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Drug: Polyethylene Glycol
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Total 15 results found since Jan 2013.
Ultrasound-mediated multifunctional magnetic microbubbles for drug delivery of celastrol in VX2 liver transplant tumors
Drug Deliv Transl Res. 2023 Aug 28. doi: 10.1007/s13346-023-01421-9. Online ahead of print.ABSTRACTCelastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and systemic toxicity. Ferric oxide (Fe3O4) has a large specific surface area and can be functionalized by inorganic modification to form complex magnetic drug delivery systems. Herein, Fe3O4 was surface-modified with citric acid and polyethylene glycol (PEG) (via) the Mitsunobu reaction and then covalently bound to CST. Finally, magnetic microbubbles (MMBs) containing perfluoropropane ...
Source: Cell Research - August 28, 2023 Category: Cytology Authors: Jian Huang Zhengji Wang Zihe Chen Chunxin Huang Ying Wang Xing Li Weiyang Lv Guiqiang Qi Huilin Liu Source Type: research
Molecular Imaging of Matrix Metalloproteinase-2 in Atherosclerosis Using a Smart Multifunctional PET/MRI Nanoparticle
CONCLUSION: Using a combination of innovative imaging modalities, in this study, we demonstrate the feasibility of applying the novel smart MMP2cNPs as a PET/MR hybrid imaging contrast agent for detection of MMP-2 in atherosclerotic plaque in vivo.PMID:36600879 | PMC:PMC9805955 | DOI:10.2147/IJN.S385679
Source: Atherosclerosis - January 5, 2023 Category: Cardiology Authors: Yingfeng Tu Xiaowei Ma Hao Chen Yuhua Fan Lei Jiang Ruiping Zhang Zhen Cheng Source Type: research
Targeted Treatment of Triple-Negative-Breast Cancer Through pH-Triggered Tumour Associated Macrophages Using Smart Theranostic Nanoformulations
Int J Pharm. 2023 Jan 2:122575. doi: 10.1016/j.ijpharm.2022.122575. Online ahead of print.ABSTRACTTriple-negative breast cancer (TNBC) represents 15-25% of the new breast cancer cases diagnosed worldwide every year. TNBC is among the most aggressive and worst prognosis breast cancer, mainly because targeted therapies are not available. Herein, we developed a magnetic theranostic hybrid nanovehicle for targeted treatment of TNBC through pH-triggered tumour associated macrophages (TAMs) targeting. The lipid core of the nanovehicle was composed of a Carnaúba wax matrix that simultaneously incorporated iron oxide nanoparticle...
Source: Cancer Control - January 5, 2023 Category: Cancer & Oncology Authors: Stefania Scialla Mahmoud S Hanafy Jie-Liang Wang Nuria Genicio Milene Silva Marta Costa Sofia Oliveira-Pinto F átima Baltazar Juan Gallo Zhengrong Cui Manuel Ba ñobre-López Source Type: research
Preclinical Identification Of Tumor-Draining Lymph Nodes Using a Multimodal Non-invasive In vivo Imaging Approach
CONCLUSIONS: When taken together, our results demonstrate the feasibility of 18F-FDG-PET/MRI as a valid method for non-invasive in vivo, intraoperative, and ex vivo identification of the lymphatic drainage and glucose metabolism within the TDLNs. In addition, using Patent Blue V provides additive value for the macroscopic localization of the lymphatic drainage both visually and by ex vivo optical imaging analysis. Thus, both methods are valuable, easy to implement, and cost-effective for preclinical identification of the TDLN.PMID:36600172 | DOI:10.1007/s11307-022-01797-z
Source: Molecular Medicine - January 4, 2023 Category: Molecular Biology Authors: Philipp Knopf Dimitri Stowbur Sabrina H L Hoffmann Marieke F Fransen Johannes Schwenck Bernd J Pichler Manfred Kneilling Source Type: research
Synthesis of < sup > 19 < /sup > F MRI Nanotracers by Dispersion Polymerization-Induced Self-Assembly of < em > N < /em > -(2,2,2-Trifluoroethyl)acrylamide in Water
Biomacromolecules. 2022 Oct 17. doi: 10.1021/acs.biomac.2c00981. Online ahead of print.ABSTRACT19F magnetic resonance imaging (MRI) using fluoropolymer tracers has recently emerged as a promising, non-invasive diagnostic tool in modern medicine. However, despite its potential, 19F MRI remains overlooked and underused due to the limited availability or unfavorable properties of fluorinated tracers. Herein, we report a straightforward synthetic route to highly fluorinated 19F MRI nanotracers via aqueous dispersion polymerization-induced self-assembly of a water-soluble fluorinated monomer. A polyethylene glycol-based macromo...
Source: Biomacromolecules - October 17, 2022 Category: Biochemistry Authors: Vyshakh M Panakkal Dominik Havlicek Ewa Pavlova Marcela Filipov á Semira Bener Daniel Jirak Ondrej Sedlacek Source Type: research
Preparation and evaluation of LA-PEG-SPION, a targeted MRI contrast agent for liver cancer
This study aims to synthesize a magnetic resonance imaging (MRI) contrast agent that can specifically target the asialoglycoprotein receptor of liver cancer cells and evaluate its ability as a targeted MRI contrast agent. Lactobionic acid (LA) and polyethylene glycol (PEG) were used to modify superparamagnetic iron oxide nanoparticles (SPION) to obtain LA-PEG-SPION. LA-PEG-SPION was uniformly spherical under the electron microscope, with regular morphology and good dispersion. The particle size of LA-PEG-SPION was about 30 ± 4.5 nm, and its surface potential was about 31 ± 1.5 mV. LA-PEG-SPION had no toxicity or low toxi...
Source: Cancer Control - September 1, 2022 Category: Cancer & Oncology Authors: Lei Xia Xiaowei Song Guanghai Yan Jishan Quan Guangyu Jin Source Type: research
Construction of magnetic drug delivery system and its potential application in tumor theranostics
This study has successfully constructed a tumor-targeting and magnetic-targeting smart nanocarrier with enhanced permeability and retention, multimodal anti-cancer therapeutics and biodegradability, which could be a hopeful candidate for anti-tumor therapy in the future.PMID:36007274 | DOI:10.1016/j.biopha.2022.113545
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 25, 2022 Category: Drugs & Pharmacology Authors: Mingrui Jiang Qianqian Liu Yu Zhang Huinan Wang Jingqiu Zhang Mengyu Chen Zhuzhu Yue Zhicheng Wang Xiaotong Wei Shuanghui Shi Menglin Wang Yanglong Hou Zhiyi Wang Fugeng Sheng Ning Tian Yingzi Wang Source Type: research
Theranostic Copolymers Neutralize Reactive Oxygen Species and Lipid Peroxidation Products for the Combined Treatment of Traumatic Brain Injury
Biomacromolecules. 2022 Mar 22. doi: 10.1021/acs.biomac.1c01635. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) results in the generation of reactive oxygen species (ROS) and lipid peroxidation product (LPOx), including acrolein and 4-hydroxynonenal (4HNE). The presence of these biochemical derangements results in neurodegeneration during the secondary phase of the injury. The ability to rapidly neutralize multiple species could significantly improve outcomes for TBI patients. However, the difficulty in creating therapies that target multiple biochemical derangements simultaneously has greatly limited therapeut...
Source: Biomacromolecules - March 22, 2022 Category: Biochemistry Authors: Aaron Priester Richard Waters Ashleigh Abbott Krista Hilmas Klaus Woelk Hunter A Miller Aria W Tarudji Connor C Gee Brandon McDonald Forrest M Kievit Anthony J Convertine Source Type: research
Activatable MRI-monitoring gene delivery for the theranostic of renal carcinoma
In this study, we constructed a PEG-MnO2-OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo. This strategy of utilizing PEG-MnO2 nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T1-weight MRI, illustrating the promising potential of PEG-MnO2 nanosheets for the fabrication of an MRI-based theranostic system.
Source: Colloids and Surfaces B: Biointerfaces - December 8, 2019 Category: Biochemistry Source Type: research
Activatable MRI-monitoring gene delivery for the theranostic of renal carcinoma.
In this study, we constructed a PEG-MnO2-OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo. This strategy of utilizing PEG-MnO2 nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T1-weight MRI, illustrating the promising potential of PEG-MnO2 nanosheets for the fabrication of an MRI-based theranostic system.
PMID: 31734089 [PubMed - as supplied by publisher]
Source: Colloids and Surfaces - November 7, 2019 Category: Biotechnology Authors: Shi M, Wang S, Zheng S, Hou P, Dong L, He M, Wu C, Zhang X, Zuo F, Xu K, Li J Tags: Colloids Surf B Biointerfaces Source Type: research
Stealth magnetic nanocarriers of siRNA as platform for breast cancer theranostics
Publication date: 5 November 2017 Source:International Journal of Pharmaceutics, Volume 532, Issue 2 Author(s): J. Bruniaux, S. Ben Djemaa, K. Hervé-Aubert, H. Marchais, I. Chourpa, S. David The endogenous mechanism of RNA interference is more and more used in research to obtain specific down-regulation of gene expression in diseases such as breast cancer. Currently, despite the new fields of study open up by RNA interference, the rapid degradation of siRNA by nucleases and their negative charges prevent them from crossing cell membranes. To overcome these limitations, superparamagnetic iron oxide nanoparticles (SPIONs) ...
Source: International Journal of Pharmaceutics - October 11, 2017 Category: Drugs & Pharmacology Source Type: research
Modulating water-exchange rates of lanthanide(III)-containing polyaminopolycarboxylate-type complexes using polyethylene glycol
Dalton Trans., 2013, Advance ArticleDOI: 10.1039/C3DT50885D, CommunicationBuddhima N. Siriwardena-Mahanama, Matthew J. AllenWe have demonstrated that polyethylene glycol is able to tune the water-exchange rates of polyaminopolycarboxylate-type LnIII-containing complexes that will be useful in designing contrast agents for magnetic resonance imaging.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - April 19, 2013 Category: Chemistry Authors: Buddhima N. Siriwardena-Mahanama Source Type: research
