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Therapy: Immunotherapy
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Total 6127 results found since Jan 2013.
Heterogeneity of molecular sensitization profiles in grass pollen allergy implications for immunotherapy?
Conclusion and Clinical RelevanceMolecular allergy diagnostics is a prerequisite for future component‐resolved specific immunotherapy due to the high heterogeneity of sensitization profiles. However, of current clinical relevance is the observed correlation between the number of sensitizations and provocation test outcome.
Source: Clinical and Experimental Allergy - March 6, 2014 Category: Allergy & Immunology Authors: U. Darsow, K. Brockow, F. Pfab, T. Jakob, C. J. Petersson, M. P. Borres, J. Ring, H. Behrendt, J. Huss‐Marp Tags: Original Article‐Asthma and Rhinitis Source Type: research
Heterogeneity of molecular sensitization profiles in grass pollen allergy – implications for immunotherapy?
Conclusion and Clinical RelevanceMolecular allergy diagnostics is a prerequisite for future component‐resolved specific immunotherapy due to the high heterogeneity of sensitization profiles. However, of current clinical relevance is the observed correlation between the number of sensitizations and provocation test outcome.
Source: Clinical and Experimental Allergy - April 16, 2014 Category: Allergy & Immunology Authors: U. Darsow, K. Brockow, F. Pfab, T. Jakob, C. J. Petersson, M. P. Borres, J. Ring, H. Behrendt, J. Huss‐Marp Tags: Original Article Source Type: research
Non-adherence to subcutaneous allergen immunotherapy: inadequate health insurance coverage is the leading cause.
CONCLUSION: Of the various factors, inadequate reimbursement for allergen extract and allergy injections by health insurers is the most common reason cited for non-adherence to subcutaneous allergen immunotherapy.
PMID: 26195439 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - July 17, 2015 Category: Allergy & Immunology Authors: Vaswani R, Garg A, Parikh L, Vaswani S Tags: Ann Allergy Asthma Immunol Source Type: research
Food Allergy in childhood: phenotypes, prevention and treatment
Abstract
The prevalence of food allergy in childhood increased in the last decades, especially in Westernized countries where this phenomenon has been indicated as a second wave of the allergic epidemic. In parallel, scientific interest also increased with the effort to explain the reasons of this sudden rise and to identify potential protective and risk factors. A great attention has been focused on early exposures to allergenic foods, as well as on other nutritional factors or supplements that may influence the immune system in a positive direction. Both interventions on maternal diet before birth or during breastfeeding...
Source: Pediatric Allergy and Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Silvia Sánchez‐García, Francesca Cipriani, Giampaolo Ricci Tags: Review Article Source Type: research
Invariant natural killer cells change after an oral allergy desensitization protocol for cow's milk
Conclusions and clinical relevanceThis study confirms the efficacy and safety of CM‐OIT as well as the role of iNKT cells in CM allergy.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - July 1, 2017 Category: Allergy & Immunology Authors: Antonella Cianferoni, Rushani Saltzman, Francesca Saretta, Simona Barni, Emily Dudek, Mary Kelleher, Jonathan M. Spergel Tags: Original Article ‐Clinical Mechanisms in Allergic Disease Source Type: research
EAACI Guidelines on Allergen Immunotherapy: IgE ‐mediated Food Allergy
This article is protected by copyright. All rights reserved.
Source: Allergy - September 27, 2017 Category: Allergy & Immunology Authors: Giovanni B. Pajno, Montserrat Fernandez ‐Rivas, Stefania Arasi, Graham Roberts, Cezmi A. Akdis, Montserrat Alvaro‐Lozano, Kirsten Beyer, Carsten Bindslev‐Jensen, Wesley Burks, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Kari C. Nadeau, Lars K Tags: Position Paper Source Type: research
Low-Dose Oral Immunotherapy Using Low-Egg-Allergen Cookies for Severe Egg-Allergic Children Reduces Allergy Severity and Affects Allergen-Specific Antibodies in Serum
Conclusion: Our findings suggest that low-dose OIT using LAC is an effective and safe treatment for patients with severe egg allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 12, 2018 Category: Allergy & Immunology Source Type: research
Oral and Sublingual Immunotherapy for Treatment of IgE-Mediated Food Allergy
AbstractDevelopment of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OI...
Source: Clinical Reviews in Allergy and Immunology - April 14, 2018 Category: Allergy & Immunology Source Type: research
Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument
AbstractOral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow ’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy. While it has been shown that children who tolerate baked forms of egg and milk are more likely to deve...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research
Coated microneedle-based cutaneous immunotherapy prevents Der p 1 –induced airway allergy in mice
Allergies are increasing worldwide, and millions of persons are struggling against a host of airway allergens.1 Allergen-specific immunotherapy is the primary approach to cure allergies. However, allergen-specific immunotherapy is performed only after allergy symptoms have manifested in patients. A true mode of allergy vaccination in the form of “preventive immunotherapy” like that of infectious disease vaccination could be used to stop the allergy epidemic. Prevention of allergy onset in healthy subjects is called “primary prevention,” and prevention in subjects who are already sens itized but have yet to develo...
Source: Journal of Allergy and Clinical Immunology - August 29, 2018 Category: Allergy & Immunology Authors: Akhilesh Kumar Shakya, Chang Hyun Lee, Harvinder Singh Gill Tags: Letter to the Editor Source Type: research
Debates in Allergy Medicine: Oral immunotherapy shortens the duration of milk and egg allergy - the con argument
AbstractOral immunotherapy (OIT) has been shown to be effective for inducing desensitization in children with cow ’s milk and egg allergy. In contrast, there is limited evidence that OIT can induce tolerance or sustained unresponsiveness in food allergic patients. Sustained unresponsiveness, determined by a food challenge following a period of secondary avoidance, has been suggested to reflect a more enduring state of tolerance and is pertinent when considering the ability of OIT to shorten the duration of food allergy. While it has been shown that children who tolerate baked forms of egg and milk are more likely to deve...
Source: World Allergy Organization Journal - June 15, 2018 Category: Allergy & Immunology Source Type: research
IgE-Mediated Food Allergy
AbstractFood allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non...
Source: Clinical Reviews in Allergy and Immunology - October 29, 2018 Category: Allergy & Immunology Source Type: research
Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thomas B. Casale, Tmirah Haselkorn, Christina E. Ciaccio, Panida Sriaroon, Bradley E. ChippsAbstractCurrently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic pu...
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 15, 2018 Category: Allergy & Immunology Source Type: research
Sublingual and Patch Immunotherapy for Food Allergy.
This article reviews research advances for sublingual and patch immunotherapy for food allergy with a focus on peanut allergy. Published studies on sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT) were summarized in this review. Sublingual and epicutaneous methods have emerged as alternatives to oral immunotherapy. SLIT studies have shown modest desensitization with a robust safety profile. EPIT studies have high adherence rates, an excellent safety profile, and potential for desensitization in children. Advances in food immunotherapy with SLIT and EPIT studies have shown promise as viable alternatives...
Source: The Medical Clinics of North America - November 27, 2019 Category: General Medicine Authors: Waldron J, Kim EH Tags: Immunol Allergy Clin North Am Source Type: research
Precision medicine in cow's milk allergy
Purpose of review
The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy.
Recent findings
The development of ‘omics’ sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and significant advances in the knowledge of the pathogenesis and mechanisms of cow's milk allergy. Omics-based technologies allow the practitioner to better differentiate cow's milk allergy subtypes and to predict cow's milk allergy (CMA) persistence over time. Precision medicine extends the role of the or...
Source: Current Opinion in Allergy and Clinical Immunology - May 1, 2020 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research
