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Total 1303 results found since Jan 2013.

The effect of Candida albicans systemic infection on matrix metalloproteinases in breast cancer bearing BALB/c mice.
Abstract Breast cancer patients are susceptible to infections such as candidiasis. Due to the importance and the role of matrix metalloproteinases (MMP) in breast cancer progression and its correlation with tumor metastasis, we analyzed the serum level of MMPs -2, -3, -9 and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in breast cancer bearing mice in the presence of systemic Candida albicans infection. Female BALB/c mice were divided into 4 groups: group I had tumor + candidiasis; group II, tumor only; group III, candidiasis only and group IV as negative control. Tumor tissue was separated from stock b...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 1, 2013 Category: Allergy & Immunology Authors: Hajari Taheri F, Seyedolmohadesin M, Bayat M, Mahdavi M, Yazdi MH, Eslamifar A, Abolhasani M Tags: Iran J Allergy Asthma Immunol Source Type: research

The Risk of Progressive Multifocal Leukoencephalopathy Under Biological Agents Used in the Treatment of Chronic Inflammatory Diseases.
Abstract Biological agents such as monoclonal antibodies and soluble cytokine receptors have taken on an expanding role in the treatment of chronic immune mediated diseases. Progressive multifocal leukoencephalopathy (PML) is a rare central neurological disease caused by JC virus infection that has been described in the setting of conditions with severe impairment of immune surveillance, such as haematological malignancies, stem cell or solid organ transplantation and AIDS. This serious demyelinating disease has recently been described in patients receiving monoclonal antibodies for chronic inflammatory diseases s...
Source: Inflammation and Allergy Drug Targets - February 23, 2014 Category: Allergy & Immunology Authors: Toussirot E, Bereau M Tags: Inflamm Allergy Drug Targets Source Type: research

The Gut Microbiome.
Abstract Since the discovery and use of the microscope in the 17th century, we know that we host trillions of micro-organisms mostly in the form of bacteria indwelling the "barrier organs" skin, gut, and airways. They exert regulatory functions, are in a continuous dialogue with the intestinal epithelia, influence energy handling, produce nutrients, and may cause diabetes and obesity. The human microbiome has developed by modulating or avoiding inflammatory responses; the host senses bacterial presence through cell surface sensors (the Toll-like receptors) as well as by refining mucous barriers as passive defense ...
Source: Inflammation and Allergy Drug Targets - June 23, 2014 Category: Allergy & Immunology Authors: Actis GC Tags: Inflamm Allergy Drug Targets Source Type: research

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in pediatric liver transplant patients
ConclusionsLT has an impact on humoral immunity, remarkably in those patients developing FA.The increase in serum markers of mucosal IgA, food allergen specific IgA and cTfh cells observed in LTFA, point towards a disturbance in intestinal immune homeostasis in this patient group.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - February 1, 2015 Category: Allergy & Immunology Authors: Ruth De Bruyne, Philippe Gevaert, Myriam Van Winckel, Natalie De Ruyck, Aurelie Minne, Delfien Bogaert, Stephanie Van Biervliet, Saskia Vande VeldeD, Francoise Smets, Etienne Sokal, Fréderic Gottrand, Jérémy Vanhelst, Bruno Detry, Charles Pilette, Bart Tags: Original Article‐Clinical Mechanisms in Allergic Disease Source Type: research

Evaluation of the Effect of Ascorbic Acid Administration on Gene Expression Level of IL-6 and TNF-α Cytokines in Deceased Donors.
Abstract Brain death is associated with increased inflammatory cytokines levels and poor graft quality to transplant. We aimed to evaluate the impact of Ascorbic Acid (AA) on the inflammatory status of Brain-Dead Donors (BDDs). Forty BDDs were randomly divided into two groups. Donor treatment (n=20) consisted of 100 mg/kg AA infusion 6 hours before donor operation and subsequent infusion of 100 mg/kg/p6h until organ removal. Blood samples were taken at three times, 6 hours before donor surgery (TP1), immediately after laparotomy (TP2), and before organ removal (TP3). Gene expression level and serum concentration o...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 18, 2015 Category: Allergy & Immunology Authors: Kazemi M, Tabei SM, Najafizadeh K, Mehrabi Sisakht J, Milani S, Khosravi MB Tags: Iran J Allergy Asthma Immunol Source Type: research

Management of acquired peanut allergy following solid-organ transplant
Publication date: Available online 22 April 2015 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Carolyn Word , Erin Klaffky , Christina Ortiz , Thamiris Palacios , Shawn Pelletier , Walter Oliveira , Barbara Greb , Lisa Workman , Thomas Platts-Mills , Julia Wisniewski
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 4, 2015 Category: Allergy & Immunology Source Type: research

Tacrolimus use in renal and cardiac pediatric transplantation: no increased risk of food allergies.
PMID: 26094803 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - June 18, 2015 Category: Allergy & Immunology Authors: Graham F, Racicot F, Jamali L, Cong VP, Raboisson MJ, Paradis J, Paradis L, Des Roches A Tags: Ann Allergy Asthma Immunol Source Type: research

In Vitro Generation of IL-35-expressing Human Wharton's Jelly-derived Mesenchymal Stem Cells Using Lentiviral Vector.
Abstract Human Wharton's Jelly-derived Mesenchymal Stem Cells (hWJ-MSCs) are easily available cells without transplant rejection problems or ethical concerns compared to bone-marrow-derived MSCs for prospective clinical applications. These cells display immunosuppressive properties and may be able to play an important role in autoimmune disorders. Regulatory T-cells (Treg) are important to prevent autoimmune disease development. Interleukin 35 (IL-35) induces the proliferation of Treg cell populations and reduces the activity of T helper 17 (Th17) and T helper 1 (Th1) cells, which play a central role in initiation...
Source: Iranian Journal of Allergy, Asthma and Immunology - August 1, 2015 Category: Allergy & Immunology Authors: Amari A, Ebtekar M, Moazzeni S, Soleimani M, Mohammadi-Amirabad L, Tahoori M, Massumi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Altered Expression of MicroRNAs Following Chronic Allograft Dysfunction with Interstitial Fibrosis and Tubular Atrophy.
In this study, biopsy and PBMC samples of 16 CAD with IFTA and 17 normal allografts (NA) were collected. Using Taqman MicroRNA Assays the expression levels of miR-142-5p, miR-142-3p and miR-211 were determined in two groups. Our results showed that miR-142-5p and miR-142-3p were significantly (p<0.0001) up-regulated and miR-211 was significantly (p<0.0001) down-regulated in renal allograft tissues of CAD with IFTA compared with NA recipients. Moreover, miR-142-3p and miR-211 were significantly (p<0.0001) up-regulated and down-regulated respectively in PBMC samples of CAD with IFTA. According to the ROC curve analy...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 1, 2015 Category: Allergy & Immunology Authors: Soltaninejad E, Nicknam MH, Nafar M, Sharbafi MH, Keshavarz Shahbaz S, Barabadi M, Yekaninejad MS, Bahrami T, Ahmadpoor P, Amirzargar A Tags: Iran J Allergy Asthma Immunol Source Type: research

Neuroprotective Effects of Transplanted Mesenchymal Stromal Cells-derived Human Umbilical Cord Blood Neural Progenitor Cells in EAE.
Abstract Multiple Sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system. The aim of this study was to investigate the neuroprotective effects of transplanted human umbilical cord blood mesenchymal stromal cells (UCB-MSC) derived neural progenitor cell (MDNPC) in EAE, an experimental model of MS. To initiate neuronal differentiation of UCB-MSCs, the pre-induction medium was removed and replaced with induction media containing retinoic acid, b FGF, h EGF, NGF, IBMX and ascorbic acid for one week. The expression of neural genes was examined in comparison to control group b...
Source: Iranian Journal of Allergy, Asthma and Immunology - November 1, 2015 Category: Allergy & Immunology Authors: Rafieemehr H, Kheyrandish M, Soleimani M Tags: Iran J Allergy Asthma Immunol Source Type: research

A severe case of minocycline-induced DRESS resulting in liver transplantation and autoimmune sequelae.
PMID: 26782675 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - January 9, 2016 Category: Allergy & Immunology Authors: Lan J, Lahoti A, Lew DB Tags: Ann Allergy Asthma Immunol Source Type: research

Microbiome Regulation of Autoimmune, Gut and Liver associated Diseases.
Abstract Extensive analysis of the complexity and diversity of microbiota using metagenomics in the gut and other body sites has provided evidence that dysbiosis occurs in many disease states. With the application of next generation sequencing technology this research is starting to uncover the impact of microbiota on metabolic, physiological and immunological pathways and elucidate the cellular and molecular mechanisms involved. To highlight these advances we have focused on autoimmunity and gut and liver related diseases and discuss the opportunities and challenges of translating microbiome research towards its ...
Source: Inflammation and Allergy Drug Targets - January 28, 2016 Category: Allergy & Immunology Authors: Singh B Tags: Inflamm Allergy Drug Targets Source Type: research

Laronidase desensitization during stem cell transplant in a child with Hurler syndrome.
PMID: 26916445 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - February 23, 2016 Category: Allergy & Immunology Authors: Rosenberg J, Jhaveri P, Kelbel T Tags: Ann Allergy Asthma Immunol Source Type: research

Desensitization to Mycofenolate Mofetil: a novel 12 step protocol.
We report a successful desensitization to MMF in a double heart-kidney transplant recipient. PMID: 27425171 [PubMed - in process]
Source: European Annals of Allergy and Clinical Immunology - July 20, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases
There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF- α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors.
Source: Journal of Allergy and Clinical Immunology - August 27, 2016 Category: Allergy & Immunology Authors: M übeccel Akdis, Alar Aab, Can Altunbulakli, Kursat Azkur, Rita A. Costa, Reto Crameri, Su Duan, Thomas Eiwegger, Andrzej Eljaszewicz, Ruth Ferstl, Remo Frei, Mattia Garbani, Anna Globinska, Lena Hess, Carly Huitema, Terufumi Kubo, Zsolt Komlosi, Patrici Tags: Fundamentals of allergy and immunology Source Type: research