Filtered By:
Vaccination: Malaria Vaccine

This page shows you your search results in order of relevance. This is page number 16.

Order by Relevance | Date

Total 1933 results found since Jan 2013.

A Systematic Review of the Incidence, Risk Factors and Case Fatality Rates of Invasive Nontyphoidal < i > Salmonella < /i > (iNTS) Disease in Africa (1966 to 2014)
In conclusion, iNTS disease is a substantial cause of community-acquired bacteraemia in Africa. Given the high morbidity and mortality of iNTS disease in Africa, it is important to develop effective prevention and control strategies including vaccination.
Source: PLoS Neglected Tropical Diseases - January 4, 2017 Category: Tropical Medicine Authors: Ifeanyi Valentine Uche Source Type: research

The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development.
Abstract Analysis of our Plamodium falciparum malaria parasite peptides' (1)H-NMR database in the search for H-bonds and π-interactions led us to correlate their presence or absence with a peptide's particular immunological behavior. It was concluded that a 26.5 ± 1.5 Å between positions 1 to 9 of the HLA-DRβ1* interacting region was necessary for proper docking of 20mer-long peptides and these MHC Class II molecules for full-protective immunity. Presence of intramolecular H-bonds or π-interactions leading to righ-handed α-helix or β-turn conformation in this peptide's region induces different immune res...
Source: Biochemical and Biophysical Research communications - January 18, 2017 Category: Biochemistry Authors: Reyes C, Moreno-Vranich A, Patarroyo ME Tags: Biochem Biophys Res Commun Source Type: research

Synthesis, antimalarial activity in vitro and docking studies of novel neolignan derivatives
This article is protected by copyright. All rights reserved. Synthesis and docking studies of new neolignan derivatives with antimalarial activity.
Source: Chemical Biology and Drug Design - February 27, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: Research Article Source Type: research

How Hepatitis Became A Hidden Epidemic In Africa
This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Healthy Living - The Huffington Post - March 10, 2017 Category: Consumer Health News Source Type: news

Synthesis, antimalarial activity in vitro, and docking studies of novel neolignan derivatives
The absence of effective vaccines against malaria and the difficulties associated with controlling mosquito vectors have left chemotherapy as the primary control measure against malaria. However, the emergence and spread of parasite resistance to conventional antimalarial drugs result in a worrisome scenario making the search for new drugs a priority. In the present study, the activities of nine neolignan derivatives were evaluated as follows: (i) against blood forms of chloroquine‐resistant Plasmodium falciparum (clone W2), using the tritiated hypoxanthine incorporation and anti‐HRPII assays; (ii) for cytotoxic activi...
Source: Chemical Biology and Drug Design - April 6, 2017 Category: Biology Authors: Gla écia A. N. Pereira, Gisele C. Souza, Lourivaldo S. Santos, Lauro E. S. Barata, Carla C. F. Meneses, Antoniana U. Krettli, Cláudio Tadeu Daniel‐Ribeiro, Cláudio Nahum Alves Tags: RESEARCH ARTICLE Source Type: research

Chemical Attenuation in the Development of a Whole-Organism Malaria Vaccine Minireviews
Malaria vaccine development has been dominated by the subunit approach; however, many subunit vaccine candidates have had limited efficacy in settings of malaria endemicity. As our search for an efficacious malaria vaccine continues, the development of a whole-organism vaccine is now receiving much scrutiny. One strategy currently being explored in the development of a whole-organism vaccine involves chemical attenuation of the malaria parasite. In vivo and in vitro chemical attenuation of both liver-stage and blood-stage Plasmodium parasites has been investigated. Here, we discuss both approaches of chemical attenuation i...
Source: Infection and Immunity - June 20, 2017 Category: Infectious Diseases Authors: Raja, A. I., Stanisic, D. I., Good, M. F. Tags: Minireviews Source Type: research

Philanthropists Join Forces to Fund Africa ’s Cash-Strapped Health Sector
Tristate Heart and Vascular Centre in Nigeria. Credit: Tristate Heart and Vascular CentreBy Pavithra Rao, Africa Renewal*NEW YORK, Sep 28 2017 (IPS)In the 2017 World Happiness Report by Gallup, African countries score poorly. Of the 150 countries on the list, the Central African Republic, Tanzania and Burundi rank as the unhappiest countries in the world. Some of the factors driving unhappiness are the poor state of the continent’s health care systems, the persistence of HIV/AIDS, malaria and tuberculosis, and the growth of lifestyle diseases such as hypertension, heart disease and diabetes.Few African countries make sig...
Source: IPS Inter Press Service - Health - September 28, 2017 Category: International Medicine & Public Health Authors: Pavithra Rao Tags: Development & Aid Featured Global Headlines Health TerraViva United Nations Source Type: news

Quantitative Outcomes of a One Health approach to Study Global Health Challenges
AbstractHaving gained momentum in the last decade, the One Health initiative promotes a holistic approach to address complex global health issues. Before recommending its adoption to stakeholders, however, it is paramount to first compile quantitative evidence of the benefit of such an approach. The aim of this scoping review was to identify and summarize primary research that describes monetary and non-monetary outcomes following adoption of a One Health approach. An extensive literature search yielded a total of 42,167 references, of which 85 were included in the final analysis. The top two biotic health issues address...
Source: EcoHealth - January 12, 2018 Category: Environmental Health Source Type: research

Anti-Infectious Human Vaccination in Historical Perspective.
Authors: D'Amelio E, Salemi S, D'Amelio R Abstract A brief history of vaccination is presented since the Jenner's observation, through the first golden age of vaccinology (from Pasteur's era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be developed...
Source: International Reviews of Immunology - January 30, 2018 Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research

Fresh search for a vaccine against malaria parasite Plasmodium vivax
Hundreds of millions of people each year are infected with Plasmodium vivax, the most widespread form of malaria worldwide. An EU-funded project is tackling the mosquito-borne parasite, leading cutting-edge research efforts to accelerate the development of effective vaccines.
Source: EUROPA - Research Information Centre - April 25, 2018 Category: Research Source Type: news

Composition and mode of action of adjuvants in licensed viral vaccines.
In this report, adjuvants that are components of vaccines licensed in the EU will be presented and their mode of action will be discussed.Aluminum salts have been used for almost a century as vaccine adjuvants. In recent years numerous novel immune-stimulating substances have been developed and integrated into licensed human vaccines. These novel adjuvants are not only intended to generally increase the vaccine-induced antibody titers, but are also aimed at modulating and triggering a specific immune response. The search for innovative adjuvants was considerably stimulated during development of pandemic influenza vaccine...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - March 3, 2019 Category: International Medicine & Public Health Authors: Wagner R, Hildt E Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research

Updated insights into the mechanism of action and clinical profile of the immunoadjuvant QS-21: a review
ConclusionThe most advanced phase III clinical applications led to the development of two vaccines containing QS-21 as part of AS, the Herpes Zoster vaccine (HZ/su) (ShingrixTM) which received a license in 2017 from the FDA and a marketing authorization in EU in 2018 and the RTS,S/AS01 vaccine (MosquirixTM) against malaria which was approved by the EMA in 2015 for further implementation in Sub Saharan countries for routine use.Graphical abstract
Source: Phytomedicine - April 1, 2019 Category: Drugs & Pharmacology Source Type: research

Perspectives Vaccines and global health: In search of a sustainable model for vaccine development and delivery
Most vaccines for diseases in low- and middle-income countries fail to be developed because of weak or absent market incentives. Conquering diseases such as tuberculosis, HIV, malaria, and Ebola, as well as illnesses caused by multidrug-resistant pathogens, requires considerable investment and a new sustainable model of vaccine development involving close collaborations between public and private sectors.
Source: Science Translational Medicine - June 18, 2019 Category: Biomedical Science Authors: Rappuoli, R., Black, S., Bloom, D. E. Tags: Perspectives Source Type: research

Antibody-Dependent, Gamma Interferon-Independent Sterilizing Immunity Induced by a Subunit Malaria Vaccine Microbial Immunity and Vaccines
In this study, we report that immunization with recombinant CSP from Plasmodium yoelii (rPyCSP), when delivered in Montanide ISA 51, induced sterilizing immunity against sporozoite challenge in C57BL/6 and BALB/c strains of mice. This immunity was antibody dependent, as evidenced by the complete loss of immunity in B-cell-knockout (KO) mice and by the ability of immune sera to neutralize sporozoite infectivity in mice. Th2-type isotype IgG1 antibody levels were associated with protective immunity. The fact that immunized gamma interferon (IFN-)-KO mice and wild-type (WT) mice have similar levels of protective immunity and ...
Source: Infection and Immunity - September 18, 2019 Category: Infectious Diseases Authors: Chawla, B., Mahajan, B., Oakley, M., Majam, V. F., Belmonte, A., Sedegah, M., Shimp, R. L., Kaslow, D. C., Kumar, S. Tags: Microbial Immunity and Vaccines Source Type: research

Overcoming challenges in the diagnosis and treatment of parasitic infectious diseases in migrants.
Authors: Norman FF, Comeche B, Chamorro S, López-Vélez R Abstract Introduction: Recent increases in population movements have created novel health challenges in many areas of the World, and health policies have been adapted accordingly in several countries. However, screening guidelines for infectious diseases are not standardized and generally do not include comprehensive screening for parasitic infections.Areas covered: Malaria, Chagas disease, leishmaniasis, amebiasis, filariases, strongyloidiasis and schistosomiasis are reviewed, focusing on the challenges posed for their diagnosis and management in vulnerabl...
Source: Expert Review of Anti-Infective Therapy - January 10, 2020 Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research