The Gut Microbiome.

The Gut Microbiome.
Inflamm Allergy Drug Targets. 2014 Jun 23;
Authors: Actis GC
Abstract
Since the discovery and use of the microscope in the 17th century, we know that we host trillions of micro-organisms mostly in the form of bacteria indwelling the "barrier organs" skin, gut, and airways. They exert regulatory functions, are in a continuous dialogue with the intestinal epithelia, influence energy handling, produce nutrients, and may cause diabetes and obesity. The human microbiome has developed by modulating or avoiding inflammatory responses; the host senses bacterial presence through cell surface sensors (the Toll-like receptors) as well as by refining mucous barriers as passive defense mechanisms. The cell density and composition of the microbiome are variable and multifactored . The way of delivery establishes the type of initial flora ; use of antibiotics is another factor; diet composition after weaning will shape the adult's microbiome composition, depending on the subject's life-style. Short-chain fatty acids participate in the favoring action exerted by microbiome in the pathogenesis of type-2 diabetes and obesity. Clinical observation has pinpointed a sharp rise of various dysimmune conditions in the last decades, including IBD and rheumatoid arthritis, changes that outweigh the input of simple heritability. It is nowadays proposed that the microbiome, incapable to keep up with the changes of our life-style and feeding ...

Source: Inflammation and Allergy Drug Targets - June 23, 2014 Category: Allergy & Immunology Authors: Actis GC Tags: Inflamm Allergy Drug Targets Source Type: research