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Therapy: Steroid Therapy

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Total 83 results found since Jan 2013.

Clinical, Endoscopic and Histopathological Characteristics of Pediatric Patients with Eosinophilic Digestives Diseases attending the Gastroenterology Department of the National Institute Of Pediatrics in Mexico City
The objective of this study was to describe the clinical and paraclinical profile of pediatris patients with EDD.
Source: Journal of Allergy and Clinical Immunology - February 1, 2018 Category: Allergy & Immunology Authors: Amyra Ali Azamar Jacome, Josefina Monserrat Cazares Mendez, David Alejandro Mendoza Hernandez, Jose G. Huerta Lopez Source Type: research

The Immunologic Paradoxes of IgG4-Related Disease
AbstractIgG4-related disease (IgG4-RD), which usually occurs in middle-aged and elderly men, is a newly recognized fibroinflammatory condition characterized by swelling and sclerosis of involved organs, increased IgG4-positive plasma cell infiltration in lesions, and elevated IgG4 concentration in serum. Despite growing interest in the research, the pathophysiological mechanism remains elusive. Most IgG4-RD patients respond well to steroid therapy initially, but recurrent and refractory cases are common, especially in advanced fibrotic stage. Recent studies have documented the heterogeneity of the B cell lineages, which su...
Source: Clinical Reviews in Allergy and Immunology - February 19, 2018 Category: Allergy & Immunology Source Type: research

On-demand intermittent beclomethasone is effective for mild asthma in Brazil
ConclusionClinicians might consider intermittent inhaled steroid therapy as a therapeutic regimen for mild persistent asthma.Trial registration The Portuguese and English versions of the study protocol were submitted, approved, and registered in the Brazilian Network Platform for Clinical Trials (http://www.ensaiosclinicos.gov.br) under the primary identifier number “RBR-3gbyhk”. This platform is part of the Primary Registries in the World Health Organization Registry Network, where the trial is registered under the following Universal Trial Number: 1111-1149-4774
Source: Clinical and Translational Allergy - March 5, 2018 Category: Allergy & Immunology Source Type: research

Pediatric eosinophilic esophagitis: updates for the primary care setting
Purpose of review Eosinophilic esophagitis (EoE) is a multifactorial, non-IgE-mediated inflammatory disorder of the esophagus and is the most common cause of food impaction in the pediatric population. The purpose of this review is to describe the current recommendations for diagnosis and management of EoE. Recent findings New data has associated EoE with other allergic disorders of the atopic march as well as several risk factors, which predispose to allergic conditions. A subset of patients with esophageal eosinophilia respond to proton pump inhibitor (PPI) therapy with a partial or complete resolution of esophageal...
Source: Current Opinion in Pediatrics - November 10, 2018 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Henry H. Bernstein Source Type: research

Multiphasic treatment modality for pediatric eosinophilic gastroenteritis, a single center experience
Treatment of eosinophilic gastroenteritis (EG) in pediatrics is challenging. Options available include systemic immune modulators as well as targeted dietary restriction. Both regimens are difficult to adhere to given the adverse effects of systemic steroid therapy and compliance difficulties with diet restriction. At our institution we have found that only 25% of patients with EG respond to diet restriction. Here we describe the presentation and outcome of pediatric EG patients placed on a unique multiphasic steroid treatment.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2018 Category: Allergy & Immunology Authors: K. Kennedy, M. Ruffner, A. Muir Tags: P403 Source Type: research

Pediatric eosinophilic esophagitis: updates for the primary care setting
Purpose of review Eosinophilic esophagitis (EoE) is a multifactorial, non-IgE-mediated inflammatory disorder of the esophagus and is the most common cause of food impaction in the pediatric population. The purpose of this review is to describe the current recommendations for diagnosis and management of EoE. Recent findings New data has associated EoE with other allergic disorders of the atopic march as well as several risk factors, which predispose to allergic conditions. A subset of patients with esophageal eosinophilia respond to proton pump inhibitor (PPI) therapy with a partial or complete resolution of esophageal...
Source: Current Opinion in Pediatrics - December 1, 2018 Category: Pediatrics Tags: ALLERGY, IMMUNOLOGY AND RELATED DISORDERS: Edited by Jordan S. Orange Source Type: research

Phase 1 clinical study to assess the safety of a novel drug delivery system providing long ‐term topical steroid therapy for chronic rhinosinusitis
ConclusionLYR ‐210 is safe and well‐tolerated in ESS‐naive CRS patients and leads to sustained symptom improvement in patients.
Source: International Forum of Allergy and Rhinology - January 15, 2019 Category: Allergy & Immunology Authors: Richard G. Douglas, Alkis J. Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

The neuroplastic effect of olfactory training to the recovery of olfactory system in mouse model
ConclusionOT improved olfactory function, as indicated by the food ‐finding test. OT improved the olfactory recovery time to stimulate olfactory nerve regeneration. OT may initially stimulate the olfactory receptor, followed by neurogenesis. Steroid therapy and OT operated under completely different mechanisms in the upregulated gene study. These results indicate that OT may be one of the future modalities for treating olfactory impairment.
Source: International Forum of Allergy and Rhinology - February 21, 2019 Category: Allergy & Immunology Authors: Boo ‐Young Kim, Ju Yeon Park, Eui Jin Kim, Byung Guk Kim, Sung Won Kim, Soo Whan Kim Tags: ORIGINAL ARTICLE Source Type: research

Ketogenic Diet as a Treatment for Super-Refractory Status Epilepticus in Febrile Infection-Related Epilepsy Syndrome
Conclusions: The characteristic EEG pattern in the acute phase promoted timely diagnosis of FIRES. Our data suggest that KD may be a safe and promising therapy for FIRES with SRSE, and that early initiation of KD produces a favorable prognosis. Therefore, KD should be applied earlier in the course of FIRES. Intravenous KD can be an effective alternative route of administration for patients who may not take KD enterally. Introduction Febrile infection-related epilepsy syndrome (FIRES) is a rare epileptic encephalopathy of unknown etiology which occurs in patients without active epilepsy or underlying neurological diso...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Phase 1 clinical study to assess the safety of a novel drug delivery system providing long ‐term topical steroid therapy for chronic rhinosinusitis
ConclusionLYR ‐210 is safe and well‐tolerated in ESS‐naive CRS patients and leads to sustained symptom improvement in patients.
Source: International Forum of Allergy and Rhinology - March 27, 2019 Category: Allergy & Immunology Authors: Richard G. Douglas, Alkis J. Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang Tags: ORIGINAL ARTICLE Source Type: research

The neuroplastic effect of olfactory training to the recovery of olfactory system in mouse model
ConclusionOT improved olfactory function, as indicated by the food ‐finding test. OT improved the olfactory recovery time to stimulate olfactory nerve regeneration. OT may initially stimulate the olfactory receptor, followed by neurogenesis. Steroid therapy and OT operated under completely different mechanisms in the upregulated gene study. These results indicate that OT may be one of the future modalities for treating olfactory impairment.
Source: International Forum of Allergy and Rhinology - February 20, 2019 Category: Allergy & Immunology Authors: Boo ‐Young Kim, Ju Yeon Park, Eui Jin Kim, Byung Guk Kim, Sung Won Kim, Soo Whan Kim Tags: ORIGINAL ARTICLE Source Type: research

Immunologic Adverse Effects of Biologics for the Treatment of Atopy
AbstractThe use of biologic agents as therapies for atopic diseases such as asthma and atopic dermatitis has increased greatly in recent years. The biological agents used to treat atopic diseases are for the most part monoclonal antibodies that suppress the immune response and reduce inflammation by targeting particular cytokines or other molecules involved in Th1, Th2, or Th17 immune reactions. Various side effects and rare complications have been reported from these agents. In this review, we discuss mechanisms of various adverse effects for the biologic agents currently in use or in development for atopic and inflammato...
Source: Clinical Reviews in Allergy and Immunology - July 12, 2019 Category: Allergy & Immunology Source Type: research

Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis
Purpose of review Pathogenesis of nasal polyp has been largely studied based on innate and adaptive immunity of sinonasal mucosa. So far, various factors have been identified that trigger an inflammatory response in the pathogenesis of nasal polyps. In this review, we summarized recently updated information in the understanding of mechanisms in the development of chronic rhinosinusitis with nasal polyp (CRSwNP) focusing on Th2 inflammation. Recent findings Endotype of CRSwNP presented mainly Th2-skewed inflammation, and it has been associated with refractoriness and comorbidities. Staphylococcus aureus can drive Th2 i...
Source: Current Opinion in Allergy and Clinical Immunology - January 3, 2020 Category: Allergy & Immunology Tags: RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner Source Type: research

Unexpected effects of systemic steroids on the CRSwNP proteome: is protein upregulation more important than inhibition?
ConclusionProteomic analysis of differentially expressed proteins in CRSwNP demonstrates that systemic steroids cause almost uniform upregulation of transcriptionally decreased proteins, whereas the effects of steroids on transcriptionally increased proteins are more heterogeneous. Thus, proteomic analysis may be an effective tool to understand specific therapeutic benefits of steroid use in polyp disease and to create more targeted treatments.
Source: International Forum of Allergy and Rhinology - February 5, 2020 Category: Allergy & Immunology Authors: Alan D. Workman, Michelle M. Miyake, Angela L. Nocera, Sarina K. Mueller, Kristen Finn, Hasan H. Otu, Towia A. Libermann, Benjamin S. Bleier Tags: ORIGINAL ARTICLE Source Type: research

Asthma Patients: Stay on Steroids in Face of COVID-19, Say Experts Asthma Patients: Stay on Steroids in Face of COVID-19, Say Experts
Patients with asthma should stay on their preventive steroid therapy, both to protect against infection with COVID-19 as well as if they succumb to the virus, say experts in respiratory medicine.Medscape Medical News
Source: Medscape Allergy Headlines - March 20, 2020 Category: Allergy & Immunology Tags: Pulmonary Medicine News Source Type: news