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Procedure: Skin Biopsy

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Total 252 results found since Jan 2013.

Familial Churg-Strauss Syndrome in a Sister and Brother.
Abstract Churg-Strauss syndrome (CSS) is a granulomatous small vessel vasculitis . It is characterized by asthma, allergic granulomatosis and vasculitis . This syndrome is rare in children. A 5 years old boy was admitted with cough, fever and dyspnea for 2 weeks. On the basis of  laboratory data (peripheral eosinophilia), associated with skin biopsy, and history of CSS in his sister, this disease was eventually diagnosed. The patient had good response to corticosteroid.In  every  asthmatic  patient  with  prolonged  fever, eosinophilia  and  multisystemic involvment, CSS should be considered. PMID: ...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2015 Category: Allergy & Immunology Authors: Alyasin S, Khoshkhui M, Amin R Tags: Iran J Allergy Asthma Immunol Source Type: research

Association of TG2 from mast cells and chronic spontaneous urticaria pathogenesis.
CONCLUSION: Our findings suggest that TG2 expressed in and released from mast cells plays an important role in CSU pathogenesis. PMID: 27613463 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - August 31, 2016 Category: Allergy & Immunology Authors: Hong GU, Ro JY, Bae Y, Kwon IH, Park GH, Choi YH, Choi JH Tags: Ann Allergy Asthma Immunol Source Type: research

Downregulation of Aquaporin3 in Systemic Sclerosis Dermal Fibroblasts.
Abstract Skin dryness and thickening are hallmarks of systemic sclerosis (SSc) disease. Aquaporins (AQPs) are plasma membrane proteins that transport glycerol and water, resulting in water retention and skin hydration. Expression of AQPs has been evaluated in human normal skin. However, expression of these proteins in SSc dermal fibroblasts has not yet been reported. The aim of this study was to assess the expression profile of AQPs in dermal fibroblasts of SSc patients. Fibroblast cells were extracted from SSc and healthy skin biopsies and characterized using fibroblast surface protein antibody. The SYBR Green Re...
Source: Iranian Journal of Allergy, Asthma and Immunology - June 1, 2017 Category: Allergy & Immunology Authors: Yousefi B, Mahmoudi M, Sarafnejad A, Karimizadeh E, Farhadi E, Jamshidi AR, Kavosi H, Aslani S, Gharibdoost F Tags: Iran J Allergy Asthma Immunol Source Type: research

Acute cardiac disease in a patient with hyper-IgE syndrome.
We describe the case of a 24-year-old male with hyper-IgE syndrome (HIES) which was diagnosed at 4 years of age and died from a very rare cardiac complication. He had typical clinical and laboratory manifestations of HIES, including total serum IgE as high as > 100,000 IU/mL. Stem cell transplantation was not available. During the 20-year follow-up, he suffered numerous various infections of the skin and deep organs, partial lung resection, as well as multiple bone fractures. At age 24, he developed acute decompensated heart failure associated with elevated serum troponin I and brain natriuretic protein. Two-dimensional...
Source: European Annals of Allergy and Clinical Immunology - September 9, 2017 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Schnitzler syndrome with IgG gammopathy and elevated IL-1 β and IL-17 in skin biopsy.
Schnitzler syndrome with IgG gammopathy and elevated IL-1β and IL-17 in skin biopsy. Ann Allergy Asthma Immunol. 2017 Nov 18;: Authors: Villarreal RS, VandenBoom T, Gonzalez-Gonzalez FJ, Carter RG, Peters NT, Peters AT, Chiarella SE PMID: 29162318 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - November 18, 2017 Category: Allergy & Immunology Authors: Villarreal RS, VandenBoom T, Gonzalez-Gonzalez FJ, Carter RG, Peters NT, Peters AT, Chiarella SE Tags: Ann Allergy Asthma Immunol Source Type: research

Downregulation of miR-542-3p Contributes to Apoptosis Resistance in Dermal Fibroblasts from Systemic Sclerosis Patients via Survivin Overexpression.
Abstract Systemic sclerosis (SSc) is characterized by excessive production of collagens by fibroblasts that leads to vast fibrosis. Resistance to apoptosis is one of the possible underlying mechanisms of fibrosis in these patients. Survivinis involved in inhibition of apoptosis and aberrantly functions in SSc. Since dysregulation of survivin-targeting microRNAs (miRNAs) has frequently been observed in cancer and some autoimmune disorders, this study aimed to investigate their expression status in dermal fibroblasts from SSc patients. DiffuseSSc patients were selected according to American College of Rheumatology c...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 31, 2019 Category: Allergy & Immunology Authors: Vahidi Manesh P, Farazmand A, Gharibdoost F, Vanaki N, Mostafaei S, Kavosi H, Mahmoudi MB, Mahmoudi M Tags: Iran J Allergy Asthma Immunol Source Type: research

Familial clustering of hypereosinophilic diseases treated with mepolizumab: a case report from Japan.
We describe a female diagnosed with non-allergic asthma. On March 24, 2016, examination of the skin-biopsy specimen revealed dense eosinophilic infiltration, and the Fip-1-like 1-platelet-derived growth factor receptor a fusion gene in peripheral blood mononuclear cells was negative. She was diagnosed with idiopathic hypereosinophilic syndrome. She was treated with intravenous methylprednisolone (MPSL), and subsequent oral MPSL. Then, she started to receive a monthly mepolizumab in June 2016, and successfully withdrew from daily use of oral MPSL. The patient has a mother diagnosed with non-allergic asthma. In February 2005...
Source: European Annals of Allergy and Clinical Immunology - October 10, 2019 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

A Case of Linear IgA Bullous Dermatosis Induced by Aspirin Therapy.
Abstract Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disease that may be triggered by some diseases and medications. For the latter one, non-steroidal anti-inflammatory drugs (NSAIDs) have been identified as one of the potential causative agents to develop LABD. Here, a rare case of drug-induced LABD is introduced. A 13-month-old Iranian boy presented with a history of generalized blisters, displaying the classic "string of pearls" sign who was eventually diagnosed as a case of LABD. In his admission, he was diagnosed whit Mucocutaneous lymph node syndrome and treated with aspirin.  Some ...
Source: Iranian Journal of Allergy, Asthma and Immunology - October 18, 2020 Category: Allergy & Immunology Authors: Nabavi M, Rezaeifar A, Sadeghinia A, Arshi S, Bahrami S, Bemanian MH, Fallahpour M, Shokri S, Vakilazad Z Tags: Iran J Allergy Asthma Immunol Source Type: research

Guidelines on Diagnosis and Management of Cow's Milk Protein Allergy.
Abstract JUSTIFICATION: Cow's milk protein allergy (CMPA) is increasingly being diagnosed in the West, while there is scant data on the subject from India. There is low awareness among pediatricians about its diagnosis and management; leading to improper diagnosis. PROCESS: A group of experts from the pediatric gastroenterology sub-specialty chapter of Indian Academy of Pediatrics (Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition) met at Mumbai on 26 October, 2018 and discussed various issues relating to the subject. A broad consensus was reached and a writing committee was formed. They ...
Source: Indian Pediatrics - August 14, 2020 Category: Pediatrics Authors: Matthai J, Sathiasekharan M, Poddar U, Sibal A, Srivastava A, Waikar Y, Malik R, Ray G, Geetha S, Yachha SK, Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition; Pediatric Gastroenterology Chapter of Indian Academy of Pediatrics Tags: Indian Pediatr Source Type: research

Drug-induced exanthems: Correlation of allergy testing with histologic diagnosis
Conclusions: Dermatopathologic evaluation of skin biopsy specimens is of limited use in differentiating between DIE and NDIE. All efforts should be made to subject these patients to thorough allergy testing for definitely confirming or ruling out drug hypersensitivity.
Source: Journal of the American Academy of Dermatology - August 8, 2013 Category: Dermatology Authors: Cornelia S. Seitz, Christian Rose, Andreas Kerstan, Axel Trautmann Tags: Original Articles Source Type: research

A case of local delayed-type allergy to zinc-containing insulin as a cause of diabetic ketoacidosis in a patient with type 1 diabetes mellitus undergoing continuous subcutaneous insulin infusion
Abstract We herein report a case involving a woman with type 1 diabetes and a history of metal allergy who developed a local delayed-type (type IV) allergy to zinc-containing insulin. She had been treated by continuous subcutaneous insulin infusion, but her glycemic control was poor, and she developed diabetic ketoacidosis. Her plasma insulin concentration was unexpectedly low during use of insulin lispro, but it was recovered by changing from the zinc-containing insulin lispro to the zinc-free insulin glulisine. Intradermal tests showed no reactions to various insulins except for zinc chloride. A skin biopsy at t...
Source: Diabetology International - March 15, 2016 Category: Endocrinology Source Type: research

Mast cell diseases in patients with insect venom allergy: implications for diagnosis and therapy
ConclusionThe determination of baseline serum tryptase (bST) and an examination of the skin are recommended in all adult patients with a  previous history of systemic sting reactions. Patients with mastocytosis of the skin and/or bST elevated above 20 µg/l should always undergo further investigation. If bST is elevated in the absence of mastocytosis, or if a more accurate diagnosis of the mast cell disease is relevant, a so-cal led liquid biopsy can be performed, enabling a KIT mutation (tyrosine kinase receptor) to be investigated in peripheral blood. Bone marrow biopsy, bone density measurement, and upper abdomina...
Source: Allergo Journal International - May 4, 2017 Category: Allergy & Immunology Source Type: research

Drug Allergy.
Abstract Drug allergy is commonly encountered in clinical practice. It is an immunological response to a pharmaceutical agent. The clinical presentation can vary from mild cutaneous reactions to life-threatening conditions such as Stevens-Johnson syndrome and toxic epidermal necrolysis. Diagnosis is most often clinical, but investigations such as measurement of immunoglobulin E, patch testing, and skin biopsy may be required. In patients with a known drug allergy, the offending drug should be avoided. [Pediatr Ann. 2018;47(10):e419-e425.]. PMID: 30308679 [PubMed - in process]
Source: Pediatric Annals - October 1, 2018 Category: Pediatrics Authors: Seth D, Kamat D Tags: Pediatr Ann Source Type: research

Investigation of Patient-Specific Characteristics Associated with Treatment Outcomes for Chronic Urticaria
Conclusions Patient-specific CU characteristics associated with medication-disease control may be useful for selecting treatment regimens. A subset of CU patients remains poorly controlled that indicates an unmet need for novel therapeutic agents.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 13, 2015 Category: Allergy & Immunology Source Type: research

Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis
Conclusions Patients with SM with anaphylaxis display unique clinical and laboratory features. Hence, a risk analysis tool that is capable of discriminating patients with SM at high risk of anaphylaxis from those at low risk with 86% sensitivity was developed by using the variables male sex, absence of mastocytosis in the skin, presence of atopy, IgE levels of 15 kU/L or more, and baseline tryptase levels of less than 40 ng/mL.
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 26, 2017 Category: Allergy & Immunology Source Type: research