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Drug: Estradiol

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Total 8747 results found since Jan 2013.

Liver metabolomic characteristics in three different rat models of deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
CONCLUSION: The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid, glycerophospholipid, and sphingolipid in SD rats.PMID:36994515 | PMC:PMC10012192 | DOI:10.19852/j.cnki.jtcm.20230201.001
Source: Journal of Traditional Chinese Medicine - March 30, 2023 Category: Complementary Medicine Authors: H U Xingyao Liu Hongning Yan Xiaojun Chen Zhong F U Liu Liu Ge Chen Xuan Shang Guangbin Source Type: research

Asparagine synthetase and G-protein coupled estrogen receptor are critical responders to nutrient supply in < em > KRAS < /em > mutant colorectal cancer
bioRxiv. 2023 May 5:2023.05.05.539577. doi: 10.1101/2023.05.05.539577. Preprint.ABSTRACTThe nutrient status of the tumor microenvironment has major impacts on cell growth. Under nutrient depletion, asparagine synthetase (ASNS)-mediated asparagine production increases to sustain cell survival. G protein-coupled estrogen receptor-1 (GPER1) signaling converges via cAMP/PI3K/AKT with KRAS signaling to regulate ASNS expression. However, the role of GPER1 in CRC progression is still debated, and the effect of nutrient supply on both ASNS and GPER1 relative to KRAS genotype is not well understood. Here, we modeled a restricted nu...
Source: Cancer Control - May 19, 2023 Category: Cancer & Oncology Authors: Lingeng Lu Qian Zhang Xinyi Shen Pinyi Zhen Audrey Marin Rolando Garcia- Milian Jatin Roper Sajid A Khan Caroline H Johnson Source Type: research

The role of genetics in estrogen responses: a critical piece of an intricate puzzle Reviews
The objectives of this review article were to summarize the current knowledge of the role of genotype, and uterine and neonatal environments, in phenotypic variation in the response to estrogens; to discuss recent findings and the potential mechanisms involved; and to highlight exciting research opportunities for the future.—Wall, E. H., Hewitt, S. C., Case, L. K, Lin, C.-Y., Korach, K. S., Teuscher, C. The role of genetics in estrogen responses: a critical piece of an intricate puzzle.
Source: FASEB Journal - December 1, 2014 Category: Biology Authors: Wall, E. H., Hewitt, S. C., Case, L. K., Lin, C.-Y., Korach, K. S., Teuscher, C. Tags: Reviews Source Type: research

Effects of estrogen deficiency and 17β-estradiol therapy on bone healing in calvarial critical size defects treated with bovine bone graft
To histomorphometrically analyze the effect of ovariectomy-induced estrogen deficiency and 17β-estradiol therapy on bone healing of surgically created critical-size defects (CSDs) treated with bovine bone graft (BBG).
Source: Archives of Oral Biology - January 28, 2015 Category: Dentistry Authors: Juliano Milanezi de Almeida, Alvaro Francisco Bosco, Paula Lazilha Faleiros, Victor Fabrizio Cabrera Pazmiño, Ana Cristina Murakawa, Samara Bonfante, Maria José Hitomi Nagata, Valdir Gouveia Garcia Source Type: research

Estradiol Is a Critical Mediator of Macrophage-Nerve Cross Talk in Peritoneal Endometriosis.
Abstract Endometriosis occurs in approximately 10% of women and is associated with persistent pelvic pain. It is defined by the presence of endometrial tissue (lesions) outside the uterus, most commonly on the peritoneum. Peripheral neuroinflammation, a process characterized by the infiltration of nerve fibers and macrophages into lesions, plays a pivotal role in endometriosis-associated pain. Our objective was to determine the role of estradiol (E2) in regulating the interaction between macrophages and nerves in peritoneal endometriosis. By using human tissues and a mouse model of endometriosis, we demonstrate th...
Source: Am J Pathol - June 11, 2015 Category: Pathology Authors: Greaves E, Temp J, Esnal-Zufiurre A, Mechsner S, Horne AW, Saunders PT Tags: Am J Pathol Source Type: research

The estrogen receptor alpha nuclear localization sequence is critical for fulvestrant-induced degradation of the receptor
In conclusion, our study provides evidence for the unique role of the ERα NLS in fulvestrant-induced degradation of the receptor. Graphical abstract
Source: Molecular and Cellular Endocrinology - September 21, 2015 Category: Endocrinology Source Type: research

17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B.
Authors: Wang H, Wu J Abstract Hyperoxia is a high risk factor for neurodevelopmental disorders and can cause nerve cell death. 17β‑Estradiol (E2) has been demonstrated as a neuroprotective agent. In the present study, the effect of hyperoxia on rat oligodendrocyte precursor cells (OPCs) in vivo and the neuroprotective effects of E2 on these cells were investigated. OPCs were treated with various concentrations of E2 and were harvested for reverse transcription‑quantitiative polymerase chain reaction (RT‑qPCR) analysis at various time‑points. RT‑qPCR analysis demonstrated that paired immunoglobin‑lik...
Source: Molecular Medicine Reports - January 30, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

A high dose mode of action for Tetrabromobisphenol A-induced uterine adenocarcinomas in Wistar Han rats: a critical evaluation of key events in an adverse outcome pathway framework.
Abstract TBBPA is a non-genotoxic flame retardant used to improve fire safety in a wide variety of consumer products. Estimated human exposures to TBBPA are very low (<0.000084 mg/kg-day), relative to the doses (500 and 1000 mg/kg-day of TBBPA) administered in a recent bioassay that resulted in uterine tumors in Wistar Han rats following chronic exposure. As part of an effort to characterize the relevance of the uterine tumors to humans, data and biological knowledge relevant to the progression of events associated with TBBPA-induced uterine tumors in female rats were organized in an adverse outcome pathway (AO...
Source: Regulatory Toxicology and Pharmacology : RTP - January 28, 2016 Category: Toxicology Authors: Wikoff DS, Rager JE, Haws LC, Borghoff SJ Tags: Regul Toxicol Pharmacol Source Type: research

Environmental impact of estrogens on human, animal and plant life: A critical review.
CONCLUSIONS: There is published evidence to establish a causal relationship between estrogens in the environment and breast cancer. However, there are serious gaps in our knowledge about estrogen levels in the environment and a call is required for a world wide effort to provide more data on many more samples sites. Of the data available, the synthetic estrogen, ethinyl estradiol, is more persistent in the environment than natural estrogens and may be a greater cause for environmental concern. Finally, we believe that there is an urgent requirement for inter-disciplinary studies of estrogens in order to better understand t...
Source: Environment International - December 27, 2016 Category: Environmental Health Authors: Adeel M, Song X, Wang Y, Francis D, Yang Y Tags: Environ Int Source Type: research

The critical role of uterine CD31 as a post-progesterone signal in early pregnancy
CD31 has been shown to play a role in endothelial cell migration and angiogenesis, which are critical to the formation and function of the endometrium and myometrium in uterine development during early pregnancy. However, the role of CD31 in uterine receptivity during blastocyst implantation is poorly understood. The pregnancy rate in CD31–/– female mice mated with CD31+/+ male mice was higher than that observed in CD31+/+ female mice mated with CD31+/+ male mice. During the receptive phase of implantation, uterine glands were more developed in CD31–/– mice than in CD31+/+ mice, and the uterine weig...
Source: Reproduction - October 5, 2017 Category: Reproduction Medicine Authors: Lee, S.-H., Kim, B.-J., Kim, U.-H. Tags: Research Source Type: research

Effect of HIFU on endometrial receptivity and sex hormone level in uterine fibroid patients and analysis of influencing factors for its treatment rate.
This study provides guidance for the clinical optimization of treatment methods and is more conducive to the promotion of HIFU ablation therapy. PMID: 30867713 [PubMed]
Source: Experimental and Therapeutic Medicine - March 15, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Primary antiphospholipid syndrome during aromatase inhibitors therapy: A case report and review of the literature
Rationale: Aromatase inhibitors (AIs) are a class of drugs widely used in the treatment of estrogen sensitive breast and ovarian cancer which convert testosterone to estradiol and androstenedione to estrogen. The AIs of third generation, including anastrazole, letrozole and exemestane, have actually become the standard of care of estrogen-receptor-positive breast cancer in menopausal women and are recommended as adjuvant treatment after surgery in place of/or following tamoxifen. Their main side-effects include reduction in bone mineral density, occurrence of menopausal manifestations and development of musculoskeletal s...
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research