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Drug: Polyethylene Glycol
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Total 53 results found since Jan 2013.

Hyperoside Nanomicelles Alleviate Atherosclerosis by Modulating the Lipid Profile and Intestinal Flora Structure in High-Fat-Diet-Fed Apolipoprotein-E-Deficient Mice
Molecules. 2023 Jun 29;28(13):5088. doi: 10.3390/molecules28135088.ABSTRACTAtherosclerosis (AS) is a serious threat to human health and the main pathological basis of cardiovascular disease. Hyperoside (Hyp), a flavonoid found mainly in traditional Chinese herbs, can exert antitumor, anti-inflammatory, antioxidant, and cardiovascular-protective effects. Herein, we prepared hybrid nanomicelles (HFT) comprising Hyp loaded into pluronic F-127 and polyethylene glycol 1000 vitamin E succinate and assessed their effects on AS. To establish an AS model, apolipoprotein-E-deficient (ApoE-/-) mice were fed a high-fat diet. We then a...
Source: Atherosclerosis - July 14, 2023 Category: Cardiology Authors: Yuwen Shi Mengcheng Jiang Yuhang Zhang Yuanyuan Diao Na Li Weipeng Liu Zhidong Qiu Ye Qiu Ailing Jia Source Type: research

Ganoderenic acid D-loaded functionalized graphene oxide-based carrier for active targeting therapy of cervical carcinoma
Biomed Pharmacother. 2023 Jun 1;164:114947. doi: 10.1016/j.biopha.2023.114947. Online ahead of print.ABSTRACTGanoderenic acid D (GAD), extracted from the Chinese herb Ganoderma lucidum, was loaded onto a graphene oxide-polyethylene glycol-anti-epidermal growth factor receptor (GO-PEG-EGFR) carrier to develop a targeting antitumor nanocomposite (GO-PEG@GAD). The carrier was fabricated from PEG and anti-EGFR aptamer modified GO. Targeting was mediated by the grafted anti-EGFR aptamer, which targets the membrane of HeLa cells. Physicochemical properties were characterized by transmission electron microscopy, dynamic light sca...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 3, 2023 Category: Drugs & Pharmacology Authors: Jiahui Lu Anqiang Zhang Fuming Zhang Robert J Linhardt Zhihui Zhu Yanzi Yang Tinghuang Zhang Zhibin Lin Su Zhang Huajun Zhao Peilong Sun Source Type: research

Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Comparison of PEG precipitation and ultrafiltration treatment for serum macroprolactin in Chinese patients with hyperprolactinemia
CONCLUSION: The incidence of macroprolactinemia in Chinese patients with HPRL is low in the present study. Based on our analysis, we recommend that only patients who are clinically suspected of having macroprolactinemia should be screened using PEG precipitation.PMID:37086942 | DOI:10.1016/j.cca.2023.117358
Source: International Journal of Clinical Chemistry - April 22, 2023 Category: Chemistry Authors: Xiaoan Ke Linjie Wang Lian Duan Hongbo Yang Jia Yin Ling Qiu Hui Pan Fengying Gong Huijuan Zhu Source Type: research

Long-term pegylated growth hormone for children with growth hormone deficiency: a large, prospective, real-world study
CONCLUSIONS: PEG-rhGH showed long-term effectiveness and safety in treating children with GHD. Both dose subgroups showed promising outcomes, while PEG-rhGH 0.2 mg/kg/week might show additional benefit.PMID:36669772 | DOI:10.1210/clinem/dgad039
Source: The Journal of Clinical Endocrinology and Metabolism - January 20, 2023 Category: Endocrinology Authors: Ling Hou Ke Huang Chunxiu Gong Feihong Luo Haiyan Wei Liyang Liang Hongwei Du Jianping Zhang Yan Zhong Ruimin Chen Xinran Chen Jiayan Pan Xianjiang Jin Ting Zeng Wei Liao Deyun Liu Dan Lan Shunye Zhu Zhiya Dong Huamei Ma Yu Yang Feng Xiong Ping Lu Mb Shen Source Type: research

Effect of Polyethylene Glycol 400 on the Pharmacokinetics and Tissue Distribution of Baicalin by Intravenous Injection Based on the Enzyme Activity of UGT1A8/1A9
In conclusion, our results demonstrated that PEG400 interaction with UGTs altered the pharmacokinetic behaviors and tissue distribution characteristics of BG and its metabolites in rats.PMID:36379359 | DOI:10.1016/j.ejps.2022.106328
Source: European Journal of Pharmaceutical Sciences - November 15, 2022 Category: Drugs & Pharmacology Authors: Le-Yuan Shang Ming-Hao Zhou Si-Yuan Cao Min Zhang Peng-Jiao Wang Shuo Zhang Xiao-Xia Meng Qi-Mei Yang Xiu-Li Gao Source Type: research

Modulation mechanism of phytotoxicity on Ipomoea aquatica Forssk. by surface coating-modified copper oxide nanoparticles and its health risk assessment
Environ Pollut. 2022 Sep 27:120288. doi: 10.1016/j.envpol.2022.120288. Online ahead of print.ABSTRACTTo evaluate the influence of surface coatings on nano-fertilizers uptake and their phytotoxicity to crops and its health risk to Chinese adults, trisodium citrate (TC) and polyethylene glycol (PEG) coatings were prepared on the surface of copper oxide nanoparticles (CuO NPs), respectively, with 100 and 500 mg/L of bare CuO NPs, TC-CuO NPs, and PEG-CuO NPs were exposed to soil-grown Ipomoea aquatica Forssk. Combined bio-transmission electron microscopy and micro-CT observed cellular migration of coated CuO NPs in symplastic ...
Source: Environmental Pollution - September 30, 2022 Category: Environmental Health Authors: Yue Huang Xue Bai Chang Li Meng'en Kang Yuzhu Weng Dongqing Gong Source Type: research

Characterization of an Endophytic Antagonistic Bacterial Strain < em > Bacillus halotolerans < /em > LBG-1-13 with Multiple Plant Growth-Promoting Traits, Stress Tolerance, and Its Effects on Lily Growth
This study was aimed at isolating and identifying endophytic antagonistic bacteria from lily (Lilium davidii var. unicolor) roots grown in Northwestern China and at evaluating their antifungal activity and plant growth-promoting characteristics. For this purpose, endophytic bacteria were isolated from plant roots, and plant growth-promoting strains were identified. One bacterial strain, isolated from the root part, was identified as Bacillus halotolerans based on 16S rRNA gene sequence analysis and was designated as LBG-1-13. The strain showed antagonistic activities against important plant pathogens of lily including Botr...
Source: Biomed Res - September 5, 2022 Category: Research Authors: Jun-Lian Gao Mohammad Sayyar Khan Yu-Chen Sun Jing Xue Yunpeng Du Chunhong Yang Vladimir K Chebotar Vladimir S Tikunov Ivan N Rubanov Xuqing Chen Xiuhai Zhang Source Type: research

Low-dose of magnesium sulfate solution was not inferior to standard regime of polyethylene glycol for bowel preparation in elderly patients: a randomized, controlled study
CONCLUSIONS: Low dose of MSS was not inferior to the standard PEG regime in terms of bowel preparation quality for elderly patients. Low-dose MSS offered fewer adverse events and better tolerability. It is a preferable choice for the elderly to undergo bowel preparation for colonoscopy.CLINICAL TRIAL REGISTRATION NUMBER: NCT04948567.PMID:35920250 | DOI:10.1080/00365521.2022.2106154
Source: Cancer Control - August 3, 2022 Category: Cancer & Oncology Authors: Fulin Ge Xiaoyu Kang Zeyu Wang Hailan Zhu Liang Liao Ming Wang Jianjun Jia Lijun Lou Xuegang Guo Yanglin Pan Jun Wan Source Type: research

Preparation and in vitro release of mPEG-PLA microspheres of Panax notoginseng saponins
This study was performed to promote the clinical application of Panax notoginseng saponins (PNS), which present anti-inflammatory and antitumor activities, and provided insights for the preparation of controlled-release dosage forms of traditional Chinese medicine. A series of drug-loaded microspheres with degradable amphiphilic polymer material polyethylene glycol monomethyl ether-polylactic acid (mPEG-PLA) as the carrier was synthesized. The degradation, sustained-release behavior, and biocompatibility of the drug-loaded microspheres were studied through in vitro release, degradation, hemolysis, anticoagulation, and cyto...
Source: International Journal of Biological Macromolecules - July 31, 2022 Category: Biochemistry Authors: Penghao Zhang Ruimin Tang Shilong Yang Dengbang Jiang Minglong Yuan Hongli Li Mingwei Yuan Source Type: research

Microplastics in urban soils of Nanjing in eastern China: Occurrence, relationships, and sources
Chemosphere. 2022 May 17:134999. doi: 10.1016/j.chemosphere.2022.134999. Online ahead of print.ABSTRACTAlthough microplastic (MP) pollution has been defined as a new global challenge by the United Nations Environment Programme, their abundance and composition has only been studied in-depth within farmland soil, while minimal attention has been placed on urban soil contamination. Accordingly, within the current study, MP abundance and composition is investigated within urban soil from green spaces in Nanjing, eastern China. The average MP abundance in soil was 461 ± 222 items/kg and primarily comprised fibers (39.1%) and f...
Source: Chemosphere - May 20, 2022 Category: Chemistry Authors: Yujie Zhou Junxiao Wang Mengmeng Zou Qiqi Yin Yifei Qiu Chengqiang Li Bei Ye Tianwei Guo Zhenyi Jia Yan Li Chunhui Wang Shenglu Zhou Source Type: research