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Drug: Estradiol

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Total 251 results found since Jan 2013.

Could Antibodies or Hormones Slow Brain Damage from Alzheimer’s?
Scientists have discovered that certain antibodies may help slow the progression of Alzheimer’s disease. Dr. Patricia Salinas of University College London, UK, and her team focused on a protein called Dkk1, present in raised levels in the brains of people with Alzheimer’s disease. Using brain samples from mice, the team looked at the progressive disintegration of synapses in the hippocampus when exposed to a protein called amyloid-beta, thought to be central to the development of Alzheimer’s disease. “Synaptic loss mediated by amyloid-beta in early stages of the disease might contribute to cognitive...
Source: Psych Central - June 1, 2013 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Disorders General Seniors Abnormal Deposits Alzheimer S Disease Antibodies Brain Area Brain Damage Cognitive Decline Cognitive Impairments Disintegration Dr Patricia Dr Simon Hippocampus Journal Of Neurosc Source Type: news

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro
Conclusions: Our results show an inhibitory action of progesterone in the aldosterone synthesis by chimeric or wild type aldosterone synthase enzymes. This is a novel regulatory mechanism of progesterone action, which could be involved in protecting pregnant women with FH-1 against hypertension. In vitro, both enzymes showed comparable kinetic parameters, but ASWT was more strongly inhibited than ASCE. This study implicates a new role for progesterone in the regulation of aldosterone levels that could contribute, along with other factors, to the maintenance of an adequate aldosterone-progesterone balance in pregnancy.
Source: Reproductive Biology and Endocrinology - August 13, 2013 Category: Endocrinology Authors: Andrea VecchiolaCarlos LagosCristóbal FuentesFidel AllendeCarmen CampinoCarolina ValdiviaAlejandra Tapia-CastilloTadashi OgishimaKuniaki MukaiGareth OwenSandra SolariCristian CarvajalCarlos Fardella Source Type: research

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
CONCLUSIONS: Our results show an inhibitory action of progesterone in the aldosterone synthesis by chimeric or wild type aldosterone synthase enzymes. This is a novel regulatory mechanism of progesterone action, which could be involved in protecting pregnant women with FH-1 against hypertension. In vitro, both enzymes showed comparable kinetic parameters, but ASWT was more strongly inhibited than ASCE. This study implicates a new role for progesterone in the regulation of aldosterone levels that could contribute, along with other factors, to the maintenance of an adequate aldosterone-progesterone balance in pregnancy. ...
Source: Reproductive Biology - August 13, 2013 Category: Reproduction Medicine Authors: Vecchiola A, Lagos CF, Fuentes CA, Allende F, Campino C, Valdivia C, Tapia-Castillo A, Ogishima T, Mukai K, Owen G, Solari S, Carvajal CA, Fardella CE Tags: Reprod Biol Endocrinol Source Type: research

CEE Raises Venous Thrombosis Risk vs Estradiol for Oral HRTCEE Raises Venous Thrombosis Risk vs Estradiol for Oral HRT
There was also a trend of increased MI risk but no signal of increased risk for ischemic stroke in the observational look at ischemic risk factors in women on HRT. Heartwire
Source: Medscape Today Headlines - October 1, 2013 Category: Consumer Health News Tags: Cardiology News Source Type: news

Long‐term safety of unopposed estrogen used by women surviving myocardial infarction: 14‐year follow‐up of the ESPRIT randomised controlled trial
ConclusionsThese results suggest that unopposed estrogen may be used safely by women with an intact uterus surviving a first myocardial infarction.
Source: BJOG: An International Journal of Obstetrics and Gynaecology - February 18, 2014 Category: OBGYN Authors: N Cherry, R McNamee, A Heagerty, H Kitchener, P Hannaford Tags: Original Article Source Type: research

Hyperpolarization-activated current-mediated slow afterhyperpolarization in myelinated Ah-type of baroreceptor neurons isolated from adult female rats
Compelling evidence indicates that baroreceptor/baroreflex dysfunction closely impacts on hypertension and CNS disorder, such as stroke . Baroreceptor neurons, with their mechanosensitive terminals and cell bodies located in aortic arch and nodose ganglia, receive the signals regarding blood pressure change and regulate the blood pressure quickly and efficiently through the baroreflex. Mechanosensitive terminals encode the pressure response into repetitive discharge that is received by baroreceptor neurons with various frequencies depending upon the blood pressure. From clinical point of view, nerve degenerative, such as P...
Source: International Journal of Cardiology - January 17, 2014 Category: Cardiology Authors: Li-Min Han, Tao Ban, Yang Liu, Mei Yuan, Jian-Li He, Xin Wen, Zhao Qian, Guo-Fen Qiao, Bai-Yan Li Tags: Online Letters to the Editor Source Type: research

Long-term safety of unopposed estrogen used by women surviving myocardial infarction: 14-year follow-up of the ESPRIT randomised controlled trial.
CONCLUSIONS: These results suggest that unopposed estrogen may be used safely by women with an intact uterus surviving a first myocardial infarction. PMID: 24533510 [PubMed - as supplied by publisher]
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 18, 2014 Category: OBGYN Authors: Cherry N, McNamee R, Heagerty A, Kitchener H, Hannaford P Tags: BJOG Source Type: research

Cardiovascular highlights from non-cardiology journals
Estrogen formulations have differing cardiovascular risk profile Ever since the publication of the Women's Health Initiative randomized trial that demonstrated clinical harm associated with use of conjugated equine estrogens, providers have been left in a challenging position in balancing the risk of these therapies against their benefit in treatment of menopausal symptoms. In the present study, the authors examined cardiac safety of oral conjugated equine estrogen vs. oral estradiol in a population-based case control study of post-menopausal women. Cases of venous thrombosis (n=68), myocardial infarction (n=67) or ischemi...
Source: Heart - May 19, 2014 Category: Cardiology Authors: Bradley, S. M. Tags: Journal scan Source Type: research

The neuroprotective effect of 17β-estradiol is independent of its antioxidative properties.
CONCLUSION: E2 is equally neuroprotective as antagonization of NMDA receptors while E2 analogues without hormonal activity are not neuroprotective. Therefore the current data suggest that the neuroprotection activity of E2 is independent of its free-radical scavenging properties. PMID: 25148707 [PubMed - as supplied by publisher]
Source: Brain Research - August 20, 2014 Category: Neurology Authors: Gröger M, Plesnila N Tags: Brain Res Source Type: research

Whether the use of unopposed oestrogen following a myocardial infarction is beneficial or harmful remains unclear, and in individual women the effects may vary according to the underlying risk profile
Commentary on: Cherry N, McNamee R, Heagerty A, et al.. Long-term safety of unopposed oestrogen used by women surviving myocardial infarction: a 14-year follow-up of the ESPRIT randomised controlled trial. BJOG 2014;121:700–5; discussion 705. Context There is a biological and epidemiological evidence to suggest that high oestrogen levels retard the progression of atherogenesis, reducing the risk of myocardial infarction. Whether such an effect is evident following a first myocardial infarction is unclear. A randomised controlled trial was carried out to investigate. Following completion of the trial the authors conti...
Source: Evidence-Based Medicine - September 15, 2014 Category: Internal Medicine Authors: Shapiro, S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Contraception, Drugs: obstetrics and gynaecology, Ischaemic heart disease, Vulvovaginal disorders Harm Source Type: research

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Abstract Oxidative stress-induced DNA damage results in over-activation of poly(ADP-ribose) polymerase 1 (PARP1), leading to parthanatos, a newly discovered cell elimination pathway. Inhibition of PARP1-dependent cell death has shown to improve the outcome of diseases, including stroke, heart ischemia, and neurodegenerative diseases. In the present study we aimed to detect whether estrogen plays a protective role in inhibiting parthanatos. We utilized human mammary adenocarcinoma cells (MCF7) that abundantly express the estrogen receptor alpha and beta (ERα and ERβ). Parthanatos was induced by challenging the ce...
Source: Toxicology Letters - September 30, 2014 Category: Toxicology Authors: Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio AA, Zeng X, Huo H, Han L, Boldogh I, Ba X Tags: Toxicol Lett Source Type: research

Evaluation of long-term pituitary functions in patients with severe ventricular arrhythmia: a pilot study
Conclusion The present preliminary study showed that ventricular arrhythmias may result in hypopituitarism, particularly in growth hormone deficiency. Unrecognized hypopituitarism may be responsible for some of the cardiovascular problems at least in some patients.
Source: Journal of Endocrinological Investigation - October 24, 2014 Category: Endocrinology Source Type: research

Estradiol and Progesterone Administration After pMCAO Stimulates the Neurological Recovery and Reduces the Detrimental Effect of Ischemia Mainly in Hippocampus
Abstract Epidemiological studies have suggested a differential response, males versus female, in stroke incidence and prognosis. These divergences in brain response after damage are based mostly on hormonal differences. To date, estradiol and progesterone administered independently have demonstrated neuroprotection after ischemia in animal models. Nonetheless, contradictory results were revealed using a combined administration. In order to evaluate the effects of combinatorial treatment administered after ischemia induction, we used two different approaches: in vivo and in vitro models. Male rats which underwent p...
Source: Molecular Neurobiology - November 7, 2014 Category: Neurology Source Type: research

Cigarette smoking has a positive and independent effect on testosterone levels.
Authors: Wang W, Yang X, Liang J, Liao M, Zhang H, Qin X, Mo L, Lv W, Mo Z Abstract Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men, several groups have studied the effects of cigarette smoking on testosterone levels in men. However, the results have been conflicting. Our objectives were to examine the association of cigarette smoking and serum levels of sex ho...
Source: Hormones - December 2, 2014 Category: Endocrinology Tags: Hormones (Athens) Source Type: research

Medical treatment of ureteral obstruction associated with ovarian remnants and/or endometriosis: report of 3 cases and review of the literature
Conclusions Low dose intermittent danazol or GnRH-a alone or with add-back, may be effective long-term therapies in endometriosis-associated ureteral obstruction when surgery is contraindicated, refused or difficult to perform.
Source: Journal of Minimally Invasive Gynecology - December 20, 2014 Category: OBGYN Source Type: research