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Vaccination: Malaria Vaccine

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Total 1933 results found since Jan 2013.

Challenges and prospects for dengue and malaria control in Thailand, Southeast Asia.
Abstract Despite significant advances in the search for potential dengue vaccines and new therapeutic schemes for malaria, the control of these diseases remains difficult. In Thailand, malaria incidence is falling whereas that of dengue is rising, with an increase in the proportion of reported severe cases. In the absence of antiviral therapeutic options for acute dengue, appropriate case management reduces mortality. However, the interruption of transmission still relies on vector control measures that are currently insufficient to curtail the cycle of epidemics. Drug resistance in malaria parasites is increasing...
Source: Trends in Parasitology - November 8, 2013 Category: Parasitology Authors: Corbel V, Nosten F, Thanispong K, Luxemburger C, Kongmee M, Chareonviriyaphap T Tags: Trends Parasitol Source Type: research

Press Release Deadly Gaps Persist in New Drug Development for Neglected Diseases
This study reports a slight increase of 2.4 new products/year for 2000-2011 and predicts 4.7 new products/year through 2018. "Although strides have been made in the last decade, we still see deadly gaps in new medicines for some of the world's least visible patients," said Dr. Nathalie Strub-Wourgaft, medical director of DNDi.  "We need to get more treatment candidates, NCEs or existing ones for repurposing, into and through the R&D pipeline to fundamentally change the way we manage these diseases."   "Our patients are still waiting for true medical breakthroughs," said D...
Source: MSF News - December 3, 2013 Category: Global & Universal Source Type: news

Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7
This article is protected by copyright. All rights reserved.
Source: FEMS Microbiology Letters - December 1, 2013 Category: Microbiology Authors: Balamurugan Palanisamy, Klaus Heese Tags: Research Letter Source Type: research

Pre-Travel Preparation of US Travelers Going Abroad to Provide Humanitarian Service, Global TravEpiNet 2009-2011.
Abstract We analyzed characteristics of humanitarian service workers (HSWs) seen pre-travel at Global TravEpiNet (GTEN) practices during 2009-2011. Of 23,264 travelers, 3,663 (16%) travelers were classified as HSWs. Among HSWs, 1,269 (35%) travelers were medical workers, 1,298 (35%) travelers were non-medical service workers, and 990 (27%) travelers were missionaries. Median age was 29 years, and 63% of travelers were female. Almost one-half (49%) traveled to 1 of 10 countries; the most frequent destinations were Haiti (14%), Honduras (8%), and Kenya (6%). Over 90% of travelers were vaccinated or considered immune...
Source: The American Journal of Tropical Medicine and Hygiene - January 20, 2014 Category: Tropical Medicine Authors: Stoney RJ, Jentes ES, Sotir MJ, Kozarsky P, Rao SR, Larocque RC, Ryan ET, the Global TravEpiNet Consortium Tags: Am J Trop Med Hyg Source Type: research

Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
Abstract Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in th...
Source: Biomed Res - February 18, 2014 Category: Research Authors: Kronenberger T, Lindner J, Meissner KA, Zimbres FM, Coronado MA, Sauer FM, Schettert I, Wrenger C Tags: Biomed Res Int Source Type: research

Malaria: Hitches and Hopes.
Abstract Malaria, a devastating infectious disease caused by parasites of Plasmodium genera is transmitted from person to person through bites of infected mosquitoes. It generally traps underdeveloped nations with poor infrastructure and high population density. It has attracted considerable attention from academic institutions, pharmaceutical industries and government agencies but the efforts to eradicate this threat face a number of technical, economic, financial and institutional hurdles. In the absence of clinically proven vaccines to combat malaria,chemotherapy continues to be the best available option, altho...
Source: Mini Reviews in Medicinal Chemistry - April 28, 2014 Category: Chemistry Authors: Marella A, Verma G, Shaquiquzzaman M, Akhter M, Alam MM Tags: Mini Rev Med Chem Source Type: research

Travelers With Sickle Cell Disease
ConclusionsTravelers with SCD face considerable medical risks when traveling to developing tropical countries, including malaria, bacterial infections, hypovolemia, and sickle cell‐associated vaso‐occlusive crises. For individuals with SCD, frank counseling about the risks, vigilant preventative measures, and contingency planning for illness while abroad are necessary aspects of the pre‐travel visit.
Source: Journal of Travel Medicine - May 1, 2014 Category: Infectious Diseases Authors: Shaina M. Willen, Courtney D. Thornburg, Paul M. Lantos Tags: REVIEW Source Type: research

First controlled malaria infection trial in Africa paves way for drug and vaccine development
(Burness Communications) An international research team today reports the first-ever clinical trial demonstrating controlled malaria infection in an African nation in the modern era. The study, published online in the American Journal of Tropical Medicine and Hygiene represents a significant milestone in the search for new malaria drugs and vaccines.
Source: EurekAlert! - Infectious and Emerging Diseases - July 28, 2014 Category: Infectious Diseases Source Type: news

New malaria vaccine candidates identified
Researchers have discovered new vaccine targets that could help in the battle against malaria. Taking a new, large-scale approach to this search, researchers tested a library of proteins from the Plasmodium falciparum parasite with antibodies produced by the immune systems of a group of infected children.
Source: ScienceDaily Headlines - July 30, 2014 Category: Science Source Type: news

Rwanda: Is Long Search for Malaria Vaccine Finally Ending?
[New Times]For the last 70 years, several research projects on a potential Malaria vaccine have been launched and executed at a cost of millions of dollars, but without any breakthrough.
Source: AllAfrica News: Malaria - August 25, 2014 Category: Infectious Diseases Source Type: news

7 Steps To Ensure Ebola Doesn't Disrupt Your International Travel
Is it safe to travel? Should we cancel our long-planned family safari in Botswana? Can I get Ebola from an airplane seat? For the last two decades, I've been helping people find the best doctors, treatments and medical information -- and I've never seen the kind of health panic among clients like I do now. (Yes, No and Extraordinarily unlikely are the short answers to these questions, by the way). For expert advice, I checked in with Dr. Michael Callahan, an associate physician in the Division of Infectious Diseases at Massachusetts General Hospital/Harvard Medical School. Callahan ran one of the Department of Defense pr...
Source: Science - The Huffington Post - October 27, 2014 Category: Science Source Type: news

Malaria, Pneumonia Going Untreated Due To Ebola Outbreak
MONROVIA, Liberia (AP) — The Ebola outbreak has spawned a "silent killer," experts say: hidden cases of malaria, pneumonia, typhoid and the like that are going untreated because people in the countries hardest hit by the dreaded virus either cannot find an open clinic or are too afraid to go to one. Evidence of what the World Health Organization calls an "emergency within the emergency" is everywhere in Guinea, Liberia and Sierra Leone, the West African countries worst hit by the Ebola epidemic. It can be seen in a decline in the number of kids being vaccinated for preventable diseases. It can be seen in the mother who ...
Source: Healthy Living - The Huffington Post - November 5, 2014 Category: Consumer Health News Source Type: news

Parasite researcher wins international malaria medal
(Walter and Eliza Hall Institute) Melbourne researcher Professor Alan Cowman has won the Sornchai Looareesuwan Medal 2014 for his significant contributions to understanding how the malaria parasite causes disease and for his search for potential malaria vaccines.
Source: EurekAlert! - Medicine and Health - December 3, 2014 Category: Global & Universal Source Type: news

Global Climate Anomalies and Potential Infectious Disease Risks: 2014-2015
Conclusions Based on current global climate anomaly conditions and forecasts, El Niño is likely to develop during late 2014 and persist into early 2015. The expected effects on regional weather patterns include persistent high temperatures and drought in some areas, and heavy rainfall and flooding in others. This may enhance populations of particular vectors and the transmission of various infectious diseases in human and animal populations. Although local weather conditions mediate part of ENSO’s influence on infectious disease transmission (“teleconnections”), incorporating ENSO indicators into disease risk predic...
Source: PLOS Currents Outbreaks - January 26, 2015 Category: Epidemiology Authors: Jean-Paul Chretien Source Type: research

Kenya: After a 30-Year Search, Effective Vaccine Against Malaria in Sight
[Nation] On the afternoon of Friday, July 24, as Kenyans' excitement about the arrival of US President Barack Obama that night reached fever pitch, miles away in London, UK, a high-level scientific meeting that could greatly aid the country's war against malaria was taking place.
Source: AllAfrica News: Malaria - August 10, 2015 Category: Infectious Diseases Source Type: news