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Total 1266 results found since Jan 2013.

In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice
CONCLUSIONS: Our study demonstrated that IX prevents obesity and enhances glucose metabolism by inhibiting dietary fat absorption. This mechanism is linked to suppressing pancreatic lipase activity and shifts in microbial composition, notably an increase in A. muciniphila. These highlight new treatment strategies for preventing metabolic syndrome by boosting the gut microbiota with food components.PMID:37709134 | DOI:10.1016/j.molmet.2023.101797
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Yoshiyuki Watanabe Shiho Fujisaka Yoshitomo Morinaga Shiro Watanabe Allah Nawaz Hideki Hatta Tomonobu Kado Ayumi Nishimura Muhammad Bilal Muhammad Rahil Aslam Keiko Honda Yoshimi Nakagawa Samir Softic Kenichi Hirabayashi Takashi Nakagawa Yoshinori Nagai K Source Type: research

Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research

RNA binding protein IGF2BP1 synergizes with ETV6-RUNX1 to drive oncogenic signaling in B-cell Acute Lymphoblastic Leukemia
CONCLUSION: Our data suggest a combined impact of the ETV6::RUNX1 fusion protein and RNA binding protein, IGF2BP1 in activating multiple oncogenic pathways in B-ALL which makes IGF2BP1 and these pathways as attractive therapeutic targets and biomarkers.PMID:37670323 | DOI:10.1186/s13046-023-02810-1
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Gunjan Sharma Tiffany M Tran Ishu Bansal Mohammad Sabique Beg Ruchi Bhardwaj Jaspal Bassi Yuande Tan Amit Kumar Jaiswal Christine Tso Ayushi Jain Jay Singh Parthaprasad Chattopadhyay Archna Singh Anita Chopra Sameer Bakhshi David Casero Dinesh S Rao Jayan Source Type: research

Beta-cell death and dysfunction drives hyperglycaemia in organ donors
CONCLUSIONS: In pancreas donors, hyperglycaemia requiring IT is strongly associated with beta-cell death. This provides an explanation for the relationship of donor IT with post-transplant beta-cell dysfunction in transplant recipients.PMID:37646197 | DOI:10.1111/dom.15248
Source: Cancer Control - August 30, 2023 Category: Cancer & Oncology Authors: Iestyn M Shapey Angela Summers James O'Sullivan Catherine Fullwood Neil A Hanley John Casey Shareen Forbes Miranda Rosenthal Paul R V Johnson Pratik Choudhary James Bushnell James A M Shaw Daniel Neiman Ruth Shemer Benjamin Glaser Yuval Dor Titus Augustin Source Type: research

Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential
CONCLUSIONS: Our findings suggest that the FGF2-immobilized matrix can support initial cell adhesion, maturation, and glucose-stimulated insulin secretion within the host microenvironment. Such a cell culture platform can offer novel strategies to obtain functional pancreatic β-cells from patient-specific cell sources, ultimately enabling better treatment for diabetes mellitus.PMID:37644502 | DOI:10.1186/s40824-023-00419-1
Source: Cell Research - August 29, 2023 Category: Cytology Authors: Ji Hoon Jeong Ki Nam Park Joo Hyun Kim KyungMu Noh Sung Sik Hur Yunhye Kim Moonju Hong Jun Chul Chung Jae Hong Park Jongsoon Lee Young-Ik Son Ju Hun Lee Sang-Heon Kim Yongsung Hwang Source Type: research

Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cardiorenal Biomarkers, Canagliflozin, and Outcomes in Diabetic Kidney Disease: The CREDENCE Trial
CONCLUSIONS: Multiple cardiorenal stress biomarkers are strongly prognostic in people with type 2 diabetes and albuminuria. Canagliflozin modestly reduced the longitudinal trajectory of rise in each biomarker. Change in the biomarker level in addition to the baseline level augments the primary outcome prediction.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT02065791.PMID:37603600 | DOI:10.1161/CIRCULATIONAHA.123.065251
Source: Circulation - August 21, 2023 Category: Cardiology Authors: James L Januzzi Reza Mohebi Yuxi Liu Naveed Sattar Hiddo J L Heerspink Eshetu Tefera Muthiah Vaduganathan Javed Butler Yshai Yavin Jingwei Li Carol A Pollock Vlado Perkovic Bruce Neal Michael K Hansen Source Type: research

Insulin: know what your immunoassay detects. Evaluation of two new immunoassays
CONCLUSION: An accurate biological interpretation of insulinemia relies on knowledge of the specificity of the immunoassay used.PMID:37598742 | DOI:10.1016/j.cca.2023.117516
Source: International Journal of Clinical Chemistry - August 20, 2023 Category: Chemistry Authors: Alizee Violin Emmanuel Enard Justine Blin Dimitri Paillusson Antoine Collin David Gu énet V éronique Raverot Kalyane Bach-Ngohou Damien Masson Source Type: research

Diabetes in stiff-person syndrome
Trends Endocrinol Metab. 2023 Aug 14:S1043-2760(23)00148-0. doi: 10.1016/j.tem.2023.07.005. Online ahead of print.ABSTRACTAnti-glutamic acid decarboxylase (GAD) autoantibodies are a hallmark of stiff-person syndrome (SPS) and insulin-dependent diabetes mellitus (IDDM). However, patients with concurrent IDDM and SPS often manifest insulin resistance, and SPS-associated IDDM probably has heterogeneous causes. Some patients manifest IDDM associated only with high titers of anti-GAD65 caused by SPS. By contrast, other patients develop IDDM only after being treated with high-dose corticosteroids or they progress to insulin depe...
Source: Trends in Endocrinology and Metabolism: TEM - August 16, 2023 Category: Endocrinology Authors: Petr Heneberg Source Type: research