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Drug: Diltiazem

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Total 13 results found since Jan 2013.

Effect of Nicorandil, Diltiazem, or Isosorbide Mononitrate for Oral Antispastic Therapy After Coronary Artery Bypass Grafting Using Radial Artery Grafts —A Pilot Randomized Controlled Trial (ASRAB-Pilot): Rationale and Study Protocol
ConclusionThis pilot trial will compare the preliminary effects of nicorandil, diltiazem, and isosorbide mononitrate on angiographic and clinical outcomes in patients who have undergone RA-CABG. Recruitment began in June 2020, and the estimated primary completion date is early 2023. Results of this study will provide much needed information for design of large confirmatory trials on the effectiveness of oral antispastic medications after RA-CABG.
Source: Advances in Therapy - July 11, 2023 Category: Drugs & Pharmacology Source Type: research

A rare cause of abdominal pain managed unconventionally: acute renal infarction caused by atrial fibrillation: a case report
ConclusionsAcute renal infarction from thromboembolism is a rare but serious complication of arterial fibrillation. More efficient and different options for intervention methods will benefit the treatment of this disease. Here, we report a combination therapeutic method that has not been used in acute renal infarction associated with arterial fibrillation, and which restored renal perfusion and prevented long-term kidney injury.
Source: Journal of Medical Case Reports - October 19, 2022 Category: General Medicine Source Type: research

The real world use of combined P-glycoprotein and moderate CYP3A4 inhibitors with rivaroxaban or apixaban increases bleeding
AbstractThe use of direct oral anticoagulants for stroke prevention in atrial fibrillation continues to rise. Certain populations may be at higher risk for increased drug exposure and adverse events. Pharmacokinetic studies suggest increased exposure of rivaroxaban and apixaban with combined P-gp and moderate CYP3A4 inhibitors but the clinical relevance of this is unknown. This retrospective cohort study included patients receiving rivaroxaban or apixaban from January 1, 2012 to December 31, 2016 with a moderate inhibitor (amiodarone, dronedarone, diltiazem, verapamil) for at least 3 months in the drug –drug interaction ...
Source: Journal of Thrombosis and Thrombolysis - January 9, 2020 Category: Hematology Source Type: research

MRI Tracking of iPS Cells-Induced Neural Stem Cells in Traumatic Brain Injury Rats.
In conclusion, using an in vivo MRI tracking technique to trace the fate of iPS cells-induced NSCs in host brain is feasible. PMID: 30574806 [PubMed - as supplied by publisher]
Source: Cell Transplantation - December 21, 2018 Category: Cytology Authors: Jiang L, Li R, Tang H, Zhong J, Sun H, Tang W, Wang H, Zhu J Tags: Cell Transplant Source Type: research

The Influence of Microneedles on the Percutaneous Penetration of Selected Antihypertensive Agents: Diltiazem Hydrochloride and Perindopril Erbumine.
Abstract It is well documented in the scientific literature that high blood pressure can lead to cardiovascular disease. Untreated hypertension has clinical consequences such as coronary artery disease, stroke or kidney failure. Diltiazem hydrochloride (DH), a calcium-channel blocker, and perindopril erbumine (PE), an inhibitor of the angiotensin converting enzyme are used for the management of hypertension. This project will examine the effect of microneedle rollers on the transport of DH and PE across pig ear skin. The use of the transcutaneous route of administration reduces and in sometimes eliminates the trau...
Source: Current Drug Delivery - July 30, 2018 Category: Drugs & Pharmacology Authors: Luu E, Ita KB, Morra MJ, Popova IE Tags: Curr Drug Deliv Source Type: research

Allicin improves cardiac function by protecting against apoptosis in rat model of myocardial infarction
ConclusionAllicin appears to exert a cardioprotective effect that may be linked to blocking Bcl-2/Bax signaling pathway-denpendent apoptosis, further improving cardiac function.
Source: Chinese Journal of Integrative Medicine - July 31, 2017 Category: Internal Medicine Source Type: research

Effect of Diltiazem on Exercise Capacity after Heart Transplantation
ConclusionsThis study showed that Diltiazem treatment reduces ST, may improve cardiac allograft function and exercise tolerance during the first year after HTx.This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - May 1, 2017 Category: Transplant Surgery Authors: Sara Varnado, Yael Peled ‐Potashnik, Ashley Huntsberry, Brian D Lowes, Ronald Zolty, Adam Burdorf, Elizabeth R Lyden, Michael J Moulton, John Y Um, Eugenia Raichlin Tags: Original Article Source Type: research

Allicin improves the cardiac function by protecting against apoptosis in rat model of myocardial infarction
Conclusion Allicin appears to exert a cardioprotective effect that may be linked to blocking Bcl-2/Bax signaling pathway-denpendent apoptosis, further improving cardiac function.
Source: Chinese Journal of Integrative Medicine - July 12, 2016 Category: Internal Medicine Source Type: research

Pial Collateral Reactivity During Hypertension and Aging: Understanding the Function of Collaterals for Stroke Therapy Basic Sciences
Conclusions— This study shows for the first time that LMAs from young and aged SHR are vasoconstricted and have impaired vasodilatory responses that may contribute to greater perfusion deficit and little penumbral tissue. These results also suggest that therapeutic opening of pial collaterals is possible during middle cerebral artery occlusion to create penumbral tissue and prevent infarct expansion.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Chan, S.-L., Sweet, J. G., Bishop, N., Cipolla, M. J. Tags: Animal Models of Human Disease, Endothelium/Vascular Type/Nitric Oxide, Vascular Biology, Cerebrovascular Disease/Stroke, Ischemic Stroke Basic Sciences Source Type: research

Risks of Adverse Events Following Coprescription of Statins and Calcium Channel Blockers: A Nationwide Population-Based Study
In this study, 5857 patients received coprescription of CYP3A4-metabolized statins and CCBs that inhibit CYP3A4. There were no differences in comorbidity or use of antihypertensive drugs between patients who received CYP3A4-metabolized statins and those who received non-CYP3A4-metabolized statins. Patients who received CYP3A4-metabolized statins had significantly higher risk of acute kidney injury (adjusted odds ratio [OR] = 2.12; 95% CI = 1.35–3.35), hyperkalemia (adjusted OR = 2.94; 95% CI = 1.36–6.35), acute myocardial infarction (adjusted OR = 1.55; 95% CI = 1.16–2.07), and acute ischemic ...
Source: Medicine - January 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Nesfatin-1 as a new positive inotrope in the goldfish (Carassius auratus) heart.
In conclusion, this is the first report showing that in teleosts, Nesfatin-1 potentiates mechanical cardiac performance, strongly supporting the evolutionary importance of the peptide in the control of the cardiac function of vertebrates. PMID: 26248227 [PubMed - as supplied by publisher]
Source: General and Comparative Endocrinology - August 4, 2015 Category: Endocrinology Authors: Mazza R, Gattuso A, Filice M, Cantafio P, Cerra MC, Angelone T, Imbrogno S Tags: Gen Comp Endocrinol Source Type: research

The Association of the Vanin-1 N131S Variant with Blood Pressure Is Mediated by Endoplasmic Reticulum-Associated Degradation and Loss of Function
by Ya-Juan Wang, Bamidele O. Tayo, Anupam Bandyopadhyay, Heming Wang, Tao Feng, Nora Franceschini, Hua Tang, Jianmin Gao, Yun Ju Sung, the COGENT BP consortium , Robert C. Elston, Scott M. Williams, Richard S. Cooper, Ting-Wei Mu, Xiaofeng Zhu High blood pressure (BP) is the most common cardiovascular risk factor worldwide and a major contributor to heart disease and stroke. We previously discovered a BP-associated missense SNP (single nucleotide polymorphism)–rs2272996–in the gene encoding vanin-1, a glycosylphosphatidylinositol (GPI)-anchored membrane pantetheinase. In the present study, we first replicated the asso...
Source: PLoS Genetics - September 18, 2014 Category: Genetics & Stem Cells Authors: Ya-Juan Wang et al. Source Type: research

Abstract 232: Parenteral Antihypertensive Use on the First Day of Hospitalization after Acute Ischemic Stroke: A US Population Study Poster Session II
Conclusion: Approximately 16% of AIS patients receive IV AH medication in the first 24 hours of admission in the US. The rate of early AH treatment has increased over time both overall and among those who did not receive rt-PA. Whether this is due to increasingly aggressive BP treatment by physicians or higher BP on admission among AIS patients is unclear. Contrary to recommendations, nicardipine was used infrequently. More evidence is required to justify specific AH agents for BP treatment in AIS.
Source: Circulation: Cardiovascular Quality and Outcomes - May 15, 2013 Category: Cardiology Authors: Wang, Y., McDonough, E., Adeoye, O., LaPensee, K., Crothers, T. C., Kleindorfer, D. Tags: Poster Session II Source Type: research