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Total 92 results found since Jan 2013.
Crohn & #39;s Disease Presenting as Metabolic Myopathy: A Case Report
We report a 20-yearr-old lady who presented with a painful proximal myopathy. On examination, she was malnourished with pallor, angular cheilitis, Bitots spots, and bilateral pitting pedal edema. Laboratory evaluation showed iron deficiency anemia, hypoalbuminemia, and very low vitamin D levels with elevated creatine phosphokinase levels. A possibility of osteomalacic metabolic myopathy due to vitamin D deficiency was considered. The malabsorption workup was negative. A colonoscopic biopsy showed noncaseating granulomatous inflammation suggestive of Crohn's disease. With supplementary therapy and specific treatm...
Source: Neurology India - July 1, 2022 Category: Neurology Authors: Sabu Kunnathuparambil George Neena Baby Prasanth Varghese Thalakottur Kuriakose Joseph Source Type: research
Vitamin D deficiency: A forgotten treatable cause of motor delay and proximal myopathy
We report a four-year-old African boy referred for proximal muscle weakness, fatigability and episodic limb pain. Classical causes of structural and metabolic myopathy were initially considered before clinical and biological features of vitamin D deficiency rickets were identified. Prompt treatment with vitamin D and calcium supplementation led to a complete reversal of the muscle symptoms. Rickets-associated myopathy should be included in the differential diagnosis of proximal myopathy, especially in at-risk individuals. Vitamin D deficiency and its prevention remain important health issues in industrialized countries.
Source: Brain and Development - December 28, 2012 Category: Neurology Authors: Joel Fluss, Ilse Kern, Geraldo de Coulon, Elsa Gonzalez, Hassib Chehade Tags: Case reports Source Type: research
Effective treatment of mitochondrial myopathy by nicotinamide riboside, a vitamin B3
Abstract
Nutrient availability is the major regulator of life and reproduction, and a complex cellular signaling network has evolved to adapt organisms to fasting. These sensor pathways monitor cellular energy metabolism, especially mitochondrial ATP production and NAD+/NADH ratio, as major signals for nutritional state. We hypothesized that these signals would be modified by mitochondrial respiratory chain disease, because of inefficient NADH utilization and ATP production. Oral administration of nicotinamide riboside (NR), a vitamin B3 and NAD+ precursor, was previously shown to boost NAD+ levels in mice and to induce mi...
Source: EMBO Molecular Medicine - April 1, 2014 Category: Molecular Biology Authors: Nahid A Khan, Mari Auranen, Ilse Paetau, Eija Pirinen, Liliya Euro, Saara Forsström, Lotta Pasila, Vidya Velagapudi, Christopher J Carroll, Johan Auwerx, Anu Suomalainen Tags: Research Article Source Type: research
Equine atypical myopathy: a metabolic study
Publication date: Available online 29 July 2016 Source:The Veterinary Journal Author(s): R. Karlíková, J. Široká, P. Jahn, D. Friedecký, A. Gardlo, H. Janečková, F. Hrdinová, Z. Drábková, T. Adam Atypical myopathy is a potentially fatal disease of grazing horses. It is reportedly caused by the ingestion of sycamore seeds containing toxic hypoglycin A. In order to study metabolic changes, serum and urine samples from nine horses with atypical myopathy and 12 control samples from clinically healthy horses were collected and then analysed using a high-performance liquid chromatography coupled with tandem ...
Source: The Veterinary Journal - July 29, 2016 Category: Veterinary Research Source Type: research
Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy.
CONCLUSION: Almost all subjects showed Vitamin D deficiency. No difference was detected between those with and without CIPNM. The condition might represent a secondary phenomenon resulting from the inflammatory process as well as from conditions that could interfere with vitamin D metabolism.
PMID: 32131367 [PubMed - in process]
Source: Journal of Musculoskeletal Neuronal Interactions - March 6, 2020 Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research
Vitamin d receptor gene polymorphisms and haplotypes in hungarian patients with idiopathic inflammatory myopathy.
Abstract
Idiopathic inflammatory myopathies are autoimmune diseases characterized by symmetrical proximal muscle weakness. Our aim was to identify a correlation between VDR polymorphisms or haplotypes and myositis. We studied VDR-BsmI, VDR-ApaI, VDR-TaqI, and VDR-FokI polymorphisms and haplotypes in 89 Hungarian poly-/dermatomyositis patients (69 females) and 93 controls (52 females). We did not obtain any significant differences for VDR-FokI, BsmI, ApaI, and TaqI genotypes and allele frequencies between patients with myositis and healthy individuals. There was no association of VDR polymorphisms with clinical man...
Source: Biomed Res - February 7, 2015 Category: Research Authors: Bodoki L, Chen JQ, Zeher M, Nagy-Vincze M, Griger Z, Zilahi E, Dankó K Tags: Biomed Res Int Source Type: research
Hypermethylation: Causes and Consequences in Skeletal Muscle Myopathy
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 15, 2016 Category: Biochemistry Authors: Avisek Majumder, JyotirmayaBehera, Navena Jeremic, Suresh C Tyagi Tags: Article Source Type: research
Common therapeutic approaches of sarcopenia in the elderly and uremic myopathy.
Abstract
The gradual loss of weight and function of muscle in patients with chronic kidney disease as in the elderly impacts the quality of life. Early management should help slow the functional limitation. Physical activity is the first therapy to propose that ensures stability of muscle mass and improved function. Resistance training programs have proven effective but are not yet widely available in nephrology units. The nutritional management should not be forgotten because there is a resistance to anabolism and protein intake should be involved in physical activity program. Associated treatments should not be ...
Source: Nephrologie and Therapeutique - June 9, 2017 Category: Urology & Nephrology Authors: Chauveau P, Moreau K, Lasseur C, Combe C, Aparicio M Tags: Nephrol Ther Source Type: research
Myopathy: Effect of Vitamin D Deficiency Beyond Bones.
We report the case of a middle aged female with chronic quadriparesis and new onset anemia associated with Vitamin D deficiency. Patient responded to vitamin D supplementation alone.
PMID: 29319256 [PubMed - in process]
Source: Journal of the Association of Physicians of India - January 11, 2018 Category: General Medicine Tags: J Assoc Physicians India Source Type: research
GSE129811 The effect of an NAD+ precursor vitamin B3, niacin, on muscle transcriptomic profiles of mitochondrial myopathy patients and healthy controls
Conclusions: These results showed that niacin modulated the expression of disease associated pathways and suppressed mTOR signalling in patients but niacin did not affect disease-related ISRmt signalling.
Source: GEO: Gene Expression Omnibus - September 17, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
An overview of statin-induced myopathy and perspectives for the future.
Authors: Nikolic D, Banach M, Chianetta R, Luzzu LM, Pantea Stoian A, Diaconu CC, Citarrella R, Montalto G, Rizzo M
Abstract
Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin to...
Source: Expert Opinion on Drug Safety - April 3, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Bariatric surgery related proximal myopathy: A partially reversible complication
We report cases of five patients with morbid obesity who developed within 2 to 4 months of a BS, proximal myopathy following significant and rapid weight loss worsened by postoperative gastrointestinal complications. Muscle weakness concerned lower limbs in particular in quadriceps and less frequently in upper limbs and diaphragm, sometimes mimicked a Guillain-Barré syndrome. Muscle biopsy performed in 1 patient, revealed selective atrophy of type 2 fibers. Weakness slowly decreased with refeeding with vitamins supplementation. We enlarge here the clinical pattern of post-BS complications.PMID:33640114 | DOI:10.1016/j.neurol.2020.10.012
Source: Revue Neurologique - February 28, 2021 Category: Neurology Authors: M Brisset M C Durand A Iosif M Hanachi C Palazzo R-Y Carlier P Lafor êt G Nicolas Source Type: research
Epidemiological and genetic features of anti-3 ‑hydroxy-3-methylglutaryl-CoA reductase necrotizing myopathy: Single-center experience and literature review
CONCLUSION: In northern Spain, anti-HMGCR IMNM preferentially affects people over 50 years of age who are carriers of the HLA-DRB1*11 allele and take statins. Both low vitamin D levels and hypothyroidism may play a potential predisposing role in the development of this disease.PMID:35487805 | DOI:10.1016/j.ejim.2022.04.017
Source: European Journal of Internal Medicine - April 29, 2022 Category: Internal Medicine Authors: Diana Prieto-Pe ña Javier G Ocejo-Vinyals Joel Mazariegos-Cano Ana L Pelayo-Negro Sara Remuzgo-Mart ínez Fernanda Genre Alicia Garc ía-Dorta M ónica Renuncio-García V íctor M Martínez-Taboada Carmen Garc ía-Ibarbia Julio S ánchez-Martín Marcos L Source Type: research
