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Total 613 results found since Jan 2013.

From the Pages of AllergyWatch
For this edition of From the Pages of AllergyWatch, I've chosen articles from the May-June 2022 AllergyWatch focusing on food allergies, the theme of this month's Annals. The first article, with comments from Dr. Lee, presents data from South Africa that alpha-gal allergy can be associated with parasites. The next article, with comments from Dr. Hernandez-Trujilio, reports improved outcomes in patients with EoE managed in multidisciplinary clinics. The last article, with comments from Dr. Lee, reports the use of an amino acid-based formula including synbiotics on infants with cow's milk allergy.
Source: Annals of Allergy, Asthma and Immunology - July 14, 2022 Category: Allergy & Immunology Authors: Stanley M. Fineman, Gerald B. Lee, Vivian Hernandez-Trujillo Tags: Special Series Source Type: research

Allergy, Anaphylaxis and Non-Allergic Hypersensitivity: IgE, Mast Cells and Beyond
IgE-mediated type I hypersensitivity reactions have many reported beneficial functions in the immune defense against parasites, venoms, toxins etc. However, they are best-known for their role in allergy affecting nowadays almost one third of the population worldwide. IgE-mediated allergic diseases result from a maladaptive type 2 immune response that promotes the synthesis of IgE antibodies directed to a special class of antigens called allergens. IgE antibodies bind to type I high affinity IgE receptors (FcepsilonRI) on mast cells and basophils licensing them to get triggered in a subsequent encounter with the cognate all...
Source: Medical Principles and Practice - October 11, 2022 Category: Internal Medicine Source Type: research

The Relationship of Parasite Allergens to Allergic Diseases
AbstractPurpose of ReviewHelminth infections modify the natural history of allergic diseases, by either decreasing or increasing their symptoms. Several helminth components are involved in the increasing of the allergic response and symptoms, overcoming the concomitant immunosuppression of helminthiases. However, the role of individual IgE-binding molecules in this process remains to be defined.Recent FindingsWe updated the list of helminth allergens and IgE-binding molecules, their effects on asthma presentation, and their impact on allergy diagnosis. Data from genetic and epigenetic studies of ascariasis are analyzed. A ...
Source: Current Allergy and Asthma Reports - June 3, 2023 Category: Allergy & Immunology Source Type: research

Diet of hookworms to tackle a bread allergy
James Logan, a biologist at the School of Hygiene and Tropical Medicine also tried leeches and is thinking about maggot therapy• Read about more scientists who go to extremes lengthsA lot of people don't realise that just one metre below your feet walking along Gower Street or Malet Street in London, you have thousands upon thousands of very hungry, potentially dangerous insects.In the basement we have our insectary colonies where we keep lots of different species of mosquitoes, found in all parts of the world. None of them are infected with malaria, but they are in very high numbers. We also have bed bugs, house dust mi...
Source: Guardian Unlimited Science - December 1, 2013 Category: Science Authors: Josh Davis Tags: Allergies Health Medical research Society Technology Features Animals Insects The Observer Environment Science Wildlife Source Type: news

Early life IgE responses in children living in the tropics: A prospective analysis
ConclusionsIn a socioeconomically deprived community from the tropics, sensitization to HDM allergens was very frequent at early life, especially to B. tropicalis. In contrast to expected according to the hygiene hypothesis, unhygienic/poverty conditions were risk factors for allergen sensitization. High CB total IgE levels were a risk factor for allergen sensitization but protected from recurrent wheezing.
Source: Pediatric Allergy and Immunology - December 2, 2013 Category: Allergy & Immunology Authors: Josefina Zakzuk, Nathalie Acevedo, Liliana Cifuentes, Adriana Bornacelly, Jorge Sánchez, Velky Ahumada, Johannes Ring, Markus Ollert, Luis Caraballo Tags: Original Article Source Type: research

CD11a polymorphisms regulate TH2 cell homing and TH2-related disease
Conclusions: Polymorphisms in CD11a critically influence TH2 cell homing and diverse TH2-dependent immunopathologic states in mice and potentially influence the expression of human allergic disease.
Source: Journal of Allergy and Clinical Immunology - May 31, 2013 Category: Allergy & Immunology Authors: John M. Knight, Seung-Hyo Lee, Luz Roberts, C. Wayne Smith, Scott T. Weiss, Farrah Kheradmand, David B. Corry Tags: Mechanisms of allergy and clinical immunology Source Type: research

Do intestinal parasites enhance food allergy and atopic dermatitis?: A study in Warao Amerindian children
ConclusionGut inflammation caused by G. duodenalis may enhance food allergic reactivity contributing to the manifestation of AD in these children. However, other environmental factors (not considered in this work) as well as an atopic background among the Warao population would also contribute to the presence of AD.
Source: Pediatric Allergy and Immunology - January 13, 2014 Category: Allergy & Immunology Authors: Isabel Hagel, Franca Puccio, Elianska López, Dennis Lugo, Maira Cabrera, María C. Di Prisco Tags: Original Article Source Type: research

New childhood and adult reference intervals for total IgE
In this study, sera were collected from 1376 healthy children (702 males and 674 females) with an age range of older than 6 months to 17 years after parental permission was obtained. Patients were included on the basis of participant medical history obtained from parents, chart review (6 months to 7 years), and physical examination (7-17 years). The adults included 128 subjects (64 men and 64 women) ranging in age from 19 to 69 years. Exclusion criteria included patients taking prescription medications, with significant clinical history of a pathological condition. At the time of sample collection, none of the subjects was...
Source: Journal of Allergy and Clinical Immunology - October 17, 2013 Category: Allergy & Immunology Authors: Thomas B. Martins, Michael E. Bandhauer, Ashley M. Bunker, William L. Roberts, Harry R. Hill Tags: Letters to the Editor Source Type: research

Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties.
Abstract ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine (PC) moieties. Screening of a library of ES-62 PC-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when ...
Source: International Journal for Parasitology - June 11, 2014 Category: Parasitology Authors: Rzepecka J, Coates ML, Saggar M, Al-Riyami L, Coltherd J, Tay HK, Huggan JK, Janicova L, Khalaf AI, Siebeke I, Suckling CJ, Harnett MM, Harnett W Tags: Int J Parasitol Source Type: research

IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.
Abstract IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma. Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. IL-33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress. In this review, we discuss the cel...
Source: Current Opinion in Immunology - September 29, 2014 Category: Allergy & Immunology Authors: Cayrol C, Girard JP Tags: Curr Opin Immunol Source Type: research

Do We Need Worms to Promote Immune Health?
Abstract Many immune-mediated diseases like inflammatory bowel disease, multiple sclerosis, type 1 diabetes, asthma, and food allergy appeared to have increased in frequency in developed countries in the latter part of the twentieth century. Reports from less developed countries suggest that the “epidemic” of immune-mediated diseases now is spreading into these regions as well. The “hygiene hypothesis” was developed to partly explain this phenomenon. It has been proposed that modern-day sanitary living has altered our exposure to organisms that provided protection from these diseases in the past. Alternati...
Source: Clinical Reviews in Allergy and Immunology - October 19, 2014 Category: Allergy & Immunology Source Type: research

Allergy and parasites.
Authors: Bruschi F, Araujo MI, Harnett W, Pinelli E PMID: 23476739 [PubMed]
Source: Journal of Parasitology Research - December 1, 2014 Category: Parasitology Tags: J Parasitol Res Source Type: research

The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity
Conclusions In this tropical population, IgE sensitization to Ascaris and the cross-reactive tropomyosins was frequent and associated with clinical indicators of asthma severity. The significant relationship between sensitization to the nematode-specific marker Asc s 1 and ER attendance supports these findings. Moreover, ascariasis increases the human IgE responses to HDM specific allergens.
Source: World Allergy Organization Journal - March 3, 2015 Category: Allergy & Immunology Source Type: research

Parasites-Allergy paradox: Disease mediators or therapeutic modulators
Publication date: Available online 17 March 2015 Source:Journal of Microscopy and Ultrastructure Author(s): Mohammed A. Afifi , Asif A. Jiman-Fatani , Sherif El Saadany , Mahmoud A. Fouad The noticeable phenomenon of an increased frequency of immune-inflammatory disorders, in the industrialized world, has led to the implication of parasitic infections in the pathophysiology of these diseases. Most of the studies investigated the infection connection to allergy have centered on helminthes. Parasitic helminthes are a group of metazoans that are evolutionary diverse, yet converge to evolve common modes of immunomodulation. ...
Source: Journal of Microscopy and Ultrastructure - March 17, 2015 Category: Laboratory Medicine Source Type: research