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Total 55 results found since Jan 2013.

Carotid Intervention Improves Cognitive Function in Patients With Severe Atherosclerotic Carotid Disease
Conclusions: This prospective study showed that carotid intervention improved memory and executive function in patients with the severe carotid occlusive disease. It highlights the cognitive benefit of the carotid intervention in appropriately selected patients.
Source: Annals of Surgery - August 18, 2022 Category: Surgery Tags: Papers of the 141st ASA Annual Meeting Source Type: research

Eliminating Medication Copayments for Low-income Older Adults at High Cardiovascular Risk: A Randomized Controlled Trial
Conclusions: In low-income adults at high cardiovascular risk, eliminating copayments (average $35 a month) did not improve clinical outcomes or reduce healthcare costs, despite a modest improvement in adherence to medications.PMID:36871215 | DOI:10.1161/CIRCULATIONAHA.123.064188
Source: Circulation - March 5, 2023 Category: Cardiology Authors: David J T Campbell Chad Mitchell Brenda R Hemmelgarn Marcello Tonelli Peter Faris Jianguo Zhang Ross T Tsuyuki Jane Fletcher Flora Au Scott Klarenbach Derek V Exner Braden J Manns Interdisciplinary Chronic Disease Collaboration Source Type: research

Safety and Effect of Very Low Levels of Low-Density Lipoprotein Cholesterol on Cardiovascular Events
In conclusion, clinical trial evidence demonstrating the efficacy and safety of LDL cholesterol lowering to a very low level is essential to ascertain the benefits and risks in reducing the residual risk of vascular disease.
Source: The American Journal of Cardiology - February 1, 2013 Category: Cardiology Authors: John C. LaRosa, Terje R. Pedersen, Ransi Somaratne, Scott M. Wasserman Tags: Review Source Type: research

Cardiovascular Risk Factors and Events in Pancreas-Kidney Transplants
Abstract: Cardiovascular and cerebrovascular disease (CCVD) are major causes of morbidity and mortality among patients with diabetes. Strict control of treatable risk factors that contribute to atherosclerosis is important to reduce the risk of stroke, myocardial infarction, and peripheral arterial disease. Simultaneous pancreas-kidney transplantation (SPKT) may significantly improve these risk factors in patients with type 1 diabetes. We studied 103 SPKT from our center with both organs functioning for metabolic and hypertensive control; body mass index (BMI); immunosuppression; and CCVD events. The 53 females/50 males s...
Source: Transplantation Proceedings - April 1, 2013 Category: Transplant Surgery Authors: L. Martins, I. Fonseca, L. Dias, J. Malheiro, A. Rocha, P. Azevedo, H. Silva, R. Almeida, A.C. Henriques, J. Davide, A. Cabrita Tags: Renal Transplantation Source Type: research

Effectiveness of combined therapy with angiotensin-converting enzyme inhibitors and statins in reducing mortality in diabetic patients with critical limb ischemia: An observational study
Conclusions: In patients with diabetes and CLI mortality after two years is high. Life expectancy was better in patients receiving combined therapy with ACE and statin but not with therapy with only a statin or an ACE.
Source: Diabetes Research and Clinical Practice - February 3, 2014 Category: Endocrinology Authors: Ezio Faglia, Giacomo Clerici, Alessia Scatena, Maurizio Caminiti, Vincenzo Curci, Alberto Morabito, Vincenzo Prisco, Rosaria Greco, Mike Edmonds Tags: Clinical Care and Education Source Type: research

Cholesterol, Statins and the Risk of Dementia in the Oldest-Old: The 90+ Study (S58.003)
CONCLUSIONS: Contrary to studies reporting that high cholesterol is associated with decreased dementia in the oldest-old, we report that hypercholesterolemia was not associated with dementia while statin users were at decreased dementia risk. There are a variety of mechanisms by which statins may be neuroprotective including effects on amyloid production, neurofibrillary tangles, secondary stroke prevention, and other anti-inflammatory pleiotropic effects. Additional research is needed to explore other potential explanations for our results along with assessment of the effect of serum cholesterol levels and statin lipophil...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Evans, M., Kawas, C., Corrada, M. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Clinical Aspects Source Type: research

Improving cardiovascular disease using managed networks in general practice: an observational study in inner London.
CONCLUSION: Managed geographical practice networks delivered a step-change in key CVD performance indicators in comparison with England, London, or similar PCT/CCGs. PMID: 24771840 [PubMed - in process]
Source: The British Journal of General Practice - May 1, 2014 Category: Primary Care Authors: Robson J, Hull S, Mathur R, Boomla K Tags: Br J Gen Pract Source Type: research

The Growing Gap in Hypertension Control Between Insured and Uninsured Adults: National Health and Nutrition Examination Survey 1988 to 2010 Epidemiology/Population
Hypertension awareness, treatment, and control are lower among uninsured than insured adults. Time trends in differences and underlying modifiable factors are important for informing strategies to improve health equity. National Health and Nutrition Examination Surveys 1988 to 1994, 1999 to 2004, and 2005 to 2010 data in adults aged 18 to 64 years were analyzed to explore this opportunity. The proportion of adults with hypertension who were uninsured increased from 12.3% in 1988 to 1994 to 17.4% in 2005 to 2010. In 1988 to 1994, hypertension awareness, treatment, and control to <140/<90 mm Hg (30.1% versus 26.5%; P=0...
Source: Hypertension - October 8, 2014 Category: Cardiology Authors: Egan, B. M., Li, J., Small, J., Nietert, P. J., Sinopoli, A. Tags: Cerebrovascular disease/stroke Epidemiology/Population Source Type: research

Informed shared decision-making programme on the prevention of myocardial infarction in type 2 diabetes: a randomised controlled trial
Conclusions The ISDM-P on preventive measures in type 2 diabetes was effective under high fidelity conditions. Involvement of diabetes educators may facilitate implementation of the informed shared decision-making. Trial registration number ISRCTN84636255.
Source: BMJ Open - November 13, 2015 Category: Journals (General) Authors: Buhse, S., Mühlhauser, I., Heller, T., Kuniss, N., Müller, U. A., Kasper, J., Lehmann, T., Lenz, M. Tags: Open access, Evidence based practice, Medical education and training Research Source Type: research

Current 10-year atherosclerotic cardiovascular disease risk threshold for statin eligibility is cost-effective for primary prevention
Commentary on: Pandya A, Sy S, Cho S, et al. Cost effectiveness of 10-year risk thresholds for initiation of statin therapy for primary prevention of cardiovascular disease. JAMA 2015;314: 142–50 . Context The American College of Cardiology American Heart Association (ACC/AHA) cholesterol guidelines replaced the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) in 2013,1 a change that was accompanied by significant controversy.2 Notable among the criticisms was that the pooled cohort equations (PCE) overestimates risk and coupled with the relatively lenient risk threshold (10-year PCE &g...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Yeboah, J. Tags: Health policy, Epidemiologic studies, Drugs: cardiovascular system, Neuromuscular disease, Stroke, Ischaemic heart disease, Musculoskeletal syndromes, Health economics, Health service research Economic analysis Source Type: research

Statin Use, Incident Dementia and Alzheimer Disease in Elderly African Americans.
CONCLUSIONS: Consistent use of statin medications during eight years of follow-up resulted in significantly reduced risk for incident AD and a trend toward reduced risk for incident dementia. PMID: 26673814 [PubMed - in process]
Source: Ethnicity and Disease - December 19, 2015 Category: Global & Universal Tags: Ethn Dis Source Type: research

Effects of Stenting for Atherosclerotic Renal Artery Stenosis on eGFR and Predictors of Clinical Events in the CORAL Trial.
CONCLUSIONS: Stenting did not influence eGFR in participants with atherosclerotic renal artery stenosis receiving renin-angiotensin system inhibition-based therapy. Predictors of clinical events were traditional risk factors for CKD and cardiovascular disease. PMID: 27225988 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - May 24, 2016 Category: Urology & Nephrology Authors: Tuttle KR, Dworkin LD, Henrich W, Greco BA, Steffes M, Tobe S, Shapiro JI, Jamerson K, Lyass A, Pencina K, Massaro JM, D'Agostino RB, Cutlip DE, Murphy TP, Cooper CJ Tags: Clin J Am Soc Nephrol Source Type: research

A cost-effectiveness analysis of over-the-counter statins.
CONCLUSIONS: With proper labeling and consumer education, it is highly likely that OTC statins would be cost-effective, as they significantly improve population health without large increases in healthcare costs. PMID: 27266585 [PubMed - in process]
Source: The American Journal of Managed Care - June 10, 2016 Category: Health Management Authors: Stomberg C, Albaugh M, Shiffman S, Sood N Tags: Am J Manag Care Source Type: research

Impact of the 2013 American College of Cardiology/American Heart Association cholesterol guidelines on the prescription of high-intensity statins in patients hospitalized for acute coronary syndrome or stroke
Conclusions Physicians were more likely to prescribe high-intensity statins in statin-naïve patients as compared with intensifying existing statin therapy, and their prescription pattern was lower after CVA vs ACS.
Source: American Heart Journal - September 17, 2016 Category: Cardiology Source Type: research