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Total 2168 results found since Jan 2013.

Risk and population attributable fraction of stroke subtypes in Japan
CONCLUSION: Although there are differences according to the subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.PMID:37460296 | DOI:10.2188/jea.JE20220364
Source: Journal of Epidemiology - July 17, 2023 Category: Epidemiology Authors: Hiroshi Yatsuya Kazumasa Yamagishi Yuanying Li Isao Saito Yoshihiro Kokubo Isao Muraki Manami Inoue Shoichiro Tsugane Hiroyasu Iso Norie Sawada Source Type: research

Development of a Risk Equation for the Incidence of Coronary Artery Disease and Ischemic Stroke for Middle-Aged Japanese　- Japan Public Health Center-Based Prospective Study.
CONCLUSIONS: Risk equations were developed to estimate the 10-year probability of CAD and ischemic stroke in Japanese people, using variables that are routinely obtained. PMID: 27087361 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 14, 2016 Category: Cardiology Authors: Yatsuya H, Iso H, Li Y, Yamagishi K, Kokubo Y, Saito I, Sawada N, Inoue M, Tsugane S Tags: Circ J Source Type: research

A differential expression of uncoupling protein-2 associates with renal damage in stroke-resistant spontaneously hypertensive rat/stroke-prone spontaneously hypertensive rat-derived stroke congenic lines
Conclusion: A differential UCP2 expression associates with different degree of renal damage upon Japanese diet in two SHRSR/SHRSP-derived stroke congenic lines through modulation of mitochondrial function, inflammation, and oxidative stress.
Source: Journal of Hypertension - August 3, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Kidney Source Type: research

High Dietary Saturated Fat is Associated with a Low Risk of Intracerebral Hemorrhage and Ischemic Stroke in Japanese but not in Non-Japanese: A Review and Meta-Analysis of Prospective Cohort Studies.
CONCLUSIONS: In Japanese but not in non-Japanese, a diet high in saturated fat is associated with a low risk of intracerebral hemorrhage and ischemic stroke. This may be due to differences in the range of intake of saturated fat, genetic susceptibility, incidence of lacunar infarction, and/or confounding factors such as dietary proteins. An intervention study targeting Japanese will be required to verify the causality. PMID: 29269706 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - December 23, 2017 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Minor Electrocardiographic ST-T Change and Risk of Stroke in the General Japanese Population.
CONCLUSIONS: Minor ST-T changes were particularly associated with a higher risk of stroke in subjects with hyperlipidemia and this association was independent of electrocardiographic left ventricular hypertrophy. PMID: 29681583 [PubMed - as supplied by publisher]
Source: Circulation Journal - April 20, 2018 Category: Cardiology Authors: Ishikawa J, Hirose H, Schwartz JE, Ishikawa S Tags: Circ J Source Type: research

Predictors of Cardioembolic Stroke in Japanese Patients with Atrial Fibrillation in the Fushimi AF Registry
Conclusions: In this population-based cohort of Japanese patients with AF, in addition to previous stroke/TIA and older age, sustained AF and low body weight emerged as risk factors for CES, as opposed to any stroke, which may have a different risk profile. Patients with CKD or previous stroke/TIA who developed cardioembolic infarction exhibited more advanced severity. There is a need for direct oral anticoagulants that can be used safely in patients with comorbid AF and CKD.Cerebrovasc Dis Extra 2018;8:50 –59
Source: Cerebrovascular Diseases Extra - May 29, 2018 Category: Neurology Source Type: research

Systematic Understanding of the Mechanism of Baicalin against Ischemic Stroke through a Network Pharmacology Approach.
Authors: Xu T, Ma C, Fan S, Deng N, Lian Y, Tan L, Du W, Zhang S, Liu S, Ren B, Li Z, Wang Q, Wang X, Cheng F Abstract Ischemic stroke is accompanied by high mortality and morbidity rates. At present, there is no effective clinical treatment. Alternatively, traditional Chinese medicine has been widely used in China and Japan for the treatment of ischemic stroke. Baicalin is a flavonoid extracted from Scutellaria baicalensis that has been shown to be effective against ischemic stroke; however, its mechanism has not been fully elucidated. Based on network pharmacology, we explored the potential mechanism of baicalin ...
Source: Evidence-based Complementary and Alternative Medicine - January 17, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke.
Abstract Ischemic stroke is one of the leading causes of severe disability and death. In clinical settings, tissue plasminogen activator (t-PA) for thrombolytic therapy is the only globally approved drug for the treatment of ischemic stroke. However, the proportion of patients who receive t-PA therapy is extremely limited due to its narrow therapeutic time window (TTW) and the risk of cerebral hemorrhage. Cerebral ischemia-reperfusion (I/R) injury is also a serious problem for patients' outcomes. Hence, the development of more effective therapies has been desired to prolong the TTW of t-PA and prevent cerebral I/R...
Source: Biological and Pharmaceutical Bulletin - March 6, 2019 Category: Drugs & Pharmacology Authors: Fukuta T, Ishii T, Asai T, Oku N Tags: Biol Pharm Bull Source Type: research

Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Kazunori Toyoda, Shinichiro Uchiyama, Takenori Yamaguchi, J Donald Easton, Kazumi Kimura, Haruhiko Hoshino, Nobuyuki Sakai, Yasushi Okada, Kortaro Tanaka, Hideki Origasa, Hiroaki Naritomi, Kiyohiro Houkin, Keiji Yamaguchi, Masanori Isobe, Kazuo Minematsu, Shinya Goto, Tatsuya Isomura, Masayasu Matsumoto, Yasuo Terayama, Hidekazu TomimotoSummaryBackgroundAlthough dual antiplatelet therapy with aspirin and clopidogrel reduces early recurrence of ischaemic stroke, with long-term use this type of therapy is no longer effective and the risk of...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research

Development of Quality Indicators of Stroke Centers and Feasibility of Their Measurement Using a Nationwide Insurance Claims Database in Japan 　- J-ASPECT Study.
CONCLUSIONS: We developed QIs for primary and comprehensive stroke care. The DPC database may allow efficient data collection at low cost and decreased burden to evaluate the developed QIs. PMID: 31554766 [PubMed - as supplied by publisher]
Source: Circulation Journal - September 25, 2019 Category: Cardiology Authors: Nishimura A, Nishimura K, Onozuka D, Matsuo R, Kada A, Kamitani S, Higashi T, Ogasawara K, Shimodozono M, Harada M, Hashimoto Y, Hirano T, Hoshino H, Itabashi R, Itoh Y, Iwama T, Kohriyama T, Matsumaru Y, Osato T, Sasaki M, Shiokawa Y, Shimizu H, Takekawa Tags: Circ J Source Type: research

Serum Matrix Metalloproteinase-9 Is Associated With Depression After Acute Ischemic Stroke.
CONCLUSIONS: Elevated serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of PSD, suggesting an important prognostic role of MMP-9 for PSD. PMID: 31564697 [PubMed - as supplied by publisher]
Source: Circulation Journal - September 26, 2019 Category: Cardiology Authors: Che B, Zhong C, Ge J, Li R, Zhu Z, Bu X, Xu T, Ju Z, Liu J, Zhang J, Chen J, Zhang Y, He J Tags: Circ J Source Type: research

Review of Toyoda K, et al. Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischemic stroke in Japan. Lancet Neurol. 2019 Jun;18(6):539-548.
Conclusion: This RCT demonstrated the safety of dual therapy, consisting of cilostazol/aspirin or cilostazol/ clopidogrel, in preventing secondary ischemic stroke in a high-risk Japanese population. Further studies are required to generalize these findings to other patient populations worldwide. PMID: 32363048 [PubMed]
Source: Surgical Neurology International - May 5, 2020 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Reliability and validity of the Activities-specific Balance Confidence scale-Japanese (ABC-J) in community-dwelling stroke survivors.
CONCLUSION: ABC-J is a valid and reliable measurement tool for investigating balance confidence among patients ≥6 months after stroke. PMID: 32850274 [PubMed]
Source: Physical Therapy - August 28, 2020 Category: Physiotherapy Authors: Ishige S, Wakui S, Miyazawa Y, Naito H Tags: Phys Ther Res Source Type: research

Role of Remote Monitoring in Detection of Atrial Arrhythmia, Stroke Reduction, and Use of Anticoagulation Therapy 　- A Systematic Review and Meta-Analysis.
CONCLUSIONS: RM is effective for atrial arrhythmia detection in patients using wearable devices and for reducing the risk of stroke in patients with CIED. PMID: 33012748 [PubMed - as supplied by publisher]
Source: Circulation Journal - October 1, 2020 Category: Cardiology Authors: Jang JP, Lin HT, Chen YJ, Hsieh MH, Huang YC Tags: Circ J Source Type: research

Estimation of 10-Year Risk of Death from Coronary Heart Disease, Stroke, and Cardiovascular Disease in a Pooled Analysis of Japanese Cohorts: EPOCH-JAPAN.
CONCLUSIONS: Risk equations in the present study can adequately estimate the absolute 10-year risk of death from CHD, stroke, and CVD. Future work will evaluate the system as an education and risk communication tool for primary prevention of CHD and stroke. PMID: 33041313 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - October 14, 2020 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research