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Infectious Disease: Parasitic Diseases

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Total 613 results found since Jan 2013.

Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome
This study was performed to identify alteration of different serum interleukins (ILs) in children with INS, and their predictive value in response to steroid treatment. Three groups of children (27; steroid-sensitive INS, 21; steroid-resistant INS, and 19 healthy controls) with normal serum C3, negative serologic tests of hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV), and parasitic infections were included in this study. Serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-13, and IL-18 were measured, using quantitative colorimetric sandwich ELISA kits. Children with secondary nephro...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Azar Nickavar Ehsan Valavi Baranak Safaeian Parisa Amoori Mostafa Moosavian Source Type: research

An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver
Iran J Allergy Asthma Immunol. 2020 Dec 19;19(6):667-675. doi: 10.18502/ijaai.v19i6.4936.ABSTRACTLoss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) gene causes autosomal dominant hyper immunoglobulin E syndrome (AD-HIES or Job's Syndrome), a rare and complex primary immunodeficiency (PID) syndrome characterized by increased levels of IgE (>2000 IU/mL), eosinophilia, recurrent staphylococcal skin abscesses, eczema, recurrent pneumonia, skeletal and connective tissue abnormalities. Although bacterial and fungal infections are common in AD-HIES, susceptibility to parasitic infect...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Sule Haskologlu Figen Dogu Gulnur Gollu Bahad ır Setenay Akyuzluer Ergin Ciftci Demet Altun Sevgi Keles Meltem Kologlu Aydan Ikinciogullari Source Type: research

Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome
This study was performed to identify alteration of different serum interleukins (ILs) in children with INS, and their predictive value in response to steroid treatment. Three groups of children (27; steroid-sensitive INS, 21; steroid-resistant INS, and 19 healthy controls) with normal serum C3, negative serologic tests of hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV), and parasitic infections were included in this study. Serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-13, and IL-18 were measured, using quantitative colorimetric sandwich ELISA kits. Children with secondary nephro...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Azar Nickavar Ehsan Valavi Baranak Safaeian Parisa Amoori Mostafa Moosavian Source Type: research

α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG4
IgE to α-Gal is a cause of mammalian meat allergy and has been linked to tick bites in North America, Australia, and Eurasia. Reports from the developing world indicate that α-Gal sensitization is prevalent but has been little investigated.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jeffrey M. Wilson, Behnam Keshavarz, Hayley R. James, Maya K.C. Retterer, Alexander J. Schuyler, Alice Knoedler, Lisa J. Workman, Lucy Ng ’ang’a, Martha E. Chico, Eva Rönmark, Peter W. Heymann, Matthew S. Perzanowski, Thomas A.E. Platts-Mills, Philip Source Type: research

An Unexpected Infection in Loss-of-Function Mutations in STAT3: Malignant Alveolar Echinococcosis in Liver
Iran J Allergy Asthma Immunol. 2020 Dec 19;19(6):667-675. doi: 10.18502/ijaai.v19i6.4936.ABSTRACTLoss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3) gene causes autosomal dominant hyper immunoglobulin E syndrome (AD-HIES or Job's Syndrome), a rare and complex primary immunodeficiency (PID) syndrome characterized by increased levels of IgE (>2000 IU/mL), eosinophilia, recurrent staphylococcal skin abscesses, eczema, recurrent pneumonia, skeletal and connective tissue abnormalities. Although bacterial and fungal infections are common in AD-HIES, susceptibility to parasitic infect...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Sule Haskologlu Figen Dogu Gulnur Gollu Bahad ır Setenay Akyuzluer Ergin Ciftci Demet Altun Sevgi Keles Meltem Kologlu Aydan Ikinciogullari Source Type: research

Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome
This study was performed to identify alteration of different serum interleukins (ILs) in children with INS, and their predictive value in response to steroid treatment. Three groups of children (27; steroid-sensitive INS, 21; steroid-resistant INS, and 19 healthy controls) with normal serum C3, negative serologic tests of hepatitis B virus (HBV), hepatitis C virus (HCV), human immune deficiency virus (HIV), and parasitic infections were included in this study. Serum concentrations of IL-1β, IL-2, IL-6, IL-8, IL-13, and IL-18 were measured, using quantitative colorimetric sandwich ELISA kits. Children with secondary nephro...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 19, 2021 Category: Allergy & Immunology Authors: Azar Nickavar Ehsan Valavi Baranak Safaeian Parisa Amoori Mostafa Moosavian Source Type: research

TSLP, IL-33, and IL-25: not just for allergy and helminth infection
The release of cytokines from epithelial and stromal cells is critical for the initiation and maintenance of tissue immunity. Three such cytokines, TSLP, IL-33, and IL-25, are important regulators of type 2 immune responses triggered by parasitic worms and allergens. In particular, these cytokines activate group 2 innate lymphoid cells (ILC2s), Th2 cells, and myeloid cells that drive hallmarks of type 2 immunity. However, emerging data indicates that these tissue-associated cytokines are not only involved in canonical type 2 responses, but are also important in the context of viral infections, cancer, and even homeostasis.
Source: Journal of Allergy and Clinical Immunology - July 18, 2022 Category: Allergy & Immunology Authors: Alison G. Stanbery, Shuchi Smita, Jakob von Moltke, Elia D. Tait Wojno, Steven F. Ziegler Source Type: research

Human IgE mAbs identify major antigens of  parasitic worm infection
Much of our understanding of the targets of IgE comes from studies of allergy, though little is known about the natural immunogenic targets seen after parasitic worm infections.
Source: Journal of Allergy and Clinical Immunology - June 24, 2022 Category: Allergy & Immunology Authors: Azadeh Hadadianpour, Jacob Daniel, Jian Zhang, Benjamin W. Spiller, Asta Makaraviciute, Åsa M. DeWitt, Heather S. Walden, Robert G. Hamilton, R. Stokes Peebles, Thomas B. Nutman, Scott A. Smith Source Type: research

Relationship between < b > < i > Blastocystis < /i > < /b > spp. with Accompanying Food Hypersensitivity and Chronic Spontaneous Urticaria
Conclusion: The eradication ofBlastocystis spp. can improve the disease activity in CSU and the presence of FHRs seems to be risky in CSU patients withBlastocystis spp.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - September 15, 2022 Category: Allergy & Immunology Source Type: research

Allergy, Anaphylaxis, and Nonallergic Hypersensitivity: IgE, Mast Cells, and Beyond
IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in immune defense against parasites, venoms, toxins, etc. However, they are best known for their role in allergies, currently affecting almost one third of the population worldwide. IgE-mediated allergic diseases result from a maladaptive type 2 immune response that promotes the synthesis of IgE antibodies directed at a special class of antigens called allergens. IgE antibodies bind to type I high-affinity IgE receptors (Fc εRI) on mast cells and basophils, sensitizing them to get triggered in a subsequent encounter with the cognate all...
Source: Medical Principles and Practice - October 11, 2022 Category: Internal Medicine Source Type: research

Dupilumab induced hypereosinophilic syndrome (hes)
We describe a case of HES manifesting with altered mental status two months after starting therapy with dupilumab.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: A. Abulhamail, T. Kelbel, J. Lin, L. Funderburk Tags: M028 Source Type: research

Unrecognized parasitic infection as a cause of persistent eosinophilia in an inner-city allergy clinic population
Persistent peripheral blood eosinophilia (absolute eosinophil count (AEC)> 500 cells/mL) is frequently a manifestation of a serious medical problem. Nevertheless, previous studies have shown that patients with persistent eosinophilia are often not adequately evaluated for possible underlying causes.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2022 Category: Allergy & Immunology Authors: P. Regula, M. Beronilla, H. Jakubowicz, A. Fizitskaya, D. Ferastraoaru, M. Ramesh, D. Rosenstreich, G. Hudes Tags: Other: Eosinophil Related Conditions/Eosinophilia/Hypereosinophilia Clemens von Pirquet Award – 2 Place Source Type: research

Oh, Lovely: The Tick That Gives People Meat Allergies Is Spreading
By Megan Molteni for WIRED. First comes the unscratchable itching, and the angry blossoming of hives. Then stomach cramping, and — for the unluckiest few — difficulty breathing, passing out, and even death. In the last decade and a half, thousands of previously protein-loving Americans have developed a dangerous allergy to meat. And they all have one thing in common: the lone star tick. Red meat, you might be surprised to know, isn’t totally sugar-free. It contains a few protein-linked saccharides, including one called galactose-alpha-1,3-galactose, or alpha-gal, for short. More and more people are lear...
Source: Healthy Living - The Huffington Post - June 20, 2017 Category: Consumer Health News Source Type: news

BET Bromodomain Inhibitor iBET151 Impedes Human ILC2 Activation and Prevents Experimental Allergic Lung Inflammation
This study was supported by grants from GSK and the UK Medical Research Council (U105178805). Conflict of Interest Statement AM has grant funding from GSK and AstraZeneca/MedImmune. MB, DJ, AP, DT, and AvO are employees of GSK. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Acknowledgments We are grateful to the Ares staff, genotyping facility, and flow cytometry core for their technical assistance. We thank Jen Walker for advice on the manuscript. Supplementary Material The Supplem...
Source: Frontiers in Immunology - April 8, 2019 Category: Allergy & Immunology Source Type: research

Non-classical B Cell Memory of Allergic IgE Responses
Sean P. Saunders1, Erica G. M. Ma1,2, Carlos J. Aranda1 and Maria A. Curotto de Lafaille1,3* 1Division of Pulmonary, Critical Care and Sleep Medicine, Laboratory of Allergy and Inflammation, Department of Medicine, New York University, New York, NY, United States 2Sackler Institute of Graduate Biomedical Sciences, New York University, New York, NY, United States 3Department of Cell Biology, New York University School of Medicine, New York, NY, United States The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma ce...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research