Familial clustering of hypereosinophilic diseases treated with mepolizumab: a case report from Japan.

We describe a female diagnosed with non-allergic asthma. On March 24, 2016, examination of the skin-biopsy specimen revealed dense eosinophilic infiltration, and the Fip-1-like 1-platelet-derived growth factor receptor a fusion gene in peripheral blood mononuclear cells was negative. She was diagnosed with idiopathic hypereosinophilic syndrome. She was treated with intravenous methylprednisolone (MPSL), and subsequent oral MPSL. Then, she started to receive a monthly mepolizumab in June 2016, and successfully withdrew from daily use of oral MPSL. The patient has a mother diagnosed with non-allergic asthma. In February 2005, she was diagnosed with eosinophilic granulomatosis with polyangitis because of elevated antineutrophil myeloperoxidase antibodies, and the skin-biopsy specimen findings. She started to receive a monthly mepolizumab in June 2016. Corticosteroid therapy was successfully withdrawn. To our knowledge, this is the first case report suggesting mepolizumab may be a useful treatment for familial clustering of hypereosinophilic diseases. PMID: 31594295 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Related Links:

The objective of this study was to test the hypothesis that comorbid type 2 immune diseases confer protection against morbidity and mortality due to acute infection. Design: Retrospective cohort study of patients hospitalized with an acute infection between November 2008 and January 2016 using electronic health record data. Setting: Single tertiary-care academic medical center. Patients: Admissions to the hospital through the emergency department with likely infection at the time of admission who may or may not have had a type 2 immune-mediated disease, defined as asthma, allergic rhinitis, atopic dermatitis, or f...
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Clinical Investigations Source Type: research
Source: Pulmonary Medicine News - Doctors Lounge - Category: Respiratory Medicine Tags: Dermatology, Family Medicine, Internal Medicine, Allergy, Emergency Medicine, Pathology, Pediatrics, Pharmacy, Pulmonology, Conference, Source Type: news
AbstractPurpose of this reviewTo highlight the evidence behind the various biologics that are being developed for asthma along with their specific targets in the inflammatory cascade and the potential role they serve in the management of allergic asthma.Recent findingsThe mainstay of asthma management for the majority of asthmatics is inhaled corticosteroids with or without long-acting beta-agonists and/or leukotriene modifiers and/or tiotropium. However, in the small group of individuals with severe asthma uncontrolled with conventional therapy, biologics have emerged as an effective therapeutic option.SummaryAsthma is a ...
Source: Current Treatment Options in Allergy - Category: Allergy & Immunology Source Type: research
The 2019 Annual Meeting of the American College of Allergy, Asthma&Immunology The annual meeting of the American College of Allergy, Asthma&Immunology was held from Nov. 7 to 11 in Houston and attracted approximately 3,500 participants...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Source: eMedicineHealth.com - Category: General Medicine Source Type: news
Our data illustrate that modulation of autophagy can critically affect ILC2 effector functions through metabolic reprogramming, opening avenues for novel treatment of ILC2-associated airway inflammation and asthma.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Vaginal delivery and breastfeeding lessen the number of new allergy and asthma cases in children up to the age of 18 years, according to new research.
Source: WebMD Health - Category: Consumer Health News Source Type: news
This study aimed to delineate the causal relation between GERD and asthma.MethodsParticipants of the Korean National Health Insurance Service-National Sample Cohort 2002-2013 who were ≥ 20 years old were selected for this study. In study I, 116,502 GERD patients were matched in a 1:2 ratio to 233,004 control I participants, and the hazard ratio (HR) of asthma in GERD patients was analyzed. In study II, 104,146 asthma patients were matched in a 1:1 ratio to 104,146 control II participants, and the HR for GERD in asthma patients was analyzed. A stratified Cox-proportional hazards model was used. Subgroup analyses were per...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
This study suggests that a simple risk-assessment tool could potentially be created for emergency rooms in similar settings to identify higher-risk children on whom limited resources might be better focused.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma Source Type: research
Conclusions The long-term risks of autoimmune disorders are significantly higher in patients with allergic diseases. Allergic diseases and autoimmune disorders show age- and sex-related clustering patterns.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Original Articles: Asthma and allergy Source Type: research
More News: Allergy | Allergy & Immunology | Asthma | Corticosteroid Therapy | Genetics | Japan Health | Methylprednisolone | Skin | Skin Biopsy