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Drug: Insulin
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Total 61154 results found since Jan 2013.
Study of the Impact of PROximity Support for Patients With Type 1 DIABetes Treated With an Insulin Pump or Closed Loop.
Condition: Diabetes Mellitus, Type 1 Intervention: Other: enhanced care model provided by Timkl, a home support provider Sponsors: timkl; Sanoia Recruiting
Source: ClinicalTrials.gov - September 22, 2023 Category: Research Source Type: clinical trials
Adipocyte glucocorticoid receptor inhibits immune regulatory genes to maintain immune cell homeostasis in adipose tissue
Endocrinology. 2023 Sep 20:bqad143. doi: 10.1210/endocr/bqad143. Online ahead of print.ABSTRACTGlucocorticoids acting via the glucocorticoid receptors (GR) are key regulators of metabolism and the stress response. However, uncontrolled or excessive GR signaling adversely affects adipose tissue, including endocrine, immune, and metabolic functions. Inflammation of the adipose tissue promotes systemic metabolic dysfunction; however, the molecular mechanisms underlying the role of adipocyte GR in regulating genes associated with adipose tissue inflammation are poorly understood. We performed in vivo studies using adipocyte sp...
Source: Endocrinology - September 22, 2023 Category: Endocrinology Authors: Shripa Amatya Dylan Tietje-Mckinney Schaefer Mueller Maria G Petrillo Matthew D Woolard Sushma Bharrhan A Wayne Orr Christopher G Kevil John A Cidlowski Diana Cruz-Topete Source Type: research
Effects of < em > Aeriscardovia aeriphila < /em > on growth performance, antioxidant functions, immune responses, and gut microbiota in broiler chickens
In conclusion, oral administration of A. aeriphila could improve the growth performance, serum antioxidant capacity, immune modulation, and gut health of broilers. Our findings may provide important information for the application of A. aeriphila in poultry production.PMID:37735944 | DOI:10.1631/jzus.B2200621
Source: J Zhejiang Univ Sci ... - September 22, 2023 Category: Science Authors: Muhammad Zahid Farooq Xinkai Wang Xianghua Yan Source Type: research
Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
J Orthop Surg Res. 2023 Sep 22;18(1):713. doi: 10.1186/s13018-023-04119-3.ABSTRACTOsteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytok...
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Source Type: research
Practice of complementary and alternative medicine use in North Indian children with type 1 diabetes: an exploratory study
ConclusionCAM, mostly herbal, is frequently used among children with T1DM in North India and has detrimental effects on glycemic control. This information should be used during diabetes education to avoid medical emergencies related to sub-optimal insulin dosing.
Source: Diabetology International - September 22, 2023 Category: Endocrinology Source Type: research
Defective insulin-stimulated equilibrative nucleoside transporter-2 activity and altered subcellular transporter distribution drive the loss of adenosine homeostasis in diabetic kidney disease progression
CONCLUSION: Deficient insulin regulation of ENT2 activity contributes to chronically high adenosine levels and glomerular alterations that underline diabetic kidney disease progression.PMID:37734469 | DOI:10.1016/j.bbadis.2023.166890
Source: Biochimica et Biophysica Acta - September 21, 2023 Category: Biochemistry Authors: Raibel Suarez Carolina Villarreal Yessica Nahuelp án Claudia Jara Carlos Oyarz ún Sebasti án Alarcón Montserrat M D íaz-Encarnación Elena Guill én-Gómez Claudia Quezada Rody San Mart ín Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
Temporal optimization of exercise to lower fasting glucose levels
This study examined the effect of exercise timing on evening and overnight glucose concentrations in individuals who were non-obese with normal fasting glucose levels (Non-Ob; n = 18) and individuals with obesity (OB) with impaired fasting glucose levels (OB+IFG) and without (n = 16 and n = 18, respectively). Subjects were studied on three occasions (no exercise (NOEX)), morning exercise (AMEX; 0700 h) and evening exercise (PMEX; 2000 h). The evening meal was provided (1800 h) and blood samples were taken from 1740 to 0700 h and morning endogenous glucose production (EGP) was measured. Glucose and insulin concentrations in...
Source: The Journal of Physiology - September 21, 2023 Category: Physiology Authors: Jill A Kanaley J W Porter N C Winn G Lastra A Chockalingam R J Pettit-Mee G F Petroski C Cobelli M Schiavon E J Parks Source Type: research
A population-based study on hyperinsulinaemia and arterial stiffness in men with and without abdominal aortic aneurysm
CONCLUSION: In this population-based study hyperinsulinaemia as a marker of insulin resistance, but not hyperglycaemia or aortic stiffness, was associated with AAA and abdominal aortic diameter in 65-year-old men.PMID:37731907 | PMC:PMC10508446 | DOI:10.1097/XCE.0000000000000290
Source: Atherosclerosis - September 21, 2023 Category: Cardiology Authors: Shahab Fatemi Stefan Acosta Moncef Zarrouk Peter M Nilsson Anders Gotts äter Source Type: research
D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans
In this study, we intended to explore the anti-aging mechanism of DP, utilizing computer modeling techniques. The results demonstrated that DP significantly delayed H2O2-induced cellular senescence. Model PC12 cells treated with DP exhibited increased cell viability, increased antioxidant enzyme activity (SOD, CAT), and reduced ROS and MDA levels. Furthermore, DP was discovered to have a positive effect on healthy longevity. In C. elegans, DP treatment enhanced lifespan, stress capacity, antioxidant capacity (T-SOD/CAT/GSH-Px/MDA/ROS), and altered aging-related indicators of lipofuscin accumulation, pharyngeal pump rate, m...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 21, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research
Brown adipocyte mineralocorticoid receptor deficiency impairs metabolic regulation in diet-induced obese mice
J Lipid Res. 2023 Sep 19:100449. doi: 10.1016/j.jlr.2023.100449. Online ahead of print.ABSTRACTActivation of brown adipose tissue (BAT) contributes to energy dissipation and metabolic health. Although mineralocorticoid receptor (MR) antagonists have been demonstrated to improve metabolism under obesity, the underlying mechanisms remain incompletely understood. We aimed to evaluate the role of BAT MR in metabolic regulation. After 8 weeks of high fat diet (HFD) feeding, BAT MR knockout (BMRKO) mice manifested significantly increased body weight, fat mass, serum fasting glucose and impaired glucose homeostasis compared to li...
Source: Cell Research - September 21, 2023 Category: Cytology Authors: Chu-Mao Chen Xiao-Qian Meng Hong Zhu Ting Liu Yuan Liu Lu-Jun Zhou Guo-Dong Zhu Xiao-Bei Chen Xu-Guang Guo Sheng-Zhong Duan Source Type: research
How Could Digital Technology Make An Impact On Primary Care?
I truly hope that very soon I do not have to make an appointment at the GP when I suspect signs of a disease, but my GP will send me a message that she spotted something irregular in my latest test results and my digital health data, so I’d better visit. Let me show you in detail how primary care should be carried out in the future!
Digital health should become an organic part of primary care in the future
I live a fairly healthy life. I use data to improve my lifestyle and to make better decisions by optimising my sleep pattern, my physical, my cognitive or my emotional abilities; and I had several genetic tests....
Source: The Medical Futurist - September 21, 2023 Category: Information Technology Authors: berci.mesko Tags: Digital Health Research Healthcare Innovation technology wearables GP primary care general practitioner Source Type: blogs
South Africa: Aspen's Covid Vaccine Facility in Gqeberha Switches to Making Insulin for Africa
[Daily Maverick] Aspen South Africa will soon deliver millions of vials of human insulin to patients in Africa at a low cost after reaching an agreement with Novo Nordisk.
Source: AllAfrica News: Health and Medicine - September 21, 2023 Category: African Health Tags: Coronavirus Health and Medicine South Africa Southern Africa Source Type: news
The role of autophagy in the treatment of type II diabetes and its complications: a review
Type II diabetes mellitus (T2DM) is a chronic metabolic disease characterized by prolonged hyperglycemia and insulin resistance (IR). Its incidence is increasing annually, posing a significant threat to human life and health. Consequently, there is an urgent requirement to discover effective drugs and investigate the pathogenesis of T2DM. Autophagy plays a crucial role in maintaining normal islet structure. However, in a state of high glucose, autophagy is inhibited, resulting in impaired islet function, insulin resistance, and complications. Studies have shown that modulating autophagy through activation or inhibition can...
Source: Frontiers in Endocrinology - September 21, 2023 Category: Endocrinology Source Type: research
