Trypanosoma cruzi 80 kDa prolyl oligopeptidase (Tc80) as a novel immunogen for Chagas disease vaccine

Conclusions/SignificanceConsidering that an early control of parasite burden and tissue damage might contribute to avoid the progression towards symptomatic forms of chronic Chagas disease, the efficacy of Tc80-based vaccines make this molecule a promising immunogen for a mono or multicomponent vaccine againstT.cruzi infection.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research

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Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the efforts to control the vector throughout the Americas, currently, there are almost seven million infected people worldwide, causing ~10,000 deaths per year, and 70 million people at risk to acquire the infection. Chagas disease treatment is restricted only to two parasiticidal drugs, benznidazole and nifurtimox, which are effective during the acute and early infections but have not been found to be as effect...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractChagas disease is caused by the parasiteTrypanosoma cruzi and transmitted mainly by triatomines and from mothers to children. In Colombia, this disease is a public health problem and due to its high endemicity and vertical transmission, women are susceptible populations that must be evaluated. Our objective was to determinate theTrypanosoma cruzi seroprevalence and factors associated with women in Pore (Municipality), Casanare, Colombia. Cross-sectional study. A sample of 230 healthy volunteer women, 15  years or older, without previous diagnosis of Chagas disease was taken; the serological analysis was done u...
Source: Journal of Parasitic Diseases - Category: Parasitology Source Type: research
Abstract Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in almost all countries of Latin America. In Brazil, oral infection is becoming the most important mechanism of transmission of the disease in several regions of the country. The gastrointestinal tract is the gateway for the parasite through this route of infection, however, little is known about the involvement of these organs related to oral route. In this sense, the present study evaluated the impact of oral infection on the digestive tract in mice infected by Berenice-78 (Be-78) T. cruzi strain, in comparison with the intraperitonea...
Source: Experimental Parasitology - Category: Parasitology Authors: Tags: Exp Parasitol Source Type: research
by Claudia Magalh ães Calvet, Tatiana Araújo Silva, Diane Thomas, Brian Suzuki, Ken Hirata, Jair Lage Siqueira-Neto, James H. McKerrow Chagas Disease, caused by the protozoan parasiteTrypanosoma cruzi, is responsible for up to 41% of the heart failures in endemic areas in South America and is an emerging infection in regions of North America, Europe, and Asia. Treatment is suboptimal due to two factors. First, the lack of an adequate biomarker to predict disease severity and response to therapy; and second, up to 120-days treatment course coupled with a significant incidence of adverse effects from the drug ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Background: American trypanosomiasis or Chagas disease represents a major health problem and continues to be endemic in large areas of Latin America. The causal agent of this emergent parasitic infectious disease is Trypanosoma cruzi. At present, the amount of infected people worldwide projected the World Health Organization sums to 8 –10 million. T. cruzi contains a major antigen, cruzipain (Cz), with an unusual C-terminal extention (C-T), retained in the mature protein. C-T bears a number of post translational modifications and is responsible for the immunogenicity of the molecule.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 0533 Source Type: research
Chagas disease (CD), caused by the parasite Trypanosoma cruzi, is endemic to parts of Mexico and Central/South America. Chagas heart disease develops in 20-30% of patients; manifestations include conduction abnormalities (e.g. right bundle branch block [RBBB]), ventricular tachycardia (VT), and progressive dilated cardiomyopathy1. The estimated prevalence of CD in the US exceeds 300,000 people2, and CD accounts for ∼19% of non-ischemic cardiomyopathy3, 7.5% of pacemakers4, and 5% of conduction abnormalities5 among Latin American immigrants in California.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Research Letter Source Type: research
CONCLUSIONS The results reinforce the recommendation that these standards be considered for performance evaluations of commercialised immunoassays and should be an integral step in the development of new test components or assay paradigms. PMID: 32725060 [PubMed - as supplied by publisher]
Source: Memorias do Instituto Oswaldo Cruz - Category: Infectious Diseases Authors: Tags: Mem Inst Oswaldo Cruz Source Type: research
CONCLUSION: These results suggest that the double or triple infection is a phenomenon existing in almost all the coendemics areas and mammals studied, which might influence the mechanisms of adaptation and pathogenicity of these parasites. PMID: 32655075 [PubMed - in process]
Source: Journal of Vector Borne Diseases - Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
Chagas disease is an endemic chronic parasitosis in Latin America affecting more than 7 million people. Around 100 million people are currently at risk of acquiring the infection; however, no effective vaccine has been developed yet. Trypanosoma cruzi is the etiological agent of this parasitosis and as an intracellular protozoan it can reside within different tissues, mainly muscle cells, evading host immunity and allowing progression towards the chronic stage of the disease. Considering this intracellular parasitism triggers strong cellular immunity that, besides being necessary to limit infection, is not sufficient to er...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Chronic human infection by the protozoan parasite Trypanosoma cruzi, known as Chagas disease, results in heart failure and death in 20 to 30% of affected individuals. Recognition and treatment of the infection are difficult. Disease control requires elimination of the vector, the reduviid bug, that infests poor quality housing in endemic areas. In South America, control has largely succeeded in the Southern Cone countries — Argentina, Chile, Uruguay, Southern Brazil and São Paulo, and Paraguay — but lags severely in the Northern Triangle (Central American) countries: El Salvador, Honduras, and Guatemala.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research
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