Check sweat glands, hair follicles in mycosis fungoides

SAN FRANCISCO – Check for syringotropism and folliculotropism in biopsies when managing mycosis fungoides, based on data from an ongoing observational, prospective study at Thomas Jefferson University in Philadelphia. The presence of syringotropism and folliculotropism indicates the need for more...
Source: Skin and Allergy News - Category: Dermatology Tags: SAN Conference News SAN Clinical News SAN News American Academy of Dermatology Source Type: news

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Authors: Grzywnowicz M, Majsiak E, Gaweł J, Miśkiewicz K, Doniec Z, Kurzawa R Abstract Despite being clinically largely irrelevant, antibodies against cross-reactive carbohydrate determinants (CCD) are an important issue in the in vitro diagnostics, as they may produce false positive or falsely elevated results of the immunoglobulin E class (asIgE) in relation to the actually present level of asIgE. The present chapter demonstrates an effective resolution of this diagnostic issue by the use of a CCD inhibitor in in vitro tests. A synthetic CCD inhibitor, Polycheck® CCD inhibitor, was used in the laboratory di...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
ConclusionsSignificant suspicion should be raised that life saving drugs such as heparin and bivalirudin could join forces with concurrent medication acting as antigens and induce fulminant and fatal stent thrombosis as a manifestation of Kounis syndrome
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
ConclusionThis study used readily available electronic health record data to highlight comorbidities that are more common among obese pediatric patients in academic family medicine practice, thus providing information that could potentially facilitate more timely screening and intervention.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
This study is registered at ClinicalTrials.gov, number NCT02349061.FindingsBetween Oct 6, 2015, and Nov 30, 2016, 166 patients were screened, of whom 102 were randomly assigned to receive ustekinumab (n=60) or placebo (n=42). At week 24, 37 (62%) of 60 patients in the ustekinumab group and 14 (33%) of 42 patients in the placebo group achieved an SRI-4 response (percentage difference 28% [95% CI 10–47], p=0·006). Between week 0 and week 24, 47 (78%) of 60 patients in the ustekinumab group and 28 (67%) of 42 patients in the placebo group had at least one adverse event. Infections were the most common type of adv...
Source: The Lancet - Category: General Medicine Source Type: research
Publication date: Available online 21 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Javen Wunschel, Bharat Kumar
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 21 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kim Liberatore, Kevin J. KellyReduction in the prevalence of IgE-mediated allergy to latex proteins from gloves in patients may lead to lax attention by health care personnel to avoid use of latex products in latex-allergic subjects. Recent evidence from the Pennsylvania Patient Safety Reporting System shows an alarming continuation of adverse events mostly from latex urinary catheters. We are strongly advocating that health care personnel must continue to pay close attention to avoidance of lat...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
CONCLUSIONOur data suggests that our FPIES OFC protocol is safe. Early administration of IVF may prevent the development of hypotension. It is difficult to stratify risk of severe or delayed reaction based on patient characteristics and more data is needed to identify those appropriate for home introduction.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CD48 is a member of the signaling lymphocyte activation molecule family and is expressed on most hematopoietic cells (Latchman et  al., 1998). CD48 has two different ligands, CD2 and CD244, and the latter binds to CD48 with a much higher affinity (Brown et al., 1998). Through interactions with these ligands, CD48 plays important roles in immune cell function and activation, such as enhancing T-cell activation, facilitating a dhesion of antigen-presenting cells, and modulating cytotoxic T-cell and natural killer-cell immunity, which are associated with a variety of diseases including autoimmunity, allergy, infecti...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
CD48 is a member of the signaling lymphocyte activation molecule family and is expressed on most hematopoietic cells (Latchman et  al., 1998). CD48 has two different ligands, CD2 and CD244, and the latter binds to CD48 with a much higher affinity (Brown et al., 1998). Through interactions with these ligands, CD48 plays important roles in immune cell function and activation, such as enhancing T-cell activation, facilitating a dhesion of antigen-presenting cells, and modulating cytotoxic T-cell and natural killer-cell immunity, which are associated with a variety of diseases including autoimmunity, allergy, infecti...
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Letter to the Editor Source Type: research
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