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One-Year Outcomes After Minor Stroke or High-Risk Transient Ischemic Attack Clinical Sciences
Conclusions—Contemporary secondary stroke prevention strategies based on thorough diagnostic evaluation may contribute to the low subsequent vascular event rates observed in real-world clinical practice in Korea.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Tai Hwan Park, Sang-Soon Park, Kyung Bok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Byung-Chul Lee, Kyung-Ho Yu, M Tags: Quality and Outcomes, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Acute Ischemic Stroke as a Presenting Feature of Multiple Myeloma (P3.279)
Conclusions:Stroke is a leading and preventable cause of disability in the US adult population. The majority of strokes are due to atherosclerotic vascular or cardioembolic disease. Understanding the diagnostic work up of stroke and recognizing rare etiologies like MM is important for stroke prevention. This brings to light the importance of recognizing stroke as an initial presenting feature of multiple myeloma and of multiple myeloma as an important treatable etiology of stroke.Disclosure: Dr. Chung has nothing to disclose. Dr. Ramamoorthy has nothing to disclose. Dr. Kar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chung, S., Ramamoorthy, R., Kar, J. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Timing and mechanism of ischemic stroke due to extracranial blunt traumatic cerebrovascular injury.
Conclusions Most ischemic strokes due to TCVI are embolic in nature and occur prior to screening CTA and initiation of treatment with aspirin. PMID: 23216467 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - December 7, 2012 Category: Neurosurgery Authors: Griessenauer CJ, Fleming JB, Richards BF, Cava LP, Curé JK, Younan DS, Zhao L, Alexandrov AV, Barlinn K, Taylor T, Harrigan MR Tags: J Neurosurg Source Type: research

Safety of percutaneous coronary intervention in patients with acute ischemic stroke/transient ischemic attack and acute coronary syndrome
Conclusions The primary and secondary end points were not enhanced in patients undergoing PCI. Therefore PCI is safe in patients with stroke/TIA and concomitant ACS.
Source: Clinical Research in Cardiology - October 29, 2015 Category: Cardiology Source Type: research

Dual antiplatelet therapy in stroke and ICAS: Subgroup analysis of CHANCE
Conclusions: The results indicated higher rate of recurrent stroke in minor stroke or high-risk TIA patients with ICAS than in those without. However, there was no significant difference in the response to the 2 antiplatelet therapies between patients with and without ICAS in the CHANCE trial. Classification of evidence: This study provides Class II evidence that for patients with acute minor stroke or TIA with and without ICAS identified by MRA, clopidogrel plus aspirin is not significantly different than aspirin alone in preventing recurrent stroke.
Source: Neurology - September 28, 2015 Category: Neurology Authors: Liu, L., Wong, K. S. L., Leng, X., Pu, Y., Wang, Y., Jing, J., Zou, X., Pan, Y., Wang, A., Meng, X., Wang, C., Zhao, X., Soo, Y., Johnston, S. C., Wang, Y., For the CHANCE Investigators Tags: ARTICLE Source Type: research

Dabigatran etexilate: management in acute ischemic stroke.
Abstract A 54-year-old man treated with dabigatran experienced new onset of a stroke with a score of 9 on the National Institutes of Health Stroke Scale. Administration of recombinant tissue plasminogen activator (rtPA) was not recommended because of the dabigatran therapy. Angiography showed occlusion of the left middle cerebral artery by an embolic thrombus. Suction thrombectomy achieved flow through the inferior division of the artery. Computed tomography of the head showed possible intracranial hemorrhage, and dabigatran reversal was attempted with prothrombin complex concentrate and recombinant factor VIIa. C...
Source: American Journal of Critical Care - March 1, 2013 Category: Nursing Authors: Javedani PP, Horowitz BZ, Clark WM, Lutsep HL Tags: Am J Crit Care Source Type: research

A Markov model to compare the long-term effect of aspirin, clopidogrel and clopidogrel plus aspirin on prevention of recurrent ischemic stroke due to intracranial artery stenosis
Conclusion: To prevent recurrent stroke in patients with intracranial artery stenosis, especially in those patients with a history of TIA or coronary artery disease, medical therapy with clopidogrel plus aspirin should be considered in preference to aspirin alone.
Source: Neurology India - March 7, 2014 Category: Neurology Authors: Jinqiu YangLukui ChenNaveen ChitkaraQiang Xu Source Type: research

Recurrent right middle cerebral artery territory infarctions in a patient with JAK2 (V617F) point mutation positive polycythemia rubra vera (P2.258)
CONCLUSIONS: Hyperviscosity in polycythemia with hematocrit of more than 43[percnt] is known to cause ischemic events and it is evident in our case where our patient had recurrent ischemic strokes whenever the HCT is about 50[percnt] and the right MCA M1 segment though a mild stenosis, it becomes a critical factor for this patient as the patient had recurrent right MCA territory infarcts and hence in addition to regular phlebotomy to keep hematocrit less than 43[percnt], our patient might also need intervention in the form of cerebral angioplasty or stenting to treat even mild arterial stenosis. Study Supported by: ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Suri Mohanram, S., Nattanmai Chandrasekaran, P. Tags: Cerebrovascular Disease and Interventional Neurology: Genetics and Stroke Source Type: research

Aspirin for primary prevention of stroke in traumatic cerebrovascular injury: association with increased risk of transfusion.
CONCLUSIONS Treatment with aspirin for the prevention of stroke in patients with initially asymptomatic TCVI carries a significantly increased risk of PRBC transfusion. Future studies are needed to determine if this risk is offset by a reduced risk of ischemic stroke. PMID: 29775142 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - May 18, 2018 Category: Neurosurgery Authors: Griffin RL, Falatko SR, Aslibekyan S, Strickland V, Harrigan MR Tags: J Neurosurg Source Type: research

Final Results of Cilostazol-Aspirin Therapy against Recurrent Stroke with Intracranial Artery Stenosis (CATHARSIS)
Conclusion: Progression of IAS during the 2-year observation period appears to be less frequent than previously reported in stroke patients on antiplatelet agents after the acute phase, which could be due to the adequate control of risk factors, and because patients with stroke within 2 weeks after the onset were excluded. The results of the CATHARSIS trial suggest a potential utility of pharmacotherapies with cilostazol plus aspirin as well as of strict control of risk factors for the management of symptomatic IAS. Larger studies with higher statistical power are required to obtain conclusive results.Cerebrovasc Dis Extra 2015;5:1-13
Source: Cerebrovascular Diseases Extra - January 15, 2015 Category: Neurology Source Type: research

O-034 Carotid Artery Angioplasty versus Stenting in Acute Ischemic Stroke
Conclusions This data suggest that patients undergoing angioplasty alone in the setting of acute internal carotid artery occlusion may have improved functional outcome at 90-day compared to those undergoing stenting. This study was limited by a small sample size and a larger study would be needed to confirm these findings. Keywords angioplasty, stenting, acute ischemic stroke, carotid occlusion. Disclosures O. Choudhri: None. M. Gupta: None. A. Feroze: None. G. Albers: None. M. Lansberg: None. H. Do: None. R. Dodd: None. M. Marcellus: None. M. Marks: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2014 Category: Neurosurgery Authors: Choudhri, O., Gupta, M., Feroze, A., Albers, G., Lansberg, M., Do, H., Dodd, R., Marcellus, M., Marks, M. Tags: Oral abstracts Source Type: research

Predictors and Clinical Impact of Delayed Stent Thrombosis after Thrombectomy for Acute Stroke with Tandem Lesions INTERVENTIONAL
CONCLUSIONS: We observed a non-negligible rate of delayed stent thrombosis with significant negative impact on clinical outcome. Future studies should systematically measure and report stent patency rates.
Source: American Journal of Neuroradiology - March 13, 2019 Category: Radiology Authors: Pop, R., Zinchenko, I., Quenardelle, V., Mihoc, D., Manisor, M., Richter, J. S., Severac, F., Simu, M., Chibbaro, S., Rouyer, O., Wolff, V., Beaujeux, R. Tags: INTERVENTIONAL Source Type: research

Stenosis Length and Degree Interact With the Risk of Cerebrovascular Events Related to Internal Carotid Artery Stenosis
Conclusion: We found a statistically insignificant tendency for the ultrasound-measured length of sICAS<70% to be longer than that of sICAS≥70%. Moreover, the ultrasound-measured length of sICAS<90% was significantly longer than that of sICAS 90%. Among patients with sICAS≥70%, the degree and length of stenosis were inversely correlated. Larger studies are needed before a clinical implication can be drawn from these results. Introduction Internal carotid artery stenosis (ICAS) causes around one-fifth of ischemic cerebrovascular stroke and has the highest risk of early stroke recurrence...
Source: Frontiers in Neurology - April 8, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Blunt traumatic occlusion of the internal carotid and vertebral arteries.
Conclusions At the authors' institution, traumatic ICA occlusion is rare but associated with a high stroke rate. Robust collateral circulation may mitigate its severity. Embolic monitoring with TCD ultrasonography and prophylactic antiplatelet therapy should be used in all ICA Biffl Grade IV injuries. Unilateral VA Biffl Grade IV injury is the most common type of traumatic occlusion and is associated with significantly less morbidity. Embolic monitoring using TCD and prophylactic antiplatelet therapy do not appear to be beneficial in patients with traumatic VA occlusion. PMID: 24678781 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - March 28, 2014 Category: Neurosurgery Authors: Morton RP, Hanak BW, Levitt MR, Fink KR, Peterson EC, Vilela MD, Kim LJ, Chesnut RM Tags: J Neurosurg Source Type: research

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