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MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools
Conclusion In conclusion, the results of this study proved that PMEAF is a promising anticancer agent with high cytotoxicity against MDA-MB-231 breast cancer cells and it induced apoptotic cell death mechanism through the regulation of miRNAs. PMEAF might be the best candidate for developing more potent anticancer drugs or chemo preventive supplements. Graphical abstract
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 22, Pages 2170: Natural Korean Medicine Dang-Gui: Biosynthesis, Effective Extraction and Formulations of Major Active Pyranocoumarins, Their Molecular Action Mechanism in Cancer, and Other Biological Activities
Jang Sung Koo Angelica gigas Nakai (AGN) is a crucial oriental medicinal herb that grows especially in Korea and the Far-East countries. It contains chemically active compounds like pyranocoumarins, polyacetylenes and essential oils, which might be useful for treatment of several chronic diseases. It has been used for centuries as a traditional medicine in Southeast Asia, but in Western countries is used as a functional food and a major ingredient of several herbal products. The genus Angelica is also known as ‘female ginseng’ due to its critical therapeutic role in female afflictions, such as gynecological probl...
Source: Molecules - December 7, 2017 Category: Chemistry Authors: Chinreddy Reddy Seong Kim Mok Hur Yeon Kim Chun Park Woo Lee Jae Jang Sung Koo Tags: Review Source Type: research

Proteins isolated of Pueraria Radix possible to cause allergenic react with immunoglobulin E in human sera
ConclusionThe results imply thatPueraria Radix can act as an allergen given the identification of IgE binding proteins among the isolated proteins ofPueraria Radix.
Source: Molecular and Cellular Toxicology - March 24, 2018 Category: Cytology Source Type: research

How Should Fruits and Vegetables Be Washed?
Discussion Fruits and vegetables are great sources of nutrition and often are eaten raw. However, they can become contaminated during harvest, transportation, production, preparation and storage. Produce accounts for about half of all foodborne illness and about 20% of foodborne deaths. Outbreaks have been associated with all food sources including home gardens, local farms and large scale commercial food operations. Vegetables most associated with illness are leafy green vegetables, herbs and sprouts. Learning Point What are the best ways to keep raw fruits and vegetables safe? “Wash your hands with hot soapy water...
Source: PediatricEducation.org - June 4, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

People Are Now Taking Placebo Pills to Deal With Their Health Problems —And It’s Working
For over 20 years, Linda Buonanno lived in fear that her irritable bowel syndrome (IBS) would suddenly interrupt her daily routine with frequent trips to the bathroom and unbearable cramping. Buonanno, now a 71-year-old medical assistant and hairdresser from Methuen, Mass., tried everything from drugs to dairy-free diets. Nothing worked. She remembers a particularly tough period over 10 years ago, when she was working on the factory floor of a medical-device company for up to 10 hours a day, six days a week. When an IBS episode would strike, her co-workers would cover for her as she huddled in a corner, keeled over in pain...
Source: TIME: Health - August 23, 2018 Category: Consumer Health News Authors: Alexandra Sifferlin Tags: Uncategorized medicine Research Source Type: news

Public Library Spotlight: Juanita Harrell, Health & Wellness Librarian, Oak Park Public Library
Name: Juanita Harrell Title: Health & Wellness Librarian Education: MLIS Dominican University How did you become interested in focusing on Health and Wellness? I’ve always been interested in Health & Wellness & was given the opportunity to make it my area of concentration. Why is health literacy important in your community? Making information available and accessible to the general public about health and wellness is beneficial to both the providers of services and the members of the community. What’s different with a health reference interview? In a health reference interview you have to take into co...
Source: The Cornflower - August 28, 2018 Category: Databases & Libraries Authors: Bobbi Newman Tags: Public Libraries Public Libraries Spotlight libs4health oak park public library public libraries and health Source Type: news

Does Echinacea Work? Here ’s What the Science Says
During cold season, people often search for natural cold remedies and immunity boosters. Echinacea has long been rumored to both prevent and knock out colds. But the evidence in favor of the herbal supplement is mixed, and its varied preparations make it hard to study. The name “echinacea” refers to almost 10 species of flowering herb, and echinacea supplements use one or several of these species. They can be made using either the plant’s above-ground parts or its below-ground roots (or both). All this variance has led to disagreement among experts when it comes to echinacea’s benefits. “Our s...
Source: TIME: Health - November 7, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Research Source Type: news

Does Echinacea Really Work Against Colds? Here ’s What the Science Says
During cold season, people often search for natural cold remedies and immunity boosters. Echinacea has long been rumored to both prevent and knock out colds. But the evidence in favor of the herbal supplement is mixed, and its varied preparations make it hard to study. The name “echinacea” refers to almost 10 species of flowering herb, and echinacea supplements use one or several of these species. They can be made using either the plant’s above-ground parts or its below-ground roots (or both). All this variance has led to disagreement among experts when it comes to echinacea’s benefits. “Our s...
Source: TIME: Health - November 7, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Research Source Type: news

Molecules, Vol. 24, Pages 102: Ethnomedicinal, Phytochemical and Pharmacological Investigations of Perilla frutescens (L.) Britt.
d Perilla frutescens (L.) Britt. (PF) is an annual herbal medicinal, aromatic, functional food, and ornamental plant that belongs to the mint family, Lamiaceae. The origin of perilla traces back to East Asian countries (China, Japan, Korea, Taiwan, Vietnam, and India), where it has been used as a valuable source of culinary and traditional medicinal uses. The leaves, seeds, and stems of P. frutescens are used for various therapeutic applications in folk medicine. In the absence of a comprehensive review regarding all aspects of perilla, this review aims to present an overview pertaining to the botanical drug, ethnobota...
Source: Molecules - December 28, 2018 Category: Chemistry Authors: Hiwa M. Ahmed Tags: Review Source Type: research

Next-Generation Approaches for the Treatment of Food Allergy
AbstractPurpose of ReviewIgE-mediated food allergies are an increasing health concern, and current management includes food avoidance and use of emergency medications. Effective treatment of food allergy is highly desirable. Next generation approaches for the treatment of food allergy aim to improve both safety and efficacy, potentially including long-term tolerance.Recent FindingsOral immunotherapy (OIT) and epicutaneous immunotherapy (EPIT) will likely be integrated into clinical practice as part of food allergy management in the near future. Newer approaches, such as sublingual immunotherapy (SLIT), modified proteins, l...
Source: Current Allergy and Asthma Reports - January 28, 2019 Category: Allergy & Immunology Source Type: research

Molecules, Vol. 24, Pages 683: Changes of Phytochemical Components (Urushiols, Polyphenols, Gallotannins) and Antioxidant Capacity during Fomitella fraxinea –Mediated Fermentation of Toxicodendron vernicifluum Bark
This study aimed to investigate the dynamic changes of urushiols, bioactive compounds, and antioxidant properties during the fermentation of TVSB by mushroom F. fraxinea. The contents of urushiols, total polyphenols, and individual flavonoids (fisetin, fustin, sulfuretin, and butein) and 1,2,3,4,6-penta-O-galloyl-β-D-glucose (PGG) significantly decreased during the first 10 days of fermentation, with only a slight decrease thereafter until 22 days. Free radical scavenging activities using 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis(3-ethylbenzothiazoline-6- sulfonic acid) (ABTS), and fer...
Source: Molecules - February 14, 2019 Category: Chemistry Authors: Da-Ham Kim Min-Ji Kim Dae-Woon Kim Gi-Yoon Kim Jong-Kuk Kim Yoseph Asmelash Gebru Han-Seok Choi Young-Hoi Kim Myung-Kon Kim Tags: Article Source Type: research

A guinea pig model of Ciwujia Injection-induced anaphylaxis for allergic substance screening
ConclusionThis guinea pig model may provide a powerful tool to study the mechanism in CWJI induced anaphylaxis and screen the allergic source of CWJI.
Source: Chinese Herbal Medicines - March 10, 2019 Category: Complementary Medicine Source Type: research

Qingpeng Ointment Ameliorates Inflammatory Responses and Dysregulation of Itch-Related Molecules for Its Antipruritic Effects in Experimental Allergic Contact Dermatitis
Conclusion Via a HPLC system and a BATMAN-TCM platform, for the first time we performed detailed HPLC fingerprint analysis and network pharmacology studies of QP ointment. By in-depth animal and molecular analysis, we identified a number of chronic dermatitis-associated Th1/2 cytokines, itch mediators, and cellular signaling pathways in the skin, DRG and serum for QP to treat the inflammation and chronic itch associated with ACD. Our data clearly suggested, upon stimulation, cytokines and itch-related mediators are released from the skin and neuronal tissues, and QP could effectively work on both the skin and sensory neur...
Source: Frontiers in Pharmacology - April 8, 2019 Category: Drugs & Pharmacology Source Type: research