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Drug: Metformin
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Probiotics in Metformin Intolerant Patients With Type 2 Diabetes
Conditions: Diabetes Mellitus, Type 2; Metformin Adverse Reaction Interventions: Dietary Supplement: Sanprobi Barrier-multispecies probiotic; Other: Placebo Comparator Sponsors: Medical University of Silesia; Sanprobi Sp. z o.o., Sp. k., Szczecin, Poland Recruiting
Source: ClinicalTrials.gov - September 13, 2019 Category: Research Source Type: clinical trials
AZ at it again
AUTH/2793/9/15 - Clinical pharmacist v AstraZenecaCase number:AUTH/2793/9/15Case ref:Clinical pharmacist v AstraZenecaDescription:Identifying patients suitable for Forxiga treatment and failing to provide an accurate response to the PanelNo breach:No breaches Clauses 2 and 7.2Breach:Breaches Clauses 3.2, 7.2 and 9.1. Corrective statement and public reprimand.Appeal:No appealReview:Published in the May 2016 ReviewReceived:10/09/2015Completed:17/03/20162793Case Summary:A clinical pharmacist complained about an AstraZeneca leavepiece about how to create a clinical system search to identify patients suitable for tr...
Source: PharmaGossip - September 27, 2016 Category: Pharmaceuticals Authors: insider Source Type: blogs
Law and Order? - Bristol-Myers-Squibb Settles Case Alleging Fraud and Kickbacks, No Admissions of Guilt, No Individuals Charged
Introduction Donald Trump, Republican candidate for the US presidency last week announced he is the " law and order " candidate, accompanied by then vice presidential contender and New Jersey Governor Chris Christie. I wonder if all this interest in law and order will lead to increasing the effectiveness of enforcing laws when large US health care corporations are accused? For years, we have been watching a parade of legal settlements made by big US health care organizations. These have included the biggest drug companies, biotechnology companies, device companies, insurance companies, etc, etc. ...
Source: Health Care Renewal - July 21, 2016 Category: Health Management Tags: Abilify Bristol-Myers-Squibb crime impunity kickbacks legal settlements logical fallacies Source Type: blogs
Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, December 2nd 2019
In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications.
To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence?
https://www.fightaging.org/archives/2019/11/to-what-degree-does-loss-of-skeletal-muscle-with-age-contribute-to-immunosenescence/
Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - December 1, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 5th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 4, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 27th 2016
In conclusion, we showed for the first time that 7-KC induces oxidative stress via lysosomal dysfunction, resulting in exacerbation of calcification.
CHIMERIC ANTIGEN RECEPTOR CANCER THERAPIES CAN NOW TARGET SOLID TUMORS
https://www.fightaging.org/archives/2016/06/chimeric-antigen-receptor-cancer-therapies-can-now-target-solid-tumors/
If the research community is to win in the fight to cure cancer, and win soon enough to matter for all of us, then the focus must be on technology platforms that can be easily and cheaply adapted to many different types of cancer. The biggest strategic problem in the field is tha...
Source: Fight Aging! - June 26, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Regenerative Potential of Platelet Rich Fibrin (PRF) for Curing Intrabony Periodontal Defects: A Systematic Review of Clinical Studies
The objectives are to critically analyze and appraise the currently available literature, focusing on the use of PRF in regenerating periodontal bone defects. An electronic search was conducted (PubMed/MEDLINE, Google Scholar, ISI-WOS). Various combinations of following keywords were used: ‘platelet-rich fibrin’, ‘intrabony’, ‘periodontal’, ‘bone defect’ and ‘guided tissue regeneration’. A secondary search was conducted by analyzing the reference lists of the articles obtained in initial search. The final search resulted in 13 randomized controlled trials being inc luded. In majority of studies, PRF res...
Source: Tissue Engineering and Regenerative Medicine - September 13, 2017 Category: Biotechnology Source Type: research
Fight Aging! Newsletter, December 25th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - December 24, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Effect of hypoglycemic agents on survival outcomes of lung cancer patients with diabetes mellitus: A meta-analysis
Conclusions:This meta-analysis demonstrated that metformin exposure might improve survival outcomes in lung cancer patients with diabetes.
Background:
To assess the association between hypoglycemic agents and prognosis of lung cancer patients with diabetes.
Methods:
A comprehensive literature search was performed in PubMed, Web of Science, Embase, and Cochrane Library until May 2017. The search yielded 2593 unique citations, of which 18 articles met inclusion criteria. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated by a fixed-effects or random-effects model.
Results:
The pooled HRs...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus.
CONCLUSIONS: There is inconclusive evidence whether M+S combination therapy compared with metformin plus another glucose-lowering intervention results in benefit or harm for most patient-important outcomes (mortality, SAEs, macrovascular and microvascular complications) with the exception of hypoglycaemia (more harm for M+S combination). No RCT reported on health-related quality of life.
PMID: 30998259 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - April 17, 2019 Category: General Medicine Authors: Madsen KS, Kähler P, Kähler LKA, Madsbad S, Gnesin F, Metzendorf MI, Richter B, Hemmingsen B Tags: Cochrane Database Syst Rev Source Type: research
Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia
Conclusion
Hem-irAEs are potentially life-threatening complications of ICIs that require a high level of clinical suspicion. Ir-TCP is amongst the most frequently reported hem-irAEs. Due to its low incidence and the lack of specific diagnostic criteria, ir-TCP may be underdiagnosed and possibly underreported. The diagnosis is based on exclusion of other causes of TCP together with clinical features that suggest an immune event such as the refractoriness to platelet transfusions and response to corticosteroids. During clinical development, a systematic analysis of ir-TCP cases at clinical study and program level is of outm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research
Fluoxetine for adults who are overweight or obese.
CONCLUSIONS: Low-certainty evidence suggests that off-label fluoxetine may decrease weight compared with placebo. However, low-certainty evidence suggests an increase in the risk for dizziness, drowsiness, fatigue, insomnia and nausea following fluoxetine treatment.
PMID: 31613390 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - October 14, 2019 Category: General Medicine Authors: Serralde-Zúñiga AE, Gonzalez Garay AG, Rodríguez-Carmona Y, Melendez G Tags: Cochrane Database Syst Rev Source Type: research
