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Specialty: General Medicine
Drug: Aspirin

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Total 208 results found since Jan 2013.

Aortic stenosis in the elderly: The TAVI revolution.
Abstract TAVI is currently recommended for severe symptomatic aortic stenosis in patients at prohibitive, high or intermediate surgical risk as estimated by surgical risk scores (STS score and EuroSCORE II). Comorbidity, technical feasibility of TAVI and concurrent pathology with need for complementary surgical correction are conditions to be considered to choose between open surgery and TAVI. The decision is often made by the "Heart Team". The transfemoral access must be favored. Conduction disturbance, stroke, bioprosthesis thrombosis and durability are the main setbacks of TAVI. Double antiplatelet therapy with...
Source: Presse Medicale - December 10, 2018 Category: General Medicine Authors: Overtchouk P, Collet JP Tags: Presse Med Source Type: research

Clopidogrel plus aspirin versus aspirin alone for acute minor ischaemic stroke or high risk transient ischaemic attack: systematic review and meta-analysis
Source: BMJ - December 18, 2018 Category: General Medicine Source Type: research

Association of Aspirin Use for Primary Prevention of CVD With Cardiovascular Events and Bleeding
This meta-analysis estimates the association between use of aspirin for primary prevention of cardiovascular disease and the rate of cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, and bleeding.
Source: JAMA - January 22, 2019 Category: General Medicine Source Type: research

Clinical Considerations for Aspirin Use for Primary Prevention in 2019
Reducing platelet activity with aspirin and other antiplatelet agents is an important factor in the prevention and management of atherothrombotic vascular events. For this indication, aspirin has both beneficial and potentially harmful effects; it can diminish or reverse thrombus formation (eg, in the setting of acute myocardial infarction or stroke), but it also increases the risk of bleeding.
Source: JAMA - January 22, 2019 Category: General Medicine Source Type: research

The rise and fall of aspirin in the primary prevention of cardiovascular disease
Publication date: 25–31 May 2019Source: The Lancet, Volume 393, Issue 10186Author(s): Inbar Raber, Cian P McCarthy, Muthiah Vaduganathan, Deepak L Bhatt, David A Wood, John G F Cleland, Roger S Blumenthal, John W McEvoySummaryAspirin is one of the most frequently used drugs worldwide and is generally considered effective for the secondary prevention of cardiovascular disease. By contrast, the role of aspirin in primary prevention of cardiovascular disease is controversial. Early trials evaluating aspirin for primary prevention, done before the turn of the millennium, suggested reductions in myocardial infarction and stro...
Source: The Lancet - May 24, 2019 Category: General Medicine Source Type: research

Ticagrelor plus aspirin versus clopidogrel plus aspirin for platelet reactivity in patients with minor stroke or transient ischaemic attack: open label, blinded endpoint, randomised controlled phase II trial
Source: BMJ - June 7, 2019 Category: General Medicine Source Type: research

Effectiveness of polypill for primary and secondary prevention of cardiovascular diseases (PolyIran): a pragmatic, cluster-randomised trial
Publication date: 24–30 August 2019Source: The Lancet, Volume 394, Issue 10199Author(s): Gholamreza Roshandel, Masoud Khoshnia, Hossein Poustchi, Karla Hemming, Farin Kamangar, Abdolsamad Gharavi, Mohammad Reza Ostovaneh, Alireza Nateghi, Masoud Majed, Behrooz Navabakhsh, Shahin Merat, Akram Pourshams, Mahdi Nalini, Fatemeh Malekzadeh, Masoumeh Sadeghi, Noushin Mohammadifard, Nizal Sarrafzadegan, Mohammad Naemi-Tabiei, Abdolreza Fazel, Paul BrennanSummaryBackgroundA fixed-dose combination therapy (polypill strategy) has been proposed as an approach to reduce the burden of cardiovascular disease, especially in low-income ...
Source: The Lancet - August 23, 2019 Category: General Medicine Source Type: research

A Case of Isolated Unilateral Glossopharyngeal Nerve Palsy.
This article discusses the various etiologies and mechanisms of this rare condition. It is unique because of the nerve's location and relation to other structures. PMID: 31511240 [PubMed - as supplied by publisher]
Source: Clinical Medicine and Research - September 10, 2019 Category: General Medicine Authors: Savarimuthu MK, Nair AK Tags: Clin Med Res Source Type: research

Could Daily Low-Dose Aspirin Still Help Some People?
MONDAY, Sept. 16, 2019 -- Debate over the benefits and drawbacks of daily low-dose aspirin has flared in recent years, with guidelines now generally urging against the regimen to prevent a first heart attack or stroke in healthy people. But some...
Source: Drugs.com - Daily MedNews - September 16, 2019 Category: General Medicine Source Type: news

Platelet function, coagulation and fibrinolysis in patients with previous coronary and cerebrovascular ischemic events
CONCLUSION: Platelet aggregability, coagulation and endogenous fibrinolysis showed similar results among CAD patients with and without previous IS/TIA. Therefore, it remains necessary to identify other targets to explain the higher bleeding risk presented by these patients.
Source: Clinics - September 26, 2019 Category: General Medicine Source Type: research

The Anti-Platelet Anomaly: Aspirin/Dipyridamole-Induced Acute Pancreatitis
We present a case of aspirin/dipyridamole-induced pancreatitis in an elderly patient. There was no other evidence suggesting any other etiology of pancreatitis for this patient. According to the Naranjo Adverse Drug Reaction Probability Scale, the association of pancreatitis is a probable reaction due to aspirin/dipyridamole.2 Although rare, this severe complication illustrates how physicians and clinical pharmacists should be aware of the risk of pancreatitis with aspirin/dipyridamole and the consequences regarding secondary stroke prevention after it occurs.
Source: The American Journal of Medicine - November 17, 2019 Category: General Medicine Authors: Daniel J. DeSantis, Punam B. Patel, Ludmila Gerova, Derek W. Grady Tags: Diagnostic Dilemma Source Type: research

Association of lipoprotein(a) and major adverse cardiovascular events in patients with percutaneous coronary intervention.
Conclusions: Baseline serum Lp(a) can be used to predict MACEs in patients after PCI treatment, which was independent of LDL-C. PMID: 31749864 [PubMed]
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Elderly female with CHF complains of abdominal pain, nausea and vomiting, dizziness, and confusion for 5 days. What is the cause?
Author: V. Dimov, M.D.Reviewer: S. Randhawa, M.D.A 96-year-old African American female (AAF) was admitted from a nursing home with complaints of abdominal pain, nausea and vomiting (N/V), dizziness, confusion and double vision for 5 days. She was discharged from the hospital just 4 days ago. Digoxin was started during that previous hospitalization for control of tachycardia in atrial fibrillation. One day prior to discharge, digoxin level was 1.8 mg/mL and digoxin dose was decreased to 125 mcg PO Q 48 hr.Past medical history (PMH)Hypertension, atrial fibrillation, coronary artery disease, stroke, congestive heart failure.M...
Source: Clinical Cases and Images - August 2, 2009 Category: General Medicine Tags: Cardiology Intensive Care Toxicology Source Type: news

Aspirin and other non-steroidal anti-inflammatory drugs for the prevention of dementia.
CONCLUSIONS: There is no evidence to support the use of low-dose aspirin or other NSAIDs of any class (celecoxib, rofecoxib or naproxen) for the prevention of dementia, but there was evidence of harm. Although there were limitations in the available evidence, it seems unlikely that there is any need for further trials of low-dose aspirin for dementia prevention. If future studies of NSAIDs for dementia prevention are planned, they will need to be cognisant of the safety concerns arising from the existing studies. PMID: 32352165 [PubMed - in process]
Source: Cochrane Database of Systematic Reviews - April 29, 2020 Category: General Medicine Authors: Jordan F, Quinn TJ, McGuinness B, Passmore P, Kelly JP, Tudur Smith C, Murphy K, Devane D Tags: Cochrane Database Syst Rev Source Type: research

Baseline characteristics predicting clinical outcomes and serious adverse events in middle-aged hypertensive women: a sub-analysis of the SPRINT in women aged < 65 years.
CONCLUSION: Smoking, aspirin, CKD, black race, and age seemed as important baseline characteristics in follow-up of <65-year-old hypertensive women, also depending on therapeutic strategy. Clinicians are expected to consider these critical parameters for effective antihypertensive management that promotes better outcomes in this middle-aged female population. PMID: 32490642 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - June 4, 2020 Category: General Medicine Tags: Turk J Med Sci Source Type: research