Filtered By:
Infectious Disease: Parasitic Diseases

This page shows you your search results in order of relevance. This is page number 16.

Order by Relevance | Date

Total 613 results found since Jan 2013.

AMA1-RON2 Complex-based Vaccine Against Malaria
This technology relates to a malaria vaccine composed of a protein complex of Apical Membrane Antigen (AMA1) and rhoptry neck protein 2 (RON2) with an adjuvant. AMA1 is a crucial component of the Plasmodium invasion machinery and is a leading candidate for antimalarial vaccine development. AMA1-based vaccines have shown ability to block red cell invasion in in vitro assays, but protection has so far not translated to in vivo human infections. NIAID investigators have demonstrated that interaction between AMA1 and RON2 (or peptide thereof) is essential for malaria parasites to successfully enter human red blood cells (RBCs...
Source: NIH OTT Licensing Opportunities - June 18, 2014 Category: Research Authors: admin Source Type: research

Microbiota and probiotics in canine and feline welfare.
Abstract Dogs and cats have been cohabiting with us for thousands of years. They are the major human companions. Today, dogs and cats live in urban areas. Cats and most dogs are on high carbohydrate diets and face similar life-style challenges as the human beings. The health and well-being of companion animals, just as their owners, depends on the gut microbes. Providing a proper care and nutritionally balanced diet to companion animals is recognised as a part of our responsibility to maintain the health and wellbeing of our pet. However, as microbiota differences may facilitate exposure to pathogens and harmful e...
Source: Anaerobe - April 8, 2015 Category: Microbiology Authors: Grześkowiak Ł, Endo A, Beasley S, Salminen S Tags: Anaerobe Source Type: research

Toxoplasma gondii infection modulate systemic allergic immune response in BALB/c mice.
Abstract The increased prevalence of allergies in developed countries has been attributed to a reduced exposure to some microbes. In agreement with epidemiological studies, we previously showed that Toxoplasma gondii infection prevents allergic airway inflammation. The mechanisms would be related to the strong Th1 response induced by the parasite and to regulatory cell induction. Herein we further characterized whether T. gondii allergy modulation extents to a systemic level or if it is limited to the lung. Parasite infection before allergic sensitization resulted in a diminished Th2 cytokine response and, when se...
Source: Experimental Parasitology - April 14, 2015 Category: Parasitology Authors: Fenoy IM, Sanchez VR, Soto AS, Picchio MS, Martin V, Goldman A Tags: Exp Parasitol Source Type: research

Self‐limited coeliac like enteropathy: a series of 18 cases highlighting another coeliac disease mimic
ConclusionsHistopathologists need to be aware that a coeliac disease like enteropathy may occur in the setting of an acute gastrointestinal illness and resolve without sequelae.This article is protected by copyright. All rights reserved.
Source: Histopathology - June 4, 2015 Category: Pathology Authors: Ian S. Brown, Andrew Bettington, Mark Bettington, Christophe Rosty Tags: Original Article Source Type: research

Basophils exhibit antibacterial activity through extracellular trap formation
This article is protected by copyright. All rights reserved.
Source: Allergy - June 4, 2015 Category: Allergy & Immunology Authors: S. Yousefi, M. Morshed, P. Amini, D. Stojkov, D. Simon, S. von Gunten, T. Kaufmann, H.‐U. Simon Tags: Brief Communication Source Type: research

Regulation of IgE Responses by γδ T Cells
Abstract Immunoglobulin E (IgE) antibodies play a crucial role in host defense against parasite infections. However, inappropriate IgE responses are also involved in the pathogenesis of allergic diseases. The generation of IgE antibodies is a tightly controlled process regulated by multiple transcription factors, cytokines, and immune cells including γδ T cells. Accumulating evidence demonstrates that γδ T cells play a critical role in regulating IgE responses; however, both IgE-enhancing and IgE-suppressive effects are suggested for these cells in different experimental systems. In this review, we examine th...
Source: Current Allergy and Asthma Reports - July 1, 2015 Category: Allergy & Immunology Source Type: research

Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up.
CONCLUSION: DL may have a multifactorial origin but the IELs infiltrate and HLA are strong predictive factors for CD development and a clinical diagnosis of GS. PMID: 26140001 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - June 28, 2015 Category: Gastroenterology Authors: Losurdo G, Piscitelli D, Giangaspero A, Principi M, Buffelli F, Giorgio F, Montenegro L, Sorrentino C, Amoruso A, Ierardi E, Di Leo A Tags: World J Gastroenterol Source Type: research

Study of Toxocara seropevalence among patients with allergy and healthy individuals in Bulgaria
This article is protected by copyright. All rights reserved.
Source: Parasite Immunology - July 27, 2015 Category: Parasitology Authors: Eleonora Kaneva, Iskra Rainova, Rumen Harizanov, Georgy Nikolov, Iskren Kaftandjiev, Iva Mineva Tags: original paper Source Type: research

Self‐limited coeliac‐like enteropathy: a series of 18 cases highlighting another coeliac disease mimic
ConclusionsHistopathologists need to be aware that a coeliac disease‐like enteropathy may occur in the setting of an acute gastrointestinal illness and resolve without sequelae.
Source: Histopathology - July 28, 2015 Category: Pathology Authors: Ian S Brown, Andrew Bettington, Mark Bettington, Christophe Rosty Tags: Original Article Source Type: research

Effects of environment on human cytokine responses during childhood in the tropics: role of urban versus rural residence
Conclusions In our study population, the immune response of children living in an urban environment was associated more frequently with the production of the immune regulatory cytokine, IL-10. Some factors related to poor hygiene and living conditions were associated with elevated IL-10 production within urban and rural populations.
Source: World Allergy Organization Journal - August 6, 2015 Category: Allergy & Immunology Source Type: research

GATA3 haploinsufficiency does not block allergic sensitization or atopic disease
GATA3 is the major transcription factor that drives TH2 differentiation and inhibits T-bet–driven TH1 differentiation from naive CD4+ T cells in response to TH2-skewing conditions.1 GATA3 is also expressed in the developing parathyroid glands, inner ear, and kidneys and is critical to vertebrate embryonic development.2Gata3 homozygous knockout mice (Gata3−/−) have a total block of T-cell differentiation and die in utero,3,4 whereas hemizygous conditional deletion of Gata3 in CD4+ T cells (Gata3fl/+) leads to impaired IL-4 and IgE production, TH1 cytokine production even in TH2-priming conditions, and failure to con...
Source: Journal of Allergy and Clinical Immunology - August 15, 2015 Category: Allergy & Immunology Authors: Monica G. Lawrence, Jennifer W. Leiding, Jonathan J. Lyons, Amy P. Hsu, Celeste C. Nelson, Nina Jones, Alan Fitzgerald, Wade W. Chien, Lisa Workman, Thomas A. Platts-Mills, Carmen Brewer, Rachel I. Gafni, Kelly D. Stone, Joshua D. Milner, Steven M. Hollan Tags: Letter to the Editor Source Type: research

Human B-cell isotype switching origins of IgE
B cells expressing IgE contribute to immunity against parasites and venoms and are the source of antigen specificity in allergic patients, yet the developmental pathways producing these B cells in human subjects remain a subject of debate. Much of our knowledge of IgE lineage development derives from model studies in mice rather than from human subjects.
Source: Journal of Allergy and Clinical Immunology - August 23, 2015 Category: Allergy & Immunology Authors: Timothy J. Looney, Ji-Yeun Lee, Krishna M. Roskin, Ramona A. Hoh, Jasmine King, Jacob Glanville, Yi Liu, Tho D. Pham, Cornelia L. Dekker, Mark M. Davis, Scott D. Boyd Source Type: research

Diagnostic Assays and Methods of Use for Detection of Filarial Infection
The effort targeting the mosquito borne neglected tropical disease lymphatic filariasis for elimination through mass drug administration by 2020 will require accurate, cost effective methods for detecting early infections. The World Health Organization-recommended immunochromatographic test detects adult Wuchereria bancrofti (Wb) antigen in blood, but shows variable efficacy due to the complex life cycle of the parasites and cross reactivity with other organisms. This variability may hinder effective lymphatic filariasis elimination efforts. This new technology improves available detection methods through use of an isolate...
Source: NIH OTT Licensing Opportunities - September 29, 2011 Category: Research Authors: admin Source Type: research

Vaccines Comprising Sand Fly Salivary Proteins for Control of Leishmania Infection
This invention relates to the use of several peptides from the salivary glands of various sand fly species for the control of leishmania infection. Many of these peptides were shown to be effective in eliciting potent immune responses in animal models and are excellent candidates for the development of vaccines against the disease. A vaccine comprising one of the peptides was used to protect mice challenged with parasites and salivary gland homogenates. A DNA vaccine containing the cDNA for this same peptide also provided protection that lasted at least 3 months after immunization and produced both intense humoral and dela...
Source: NIH OTT Licensing Opportunities - November 1, 2003 Category: Research Authors: admin Source Type: research

The Eosinophil in Health and Disease: from Bench to Bedside and Back
We describe recent advances in the development of epigenetics of eosinophil-related diseases, especially in asthma. Likewise, recent studies have provided us with a more complete appreciation of how eosinophils contribute to the pathogenesis of various diseases, including hypereosinophilic syndrome (HES). Over the past decades, the definition and criteria of HES have been evolving with the progress of our understanding of the disease and some aspects of this disease still remain controversial. We also review recent updates on the genetic and molecular mechanisms of HES, which have spurred dramatic developments in the clini...
Source: Clinical Reviews in Allergy and Immunology - September 26, 2015 Category: Allergy & Immunology Source Type: research