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Better recognition, diagnosis and management of non-IgE-mediated cow ’s milk allergy in infancy: iMAP—an international interpretation of the MAP (Milk Allergy in Primary Care) guideline
Abstract Cow ’s milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood. It is also one of the most complex food allergies, being implicated in IgE-mediated food allergy as well as diverse manifestations of non-IgE-mediated food allergy. For example, gastrointestinal CMA may present as food protein induced enteropathy, enterocolitis or proctocolitis. Concerns regarding the early and timely diagnosis of CMA have been highlighted over the years. In response to these, guideline papers from the United Kingdom (UK), Australia, Europe, the Americas and the World Aller gy Organisation ...
Source: Clinical and Translational Allergy - August 23, 2017 Category: Allergy & Immunology Source Type: research

Lymphoproliferative responses to dendritic cell presentation of sensitizing allergens in atopic children with multiple allergies.
CONCLUSION: The DC-induced lymphoproliferation had higher sensitivity, specificity, and reproducibility than the standard assay and caused increased memory and activated T-cell proliferation in children with food allergy. PMID: 28890022 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - September 1, 2017 Category: Allergy & Immunology Authors: Scott-Taylor TH, Axinia SC, Strobel S Tags: Ann Allergy Asthma Immunol Source Type: research

Prevalence and longitudinal trends of food allergy during childhood and adolescence: results of the Isle of Wight Birth Cohort study
ConclusionFood allergy is highly prevalent in infancy with partial resolution during late childhood. However, a number of children acquire new food allergy during adolescence resulting in a relatively higher prevalence at 18 years.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - January 8, 2018 Category: Allergy & Immunology Authors: D Venkataraman, M Erlewyn ‐Lajeunesse, R J Kurukulaaratchy, S Potter, G Roberts, S Matthews, S Hasan Arshad Tags: Original Article ‐Epidemiology of Allergic Disease Source Type: research

Low Concentration of Fecal Valeric Acid at 1 Year of Age Is Linked with Eczema and Food Allergy at 13 Years of Age: Findings from a Swedish Birth Cohort
Conclusions: Our findings lend further support to the notion of early childhood as a critical period when allergy may be programmed via the gut microbiota. Higher levels of fecal valeric acid may be characteristic of a protective gut microbiota and/or actively contribute to protection from eczema and food allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - November 26, 2021 Category: Allergy & Immunology Source Type: research

Multicolor flow-cytometric analysis of milk allergen-specific T-helper type 2 cells revealed coexpression of interleukin-4 with Foxp3.
CONCLUSION: Increased numbers of IL-4-producing allergen-specific T-helper cells were found in patients with milk allergy. In addition, Foxp3 was coexpressed with IL-4 in allergen-specific TH2 cells from patients. This coexpression was associated with lower Bcl-2 levels and could contribute to the phenotype and function of TH2 cells. PMID: 26507707 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - October 21, 2015 Category: Allergy & Immunology Authors: Yamawaki K, Inuo C, Nomura T, Tanaka K, Nakajima Y, Kondo Y, Yoshikawa T, Urisu A, Tsuge I Tags: Ann Allergy Asthma Immunol Source Type: research

Nutritional Issues in Food Allergy
AbstractDiet and nutrition play an important role in the development and management of food allergy. The diet of expectant mothers can have an effect on their offspring in terms of allergic outcomes. A host of confounding factors may influence this, with a maternal diet rich in fruits and vegetables, fish, vitamin D-rich foods associated with a lower risk of allergic disease in their children. More surprisingly, the consumption of milk and butter has also been shown to have a protective effect, especially in a farm environment. Similarly, the diet of the infant can also be important, not only in terms of breast feeding, bu...
Source: Clinical Reviews in Allergy and Immunology - May 15, 2018 Category: Allergy & Immunology Source Type: research

The Consortium for Food Allergy Research (CoFAR) The First Generation
The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut al...
Source: Journal of Allergy and Clinical Immunology - December 23, 2018 Category: Allergy & Immunology Authors: Hugh A. Sampson, M Cecilia Berin, Marshall Plaut, Scott H. Sicherer, Stacie Jones, A Wesley Burks, Robert Lindblad, Donald YM. Leung, Robert A. Wood Source Type: research

Lip dose challenges in food allergy: Current practice and diagnostic utility in the United Kingdom
ConclusionsThe majority of UK Allergy clinics included LDC as an initial step during OFC, despite a wide variation in how LDC are performed and interpreted, which raises major concerns about the reproducibility and the validity of the test. We found that LDC had poor sensitivity as an alternative or initial step to formal OFC.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 10, 2019 Category: Allergy & Immunology Source Type: research

Predictors of Persistent Milk Allergy in Children: A Retrospective Cohort Study
Conclusions: The history of anaphylaxis and high milk-specific IgE levels were associated with persistent CM allergy.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - January 23, 2018 Category: Allergy & Immunology Source Type: research

The Impact of Baked Egg and Baked Milk Diets on IgE- and Non-IgE-Mediated Allergy
AbstractBaked milk (BM) and baked egg (BE) diets are increasingly used in the management of milk and egg allergy, rather than avoidance. Children with tolerance versus reactivity to BM and BE may have smaller skin prick test and lower specific IgE, and BM-tolerant children have less basophil reactivity and more peripheral T regulatory cells. However, most milk- and egg-allergic children tolerate BM and BE and an individual ’s reactivity is unpredictable. Non-reactivity is due to conformational changes in the allergens. Significant differences in the published advice about methods of introduction exist from graded introdu...
Source: Clinical Reviews in Allergy and Immunology - March 8, 2018 Category: Allergy & Immunology Source Type: research

Oral food challenge failures among foods restricted due to atopic dermatitis.
CONCLUSION: The frequency of OFC failure among those who removed foods suspected as AD triggers was 13.3%, indicating a loss of tolerance. Restriction of foods to manage AD must be done with caution and close monitoring. PMID: 30326323 [PubMed - as supplied by publisher]
Source: Annals of Allergy, Asthma and Immunology - October 13, 2018 Category: Allergy & Immunology Authors: Eapen AA, Kloepfer KM, Leickly FE, Slaven JE, Vitalpur G Tags: Ann Allergy Asthma Immunol Source Type: research

Timing of Introduction, Sensitization and Allergy to Highly-Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort
ConclusionsGeneral-population infants introduced to peanut after age 12 months were more likely to have sensitization and probable clinical allergy to peanut at 3 years.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 31, 2019 Category: Allergy & Immunology Source Type: research

Timing of Introduction, Sensitization, and Allergy to Highly Allergenic Foods at Age 3 Years in a General-Population Canadian Cohort
ConclusionsGeneral-population infants introduced to peanut after age 12 months were more likely to have sensitization and probable clinical allergy to peanut at 3 years.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 16, 2020 Category: Allergy & Immunology Source Type: research

Prevention of food allergy: can we stop the rise of IgE mediated food allergies?
Purpose of review Food allergy has become more prevalent in recent decades. Without a curative treatment for food allergy, prevention is key. Can we intervene and halt the food allergy epidemic? Recent findings There are three main hypotheses to explain the rise in food allergy: the dual-allergen exposure hypothesis, the hygiene hypothesis and the vitamin D hypothesis. In a recent systematic review of randomized controlled trials, only introduction of allergenic foods, namely egg and peanut, in the diet at the time of weaning and avoidance of temporary supplementation with cow's milk formula in the first few day...
Source: Current Opinion in Allergy and Clinical Immunology - March 3, 2021 Category: Allergy & Immunology Tags: GENETICS AND EPIDEMIOLOGY: Edited by Isabella Annesi-Maesano and Antonella Cianferoni Source Type: research

How to diagnose and manage cow ’s milk protein allergy
Dr Toni Hazell offers advice on how to ensure cow’s milk protein allergy is addressed appropriately in primary care Cow’s milk allergy (CMA, also known as cow’s milk protein allergy or CMPA) is defined by NICE as ‘a reproducible immune-mediated allergic response to one or more proteins in cow’s milk’.1 To understand the two different types... Read moreThe post How to diagnose and manage cow’s milk protein allergy appeared first on Nursing in Practice.
Source: Nursing in Practice - April 11, 2023 Category: Nursing Authors: Jon Lalljee Tags: Allergy Baby Care Clinical Paediatrics cow;s milk allergy; food allergy Source Type: news