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Procedure: Anesthesia

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Total 115 results found since Jan 2013.

Exome Sequencing is a Valuable Approach in Critically Ill Patients with Suspected Monogenic Disease: Diagnosis of X-linked Centronuclear Myopathy in Preterm Twins
X-linked centronuclear myopathy (CNMX) is a severe congenital myopathy resulting from mutations in the myotubularin (MTM1) gene.1 Patients with CNMX usually present with profound weakness, muscular hypotonia, and respiratory failure in the neonatal period.2 Diagnosis is based on characteristic histopathological findings in skeletal muscle specimens from males with suggestive clinical features and the identification of supporting genetic defects.3 However, muscle biopsy requiring general anesthesia can be a high-risk procedure in premature infants or in patients with a poor general condition.
Source: Pediatrics and Neonatology - December 15, 2016 Category: Perinatology & Neonatology Authors: Jessika Johannsen, Maja Hempel, Thilo Diehl, Tobias B. Haack, Jonas Denecke Tags: Brief communication Source Type: research

Selected highlights from other veterinary journals
In this study, the authors investigated GS regulation using computer modelling, biochemical analysis of whole muscle extracts and recombinant expressed enzyme kinetics. Muscle samples were collected by open biopsy under local anaesthesia from the muscle of 12 homozygous normal (RR), 13 heterozygote...
Source: Veterinary Record - December 7, 2016 Category: Veterinary Research Tags: Research Digest Source Type: research

Biphasic cuirass ventilation for treatment of an air leak after pneumothorax in a patient with nemaline myopathy: a case report
We describe an 11-year-old boy with nemaline myopathy who developed tension pneumothorax while undergoing noninvasive positive-pressure ventilation (NIPPV). The patient developed a persistent air leak after pleurodesis with minocycline hydrochloride and lowering of the NIPPV inspiratory pressure. He required additional respiratory support without the high airway pressures that may aggravate pneumothorax. We provided adequate respiratory support without increasing the positive airway pressure using biphasic cuirass ventilation (BCV), which moved the patient ’s chest wall by negative pressure. The air leak was resolved wit...
Source: Journal of Anesthesia - September 18, 2016 Category: Anesthesiology Source Type: research

Ryanodine receptor type 3 (RYR3) as a novel gene associated with nemaline myopathy and fibre type disproportion
The ryanodine receptors (RyRs) are intracellular calcium channels with a central role in Ca2+ homeostasis. More than 300 mutations in RYR1 have been associated with a group of congenital myopathies and anaesthesia-related malignant hyperthermia. Mutations in RYR2 have been associated with cardiomyopathies. So far no disease has been associated with RYR3 mutations. The patient is a 22-year-old female, with healthy parents of Iranian descent and one healthy sister. The first signs of muscle weakness were observed at the age of 5 years, when she ran, climbed stairs and rose from the floor with difficulties.
Source: Neuromuscular Disorders - September 10, 2016 Category: Neurology Authors: Y. Nilipour, S. Nafissi, V. Varasteh, H. Hossein-Nejad, S. Tonekaboni, G. Ravenscroft, M. Oliv é, N. Laing, H. Tajsharghi Source Type: research

Repeated nonanesthetic malignant hyperthermia reactions in a child
Summary A series of life‐threatening nonanesthetic‐related MH reactions in a child was the inspiration for a proactive, novel solution allowing for early prehospital, potentially lifesaving intravenous dantrolene administration. Multidisciplinary collaboration is essential and parent education must be comprehensive and ongoing. This case underlines the importance of considering nonanesthetic MH susceptibility in the child who has a history of unspecified myopathy and who presents with fever and total body stiffness.
Source: Pediatric Anesthesia - August 25, 2016 Category: Anesthesiology Authors: Theresa Cummings, Tara Der, Cengiz Karsli Tags: Case Report Source Type: research

7th drug hypersensitivity meeting: part one
Table of contentsOral AbstractsO1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TENDaniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir PirmohamedO2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture?Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel YerlyO3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivityRebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, Davi...
Source: Clinical and Translational Allergy - August 24, 2016 Category: Allergy & Immunology Source Type: research

The Efficacy of Two Oxygen Therapy Devices (Nasal Cannula vs. Simple Mask) for Preventing Hypoxemia after General Anesthesia: A Randomized Controlled Non-Inferiority Trial of 500 Patients.
CONCLUSION: In low risk patients undergoing low risk operations, both nasal cannula or simple mask with FiO₂ = 0.35 are equally effective for preventing hypoxemia in PACU. PMID: 27501599 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - August 11, 2016 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

Anesthetic considerations for renal transplant surgery in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome: a case report
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome is a progressive syndrome with variable involvement of multiple-organ systems. These patients require special consideration for preoperative optimization, intraoperative management, and postoperative care. The medical literature regarding perioperative management of these patients relies heavily on case reports. Here we present a novel experience providing care for a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes syndrome who underwent renal transplantation for focal segmental glomerulo...
Source: Journal of Clinical Anesthesia - June 2, 2016 Category: Anesthesiology Authors: Michelle L. Humeidan, Julia Dalia, Wanye D. Traetow Tags: Case report Source Type: research

Neuromuscular Effects of Rocuronium Bromide in Patients in Statin Therapy for at least Three Months
This article is protected by copyright. All rights reserved.
Source: Basic and Clinical Pharmacology and Toxicology - May 28, 2016 Category: Drugs & Pharmacology Authors: Hongwei Ren, Huangwei Lv Tags: Original Article Source Type: research

Isolated gluteal and paravertebral muscle weakness due to anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase antibody–associated necrotizing autoimmune myopathy
Conclusions: Anti‐HMGCR–associated necrotizing autoimmune myopathy (NAM) can present in a restricted form after cessation of a statin. Biopsy of a symptomatic but uncommonly studied muscle is worthwhile. Muscle Nerve, 2016
Source: Muscle and Nerve - May 25, 2016 Category: Internal Medicine Authors: Nicole M. McGrath, Clinton P. Turner Tags: Case of the Month Source Type: research

Anaesthetic management of a patient with Pompe disease for kyphoscoliosis correction
Vaishali Kumbar, Jayashree Simha, Parameswara GundappaIndian Journal of Anaesthesia 2016 60(5):349-351Pompe disease (PD) is a type II glycogen storage disease, characterised by abnormal glycogen deposition, mainly in heart and skeletal muscles, leading to progressive loss of muscle function. The infantile variety is associated with severe hypertrophic cardiomyopathy and generally do not reach adulthood. The juvenile variety presents with progressive muscle weakness and respiratory failure. Anaesthetic management concerns in the patient reported here were mainly due to respiratory failure, myopathy and sensitivity to muscle...
Source: Indian Journal of Anaesthesia - May 2, 2016 Category: Anesthesiology Authors: Vaishali KumbarJayashree SimhaParameswara Gundappa Source Type: research

Anesthetic management of 877 pediatric patients undergoing muscle biopsy for neuromuscular disorders: a 20‐year review
ConclusionsIn this retrospective study, no patient exhibited signs or symptoms of hyperkalemia or MH probably because the incidence is very low and becomes even less likely due to the selection of the various anesthetic agents and strategies administered.
Source: Pediatric Anesthesia - April 24, 2016 Category: Anesthesiology Authors: Frederic Shapiro, Umeshkumar Athiraman, David J. Clendenin, Monica Hoagland, Navil F. Sethna Tags: Research Report Source Type: research

Isolated gluteal and paravertebral muscle weakness due to anti‐HMGCR antibody‐associated necrotizing autoimmune myopathy
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - April 6, 2016 Category: Internal Medicine Authors: Nicole M. McGrath, Clinton P. Turner Tags: Case of the Month Source Type: research

The Role of Therapeutic Drugs on Acquired Mitochondrial Toxicity.
Abstract Certain therapeutic drugs used in medical practice may trigger mitochondrial toxicity leading to a wide range of clinical symptoms including deafness, neuropathy, myopathy, hyperlactatemia, lactic acidosis, pancreatitis and lipodystrophy, among others, which could even compromise the life of the patient. The aim of this work is to review the potential mitochondrial toxicity derived from drugs used in health care, including anesthetics, antiepileptics, neuroleptics, antidepressants, antivirals, antibiotics, antifungals, antimalarics, antineoplastics, antidiabetics, hypolipemiants, antiarrhythmics, anti-inf...
Source: Current Drug Metabolism - March 21, 2016 Category: Drugs & Pharmacology Authors: Morén C, Juárez-Flores DL, Cardellach F, Garrabou G Tags: Curr Drug Metab Source Type: research