Anesthetic management of 877 pediatric patients undergoing muscle biopsy for neuromuscular disorders: a 20‐year review
ConclusionsIn this retrospective study, no patient exhibited signs or symptoms of hyperkalemia or MH probably because the incidence is very low and becomes even less likely due to the selection of the various anesthetic agents and strategies administered.
AbstractObjectiveTo investigate the possible role of serum norepinephrine (NE), leptin and 5 ‐hydroxytryptamine (5‐HT) and their correlations with sympathetic skin response located in the penis (PSSR) in primary premature ejaculation (PPE).MethodsWe compared the serum level of NE, leptin and 5 ‐HT, Intravaginal ejaculatory latency time(IELT) and The Premature Ejaculation Diagnostic Tool (PEDT) scores between 57 PPE patients and 42 healthy control men as controls, who were recruited between September 2016 and January 2019. Additionally, the amplitude and latency of PSSR were measured and compared between the two group...
This study aimed to determine the efficacy of TEAS for sedation and postoperative analgesia in lung cancer patients undergoing thoracoscopic pulmonary resection.MethodsA total of 80 patients were randomized into two groups: the TEAS group and the sham TEAS combined with general anesthesia group. Postoperative pain levels at six, 24, 48 hours, and one month after surgery were measured using the visual analogue scale (VAS). Bispectral index (BIS) score during the TEAS prior to anesthetic induction, Observer's Assessment of Alertness/Sedation (OAAS) score, sufentanil consumption during postoperative patient‐controll...
Notch signaling is a highly conserved intercellular pathway with tightly regulated and pleiotropic roles in normal tissue development and homeostasis. Dysregulated Notch signaling has also been implicated in human disease, including multiple forms of cancer, and represents an emerging therapeutic target. Successful development of such therapeutics requires a detailed understanding of potential on-target toxicities. Here, we identify autosomal dominant mutations of the canonical Notch ligand Jagged1 (or JAG1) as a cause of peripheral nerve disease in 2 unrelated families with the hereditary axonal neuropathy Charcot-Marie-T...
Our medical staff just implemented a similar policy. A couple of our surgeons were complaining about it. My group has a mandatory retirement age. EEOC Sues Yale New Haven Hospital for Age and Disability Discrimination
(Mayo Clinic) An approach based on artificial intelligence (AI) may allow EKGs to be used to screen for hypertrophic cardiomyopathy in the future. With hypertrophic cardiomyopathy, the heart walls become thick and may interfere with the heart's ability to function properly. The disease also predisposes some patients to potentially fatal abnormal rhythms. Current EKG technology has limited diagnostic yield for this disease.
ConclusionsOur neurophysiological study shows that this new 150IDE provides selective information on nociceptive system.
Genetics in Medicine, Published online: 18 February 2020; doi:10.1038/s41436-020-0754-0Spinal muscular atrophy diagnosis and carrier screening from genome sequencing data
ConclusionIn our study, both CR and PE prevented age-related changes in the corpus cavernosum of rats. Reducing nitrosative damage in the neurovascular structure was the main mechanism. CR and exercise restored the endothelial and smooth muscle cells in corpus cavernosum by decreasing apoptosis. The mechanism of enhancing functional response in corpus cavernosum with CR was the improvement of endothelial function via eNOS activation however it involves increases in the NO-cGMP signaling pathway by an endothelium-independent mechanism with PE. This might be a direct stimulation of smooth muscle cells by NO, which released f...
ConclusionsButyrate is effective in promoting peristalsis, but only when the level of colonic activity is low such as under conditions of low intraluminal pressure. This suggests that it may play a significant role in patients with poor fiber intake, where there is low mechanical stimulation in the lumen.
Vrushali PondeJournal of Anaesthesiology Clinical Pharmacology 2020 36(1):1-4
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