eGFR ≥ 60 ml/min/1.73 m2.
Source: Brain and Behavior - November 19, 2018 Category: Neurology Authors: Ling Xie, Yu Peng, Kaibin Huang, Yongming Wu, Shengnan Wang Tags: ORIGINAL RESEARCH Source Type: research