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Total 140 results found since Jan 2013.

< i > Trypanosoma cruzi < /i > 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine
Conclusions/SignificanceConsidering that an early control of parasite burden and tissue damage might contribute to avoid the progression towards symptomatic forms of chronic Chagas disease, the efficacy of Tc80-based vaccines make this molecule a promising immunogen for a mono or multicomponent vaccine againstT.cruzi infection.
Source: PLoS Neglected Tropical Diseases - March 30, 2018 Category: Tropical Medicine Authors: Augusto E. Bivona Source Type: research

Danon disease: Two patients with atrial fibrillation in a single family and review of the literature.
Authors: Guo S, Zhou L, Wang R, Lv Z, Xu H, Han B, Korantzopoulos P, Hu F, Liu T Abstract The present study reports on a family with two members affected by Danon disease but having different phenotypes. The clinical manifestations of Danon disease include cardiomyopathy, skeletal myopathy and different degrees of intellectual disability that varies greatly among patients. The present case study reports on two siblings, an older sister and a younger brother, with Danon disease from an affected pedigree, presenting with distinctly different phenotypes. The sister was diagnosed with dilated cardiomyopathy at the age ...
Source: Experimental and Therapeutic Medicine - August 16, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Safety management of the treatment with antimalarial drugs in rheumatology. Interdisciplinary recommendations based on a  systematic literature search.
CONCLUSION: The updated recommendations on AM treatment in rheumatology in particular include a more rigorous measuring of doses, risk stratification in monitoring and defined ophthalmological examination methods to detect a possible retinopathy. PMID: 32095892 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - February 23, 2020 Category: Rheumatology Authors: Fiehn C, Ness T, Weseloh C, Specker C, Hadjiski D, Detert J, Krüger K, Kommission Pharmakotherapie der DGRh Tags: Z Rheumatol Source Type: research

Safety management in treatment with antimalarials in rheumatology. Interdisciplinary recommendations on the basis of a  systematic literature review.
CONCLUSION: The updated recommendations on AM treatment in rheumatology in particular include a more rigorous measuring of doses, risk stratification in monitoring and defined ophthalmological examination methods to detect a possible retinopathy. PMID: 32236844 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - March 30, 2020 Category: Rheumatology Authors: Fiehn C, Ness T, Weseloh C, Specker C, Hadjiski D, Detert J, Krüger K, DGRh Kommission Pharmakotherapie Tags: Z Rheumatol Source Type: research

The clinical and genetic heterogeneity analysis of five families with primary periodic paralysis.
Authors: Wang Q, Zhao Z, Shen H, Bing Q, Li N, Hu J Abstract To explore the clinical and genetic characteristics of five families with primary periodic paralysis (PPP). We reviewed clinical manifestations, laboratory results, electrocardiogram, electromyography, muscle biopsy, and genetic analysis from five families with PPP. Five families with PPP included: hypokalemic periodic paralysis type 1 (HypoPP1, CACNA1S, 1/5), hypokalemic periodic paralysis type 2 (HypoPP2, SCN4A, 2/5), normokalemic periodic paralysis (NormoPP, SCN4A, 1/5), and Andersen-Tawil syndrome (ATS, KCNJ2, 1/5). The basic clinical manifestations o...
Source: Channels - December 22, 2020 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

Clinical and molecular characterization of seven patients with Danon disease
Exp Ther Med. 2021 Apr;21(4):395. doi: 10.3892/etm.2021.9826. Epub 2021 Feb 24.ABSTRACTDanon disease is an X-linked glycogen storage disease characterized by skeletal myopathy, cardiomyopathy and intellectual impairment. It is caused by a loss-of-function mutation in the lysosome-associated membrane protein-2 (LAMP2) gene. In the present study, exon and boarding intron analysis of 96 cardio disease-associated genes was performed in 770 patients with hypertrophic cardiomyopathy (HCM) using second-generation sequencing. Next, the identified mutations were confirmed in family members of the patients and 300 healthy controls. ...
Source: Experimental and Therapeutic Medicine - March 8, 2021 Category: General Medicine Authors: Xuan-Ying Wang Bo Wang Xiao-Li Zhu Zhi-Ling Ma Ying Liu Chang-Hui Lei Qian-Li Yang Dan Hu Xue-Li Zhao Zhi-Rong Liu Li-Wen Liu Source Type: research

Longitudinal Observational Study of Cardiac Outcome Risk Factor Prediction in Children, Adolescents, and Adults with Barth Syndrome
AbstractBarth Syndrome (BTHS) is an X-linked mitochondrial cardioskeletal myopathy caused by defects inTAFAZZIN, a gene responsible for cardiolipin remodeling. Altered mitochondrial levels of cardiolipin lead to cardiomyopathy (CM), muscle weakness, exercise intolerance, and mortality. Cardiac risk factors predicting outcome are unknown. Therefore, we conducted a longitudinal observational study to determine risk factors for outcome in BTHS. Subjects with minimum two evaluations (or one followed by death or transplant) were included. Cardiac size, function, and QTc data were measured by echocardiography and electrocardiogr...
Source: Pediatric Cardiology - March 3, 2022 Category: Cardiology Source Type: research

Electrocardiographic features of children with Duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD) is a clinically common X-linked recessive myopathy, which is caused by mutation of the gene encoding dystrophin on chromosome Xp21. The onset of heart injury in children with ...
Source: Orphanet Journal of Rare Diseases - August 20, 2022 Category: Internal Medicine Authors: Liting Tang, Shuran Shao and Chuan Wang Tags: Review Source Type: research

The diagnostic value of serum YKL-40 for myocardial involvement in idiopathic inflammatory myopathy
CONCLUSION: Serum YKL-40 could serve as a potential biomarker to predict myocardial injury in IIM patients.PMID:36332668 | DOI:10.1016/j.cca.2022.10.022
Source: International Journal of Clinical Chemistry - November 4, 2022 Category: Chemistry Authors: Yinghong Tang Mengdi Du Wei Qian Fengyun Lu Jiayi Dai Xiaoqing Qi Wangyan Liu Changjing Feng Xiaoxuan Sun Yinsu Zhu Qiang Wang Lei Zhou Source Type: research

Multimodality Screening For (Peri)Myocarditis In Newly Diagnosed Idiopathic Inflammatory Myopathies: A Cross-Sectional Study
CONCLUSIONS: A diagnostic algorithm for detection of (peri)myocarditis in adult IIM may consist of sequential testing with high-sensitivity cardiac troponins and CMR.PMID:36683515 | DOI:10.3233/JND-221582
Source: Atherosclerosis - January 23, 2023 Category: Cardiology Authors: Johan Lim Hannah A W Walter Rianne A C M de Bruin-Bon Myrthe C Jarings R Nils Planken Wouter E M Kok Joost Raaphorst Yigal M Pinto Ahmad S Amin S Matthijs Boekholdt Anneke J van der Kooi Source Type: research

The association between C-peptide and atrial cardiomyopathy in nondiabetic adults: results from NHANES III
AbstractSerum C-peptide exhibits various biological activities. The relationship between C-peptide and atrial cardiomyopathy remains unknown. We aimed to investigate the association between C-peptide level and atrial cardiomyopathy in nondiabetic adults. Our study enrolled 4578 participants without diagnosed diabetes from the Third National Health and Nutrition Examination Survey (NHANES III). Atrial cardiomyopathy was defined as a deep terminal negative P wave in V1 below − 100 µV (more negative), according to the electrocardiogram. The participants were categorized into low C-peptide (≤ 1.46 nmol/L) and high C-...
Source: Heart and Vessels - June 24, 2023 Category: Cardiology Source Type: research