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Procedure: Skin Biopsy

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Total 252 results found since Jan 2013.

Hypereosinophilic syndrome due to ETV6/PDGFR-beta gene translocation - a diagnostic and therapeutic challenge.
CONCLUSION: This patient was diagnosed with a rare myeloproliferative variant of hypereosinophilic syndrome due to a t(5;12) ETV6/PDGFR-beta translocation. Imatinib mesylate, previously used successfully in syndromes associated with PDFGR-alpha mutations, showed efficacy in the context of this mutation as well. PMID: 25599554 [PubMed - indexed for MEDLINE]
Source: European Annals of Allergy and Clinical Immunology - June 4, 2015 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Familial Churg-Strauss Syndrome in a Sister and Brother.
Abstract Churg-Strauss syndrome (CSS) is a granulomatous small vessel vasculitis . It is characterized by asthma, allergic granulomatosis and vasculitis . This syndrome is rare in children. A 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. On the basis of  laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of CSS in his sister, this disease was eventually diagnosed. The patient had good response to corticosteroid.In  every  asthmatic  patient  with  prolonged  fever, eosinophilia  and  multisystemic involvment, CSS should be considered. PMID: ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Alyasin S, Khoshkhui M, Amin R Tags: Iran J Allergy Asthma Immunol Source Type: research

TG2 expressed in mast cells recruited into skin or bone marrow induces the development of pediatric mastocytosis
ConclusionThe data suggest that mast cells, recruited in the skin and BM by CCL2/CCR, may induce the development of pediatric mastocytosis through reducing IL‐10 due to up‐regulating TG2 activity via NF‐κB. Thus, TG2 may be used in diagnosis of pediatric mastocytosis, particularly SM.This article is protected by copyright. All rights reserved.
Source: Pediatric Allergy and Immunology - May 8, 2015 Category: Allergy & Immunology Authors: Young Min Ahn, Gwan Ui Hong, Sang‐Hoon Kim, Ho‐Jung Lee, Baek Heysung, Myung Nam Kim, Kui Young Park, Jai Youl Ro Tags: Original Source Type: research

Check sweat glands, hair follicles in mycosis fungoides
SAN FRANCISCO – Check for syringotropism and folliculotropism in biopsies when managing mycosis fungoides, based on data from an ongoing observational, prospective study at Thomas Jefferson University in Philadelphia. The presence of syringotropism and folliculotropism indicates the need for more...
Source: Skin and Allergy News - April 22, 2015 Category: Dermatology Tags: SAN Conference News SAN Clinical News SAN News American Academy of Dermatology Source Type: news

Urticarial vasculitis induced by OTC diet pills: a case report
Conclusion OTC diet pills are widely available worldwide, and due to its widespread use, allergologists and dermatologist should be able to recognize symptoms and lesions of cutaneous vasculitis, which may be under reported.
Source: World Allergy Organization Journal - April 16, 2015 Category: Allergy & Immunology Source Type: research

Anaphylaxis After Hymenoptera Sting: Is It Venom Allergy, A Clonal Disorder, or Both?
Publication date: Available online 7 April 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Mariana C. Castells , Jason L. Hornick , Cem Akin A 47-year-old man presented with loss of consciousness 5 minutes after being stung by a yellow jacket in his backyard. Epinephrine and fluids were required for resuscitation. Allergy evaluation revealed specific IgE to yellow jacket and honeybee, and the patient was started on venom immunotherapy. He had systemic reactions during buildup and a severe anaphylactic episode requiring 3 doses of intramuscular epinephrine at maintenance doses. Immunothe...
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 7, 2015 Category: Allergy & Immunology Source Type: research

Allergic sensitization to pegylated interferon‐α results in drug eruptions
ConclusionsOur results indicate that specific sensitizations are one cause of exanthemas under therapy with pegylated interferons. Clinical proof‐of‐concept analyses demonstrate that affected patients may benefit from a switch to conventional, non‐pegylated drugs, enabling interferon‐α therapy continuation without drug‐associated skin eruptions.This article is protected by copyright. All rights reserved.
Source: Allergy - March 31, 2015 Category: Allergy & Immunology Authors: Stephan Meller, Peter Arne Gerber, Andreas Kislat, Peter Hevezi, Thomas Göbel, Ulrike Wiesner, Sabine Kellermann, Erich Bünemann, Albert Zlotnik, Dieter Häussinger, Andreas Erhardt, Bernhard Homey Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Diagnosis of Sarcoidosis
Abstract The diagnosis of sarcoidosis, a systemic granulomatous disease, is based on a compatible clinical–radiological picture and the histological evidence of noncaseating granulomas. Other diseases mimicking sarcoidosis, mostly infections and other granulomatoses, have to be excluded. There is no single test for sarcoidosis, and the presence of granulomas alone does not establish the diagnosis. Symptoms of sarcoidosis are not specific and can be markedly different according to organ involvement and disease course. Respiratory symptoms and fatigue are the most common symptoms at any stage of disease. Histologi...
Source: Clinical Reviews in Allergy and Immunology - March 18, 2015 Category: Allergy & Immunology Source Type: research

Investigation of Patient-Specific Characteristics Associated with Treatment Outcomes for Chronic Urticaria
Conclusions Patient-specific CU characteristics associated with medication-disease control may be useful for selecting treatment regimens. A subset of CU patients remains poorly controlled that indicates an unmet need for novel therapeutic agents.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 13, 2015 Category: Allergy & Immunology Source Type: research

When is a biopsy not a biopsy?
“When I use a word, it means just what I choose it to mean…” – Humpty Dumpty Even after all these years, I’m still surprised to learn new ways the words we use every day can mean different things to patients to whom we say them. googletag.display('div-gpt-ad-cta'); Take the word “biopsy.” To a dermatologist, it means “a test of a...
Source: Skin and Allergy News - December 2, 2014 Category: Dermatology Tags: SAN Views SAN Under My Skin Source Type: news

Stevens-Johnson syndrome and toxic epidermal necrolysis.
Authors: Harr T, French LE Abstract Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but severe adverse cutaneous drug reactions that are to be considered medical emergencies. The average reported mortality rate for SJS is 1-5%, and up to 25-35% for TEN. TEN and SJS are characterized by more or less extensive painful erythematous and erosive lesions of the skin, conjunctiva and mucous membranes resulting from massive apoptosis of epithelial cells, and are considered to be two ends of a spectrum of severe epidermolytic adverse cutaneous drug reactions, differing only by their extent of sk...
Source: Chemical Immunology and Allergy - December 2, 2014 Category: Allergy & Immunology Tags: Chem Immunol Allergy Source Type: research

Positive house dust mite skin test in a nonatopic patient with scabies
A 21-year-old nonatopic man was referred for allergy evaluation with a history of an intensely pruritic eruption on his trunk and bilateral upper and lower extremities for the past 7 months. Initially, he presented to the emergency department with rectal bleeding. During the same visit, he was diagnosed as having folliculitis. He was started on oral steroids for his newly diagnosed ulcerative colitis, and subsequently the skin eruption became more widespread with more intense pruritus. A skin biopsy showed spongiotic dermatitis with possible allergic contact dermatitis.
Source: Annals of Allergy, Asthma and Immunology - December 1, 2014 Category: Allergy & Immunology Authors: Amir A. Bajoghli, Mehdi Bajoghli, Suzanne Adler Tags: Letter Source Type: research

Biopsy can underestimate diversity, aggressiveness of basal cell carcinomas
SAN DIEGO – Histology of basal cell carcinomas removed by Mohs micrographic surgery showed that presurgical biopsies had not revealed all tumor subtypes in 64% of cases, and had underestimated the aggressiveness of the tumors 24% of the time, according to data from a large, multicenter,...
Source: Skin and Allergy News - November 25, 2014 Category: Dermatology Tags: SAN Clinical News SAN News SAN SCN: Basal Cell Carcinoma ONCR News ONCR Melanoma & Skin Cancers SAN Actinic Keratosis SAN Dermatologic Surgery Source Type: news

A case of eosinophilic fasciitis presenting as pitting edema of the lower extremities.
We report a 19-year-old female who presented with pitting edema in both lower extremities. She had a history of excessive physical activity before her symptoms developed. Physical examination revealed 2+ pitting edema in both lower legs. She complained of mild pain in both knee joints and feet, with no tenderness or heating sensations. Laboratory results were unremarkable except for severe eosinophilia. Parasite infection, venous thrombosis, and cardiac and renal problems were excluded. A magnetic resonance imaging study of both lower extremities revealed increased signal intensity in the subcutaneous lesions, consistent w...
Source: Allergy, Asthma and Immunology Research - November 16, 2014 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

IgE-Mediated allergy to wheat in a child with celiac disease ¿ a case report
Conclusion: To our knowledge, this is the first report of a patient with celiac disease and concomitant IgE-mediated allergy to wheat presenting with immediate symptoms in two body systems. Although the pathophysiology of these diseases is different, this case demonstrates that they are not exclusive of one another. In patients who develop unexplained symptoms consistent with IgE-mediated allergy, an allergy assessment should be considered.
Source: Allergy, Asthma and Clinical Immunology - November 10, 2014 Category: Allergy & Immunology Authors: Tiffany WongHin KoEdmond Chan Source Type: research