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One Little Girl Beat The Deadliest Form Of Tuberculosis. She Is Very Lucky.
WASHINGTON ― When Baltimore resident Arjun kisses his 6-year-old daughter’s forehead, it’s not always just a sign of affection.
His daughter, Sujata, is onto him. “Is that a temperature kiss?” she asks.
Arjun compulsively checks his little girl’s temperature for a reason. Sujata is the survivor of the “first well-described case” of extensively drug-resistant tuberculosis in a young child in the U.S., according to her physicians.
Tuberculosis is the world’s biggest killer among infectious diseases, and extensively drug-resistant tuberculosis ― or XDR-TB, which is re...
Source: Healthy Living - The Huffington Post - March 24, 2017 Category: Consumer Health News Source Type: news
Sources of racial disparities in HIV prevalence in men who have sex with men in Atlanta, GA, USA: a modelling study
Publication date: Available online 18 April 2017 Source:The Lancet HIV Author(s): Steven M Goodreau, Eli S Rosenberg, Samuel M Jenness, Nicole Luisi, Sarah E Stansfield, Gregorio A Millett, Patrick S Sullivan Background In the USA, men who have sex men (MSM) are at high risk for HIV, and black MSM have a substantially higher prevalence of infection than white MSM. We created a simulation model to assess the strength of existing hypotheses and data that account for these disparities. Methods We built a dynamic, stochastic, agent-based network model of black and white MSM aged 18–39 years in Atlanta, GA, USA, that incorpo...
Source: The Lancet HIV - April 19, 2017 Category: Infectious Diseases Source Type: research
The World Is Not Ready for the Next Pandemic
Across China, the virus that could spark the next pandemic is already circulating. It’s a bird flu called H7N9, and true to its name, it mostly infects poultry. Lately, however, it’s started jumping from chickens to humans more readily–bad news, because the virus is a killer. During a recent spike, 88% of people infected got pneumonia, three-quarters ended up in intensive care with severe respiratory problems, and 41% died.
What H7N9 can’t do–yet–is spread easily from person to person, but experts know that could change. The longer the virus spends in humans, the better the chance that i...
Source: TIME.com: Top Science and Health Stories - May 4, 2017 Category: Consumer Health News Authors: Bryan Walsh Tags: Uncategorized CDC Disease ebola Gates Foundation MERS outbreak pandemic Zika Source Type: news
Doxycycline for outpatient-treated acute exacerbations of COPD: a randomised double-blind placebo-controlled trial
Publication date: Available online 5 May 2017 Source:The Lancet Respiratory Medicine Author(s): Patricia van Velzen, Gerben ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins Background Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unkn...
Source: The Lancet Respiratory Medicine - May 6, 2017 Category: Respiratory Medicine Source Type: research
Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study
This study is registered with ClinicalTrials.gov, number NCT01052480. Findings Between Jan 13, 2011, and March 2, 2015, 113 participants were screened for eligibility and 98 were randomly assigned from 20 out of 29 participating sites. Of the participants with confirmed influenza (by PCR), 28 (67%) of 42 in the plasma plus standard care group normalised their respiratory status by day 28 compared with 24 (53%) of 45 participants on standard care alone (p=0·069). The hazard ratio (HR) comparing plasma plus standard care with standard care alone was 1·71 (95% CI 0·96–3·06). Six participants died, one (2%) from the plas...
Source: The Lancet Respiratory Medicine - May 16, 2017 Category: Respiratory Medicine Source Type: research
ERC Starting Grant for allergy research in the gut
(Helmholtz Zentrum M ü nchen - German Research Center for Environmental Health) The European Research Council (ERC) will be funding the ALLERGUT project at the Helmholtz Zentrum M ü nchen for the next five years with an ERC Starting Grant. Working in this framework, the researchers headed by Dr. Caspar Ohnmacht want to discover if and how bacteria in the intestines can assist or prevent the development of allergies. The total funding amounts to 1.5 million euros.
Source: EurekAlert! - Biology - June 2, 2017 Category: Biology Source Type: news
Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis
Publication date: Available online 13 June 2017 Source:The Lancet Haematology Author(s): Mary Eapen, Tao Wang, Paul A Veys, Jaap J Boelens, Andrew St Martin, Stephen Spellman, Carmem Sales Bonfim, Colleen Brady, Andrew J Cant, Jean-Hugues Dalle, Stella M Davies, John Freeman, Katherine C Hsu, Katharina Fleischhauer, Chantal Kenzey, Joanne Kurtzberg, Gerard Michel, Paul J Orchard, Annalisa Paviglianiti, Vanderson Rocha, Michael R Veneris, Fernanda Volt, Robert Wynn, Stephanie J Lee, Mary M Horowitz, Eliane Gluckman, Annalisa Ruggeri Background The standard for selecting unrelated umbilical cord blood units for transplantat...
Source: The Lancet Haematology - June 14, 2017 Category: Hematology Source Type: research
Efficacy of oral pre-exposure prophylaxis (PrEP) for HIV among women with abnormal vaginal microbiota: a post-hoc analysis of the randomised, placebo-controlled Partners PrEP Study
Publication date: Available online 18 July 2017 Source:The Lancet HIV Author(s): Renee Heffron, R Scott McClelland, Jennifer E Balkus, Connie Celum, Craig R Cohen, Nelly Mugo, Elizabeth Bukusi, Deborah Donnell, Jairam Lingappa, James Kiarie, Tina Fiedler, Matthew Munch, David N Fredricks, Jared M Baeten Background Daily oral tenofovir-based pre-exposure prophylaxis (PrEP) is high efficacious for HIV prevention among women with high adherence. However, the effect of abnormal vaginal microbiota on PrEP efficacy is of concern. We investigated whether bacterial vaginosis modified the efficacy of oral PrEP. Methods We used pro...
Source: The Lancet HIV - July 19, 2017 Category: Infectious Diseases Source Type: research
Chikungunya Vaccine Trials Begin
A phase 1 and 2 clinical trial of anexperimental vaccineagainst the viral disease chikungunya has begun enrolling a planned 180 healthy adult volunteers aged 18 to 45 years with funding by the National Institute of Allergy and Infectious Diseases (NIAID). The vaccine, known as MV-CHIKV, is a recombinant live-attenuated measles vaccine virus expressing chikungunya proteins that induce antibody production.
Source: JAMA - July 25, 2017 Category: General Medicine Source Type: research
Aradigm lands NIH grant for inhaled, liposomal products
Aradigm Corp. (NSDQ:ARDM) said today that the National Institute of Allergy and Infectious Diseases and the NIH awarded the company a grant to study the treatment of pulmonary non-tuberculous mycobacteria infections with Aradigm’s inhaled liposomal ciprofloxacin products, Linhaliq and Lipoquin.
The two-year grant is worth approximately $972,000, according to the Hayward, Calif.-based company.
Get the full story at our sister site, Drug Delivery Business News.
The post Aradigm lands NIH grant for inhaled, liposomal products appeared first on MassDevice.
Source: Mass Device - August 15, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Funding Roundup Pharmaceuticals Respiratory Wall Street Beat Aradigm Corp. Source Type: news
The Role and Treatment Implications of Peripheral and Central Processing of Pain, Pruritus, and Nausea in Heightened Somatic Awareness: A Review
This article reviews the acute neural transmission of pain, pruritus, and nausea symptoms, which can begin in the periphery and/or viscera. The subsequent multiple pathways in the central nervous system that become involved in the processing of these symptoms are also discussed. The authors describe human brain imaging studies that have revealed consistent cortical and subcortical networks activated by these symptoms, including sensory, limbic, and associative regions. In particular, the authors discuss information revealed by the studies regarding the primary somatosensory cortex, secondary somatosensory cortex, anterio...
Source: Innovations in Clinical Neuroscience - June 1, 2017 Category: Neuroscience Authors: ICNS Online Editor Tags: Current Issue Neurologic Systems and Symptoms Neurology Pain Review central processing nausea pruritus Source Type: research
Erratum to: Allergen immunotherapy for allergic asthma: protocol for a systematic review
Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:FundingEAACI and the BM4SIT project (Grant Number 601763) in the European Union ’s Seventh Framework Programme FP7.
Source: Clinical and Translational Allergy - September 15, 2017 Category: Allergy & Immunology Source Type: research
Erratum to: Allergen immunotherapy for allergic rhinoconjunctivitis: protocol for a systematic review
Unfortunately this article [1] was published with an error in the Funding section. The BM4SIT project is not acknowledged. This section should be corrected to the below:FundingEAACI and the BM4SIT project (Grant Number 601763) in the European Union ’s Seventh Framework Programme FP7.
Source: Clinical and Translational Allergy - September 15, 2017 Category: Allergy & Immunology Source Type: research
Differences in health-related quality of life between HIV-positive and HIV-negative people in Zambia and South Africa: a cross-sectional baseline survey of the HPTN 071 (PopART) trial
Publication date: Available online 27 September 2017 Source:The Lancet Global Health Author(s): Ranjeeta Thomas, Ronelle Burger, Abigail Harper, Sarah Kanema, Lawrence Mwenge, Nosivuyile Vanqa, Nomtha Bell-Mandla, Peter C Smith, Sian Floyd, Peter Bock, Helen Ayles, Nulda Beyers, Deborah Donnell, Sarah Fidler, Richard Hayes, Katharina Hauck Background The life expectancy of HIV-positive individuals receiving antiretroviral therapy (ART) is approaching that of HIV-negative people. However, little is known about how these populations compare in terms of health-related quality of life (HRQoL). We aimed to compare HRQoL betwee...
Source: The Lancet Global Health - September 28, 2017 Category: International Medicine & Public Health Source Type: research
